Shaggy-related protein kinase zeta - Arabidopsis thaliana (Mouse-ear cress)

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Reviewed, UniProtKB/Swiss-Prot Q39010 (KSG6_ARATH)

Last modified June 16, 2009. Version 85. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Shaggy-related protein kinase zeta
    EC=2.7.11.1
Alternative name(s):
    ASK-zeta

Gene names

Name:	ASK6
Ordered Locus Names:	At2g30980
ORF Names:	F7F1.19

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May mediate extracellular signals to regulate transcription in differentiating cells By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with beet curly top virus AL4/C4 and tomato golden mosaic virus AL4/AC4.
Post-translational modification	Autophosphorylated mainly on threonine and serine residues By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. Contains 1 protein kinase domain.

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Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	brassinosteroid mediated signaling Inferred from physical interaction. Source: TAIR protein amino acid phosphorylation Inferred from direct assay. Source: TAIR regulation of protein localization Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q2V412	1	EBI-1238323,EBI-1238781
CALM	P62157	1	EBI-1238323,EBI-397403	From a different organism.
CAM1	P25854	1	EBI-1238323,EBI-1235664
CAM6	Q03509	1	EBI-1238323,EBI-1236097
CAM7	P59220	1	EBI-1238323,EBI-1236031
CML10	P30187	1	EBI-1238323,EBI-1238722
CML8	O23320	1	EBI-1238323,EBI-1237764
CML9	Q9S744	1	EBI-1238323,EBI-1236048

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 412

412

Shaggy-related protein kinase zeta

PRO_0000086221

Regions

Domain

72 – 356

285

Protein kinase

Nucleotide binding

78 – 86

ATP By similarity

Sites

Active site

197

Proton acceptor By similarity

Binding site

101

ATP By similarity

Amino acid modifications

Modified residue

Phosphoserine Potential

Modified residue

127

Phosphoserine Potential

Modified residue

136

Phosphothreonine Potential

Modified residue

137

Phosphothreonine Potential

Modified residue

219

Phosphoserine Potential

Modified residue

252

Phosphoserine Potential

Modified residue

293

Phosphothreonine Potential

Modified residue

342

Phosphoserine Potential

Modified residue

346

Phosphothreonine Potential

Experimental info

Sequence conflict

198

V → I in CAA64408. Ref.1

Sequence conflict

198

V → I in CAA70483. Ref.2

Sequence conflict

208

L → H in CAA64408. Ref.1

Sequence conflict

208

L → H in CAA70483. Ref.2

Sequence conflict

228

A → P in CAA64408. Ref.1

Sequence conflict

228

A → P in CAA70483. Ref.2

Sequence conflict

240

A → S in AAM65084. Ref.5

Sequence conflict

281

Q → R in AAM65084. Ref.5

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Sequences

Sequence

Length

Mass (Da)

Tools

Q39010-1 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 2D59622EF1501B8F
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FASTA

412

46,455

        10         20         30         40         50         60 
MTSIPLGPPQ PPSLAPQPPH LHGGDSLKRR PDIDNDKEMS AAVIEGNDAV TGHIISTTIG 

        70         80         90        100        110        120 
GKNGEPKQTI SYMAERVVGT GSFGIVFQAK CLETGESVAI KKVLQDRRYK NRELQLMRLM 

       130        140        150        160        170        180 
DHPNVVSLKH CFFSTTTRDE LFLNLVMEYV PETLYRVLKH YTSSNQRMPI FYVKLYTYQI 

       190        200        210        220        230        240 
FRGLAYIHTA PGVCHRDVKP QNLLVDPLTH QCKLCDFGSA KVLVKGEANI SYICSRYYRA 

       250        260        270        280        290        300 
PELIFGATEY TSSIDIWSAG CVLAELLLGQ PLFPGENSVD QLVEIIKVLG TPTREEIRCM 

       310        320        330        340        350        360 
NPNYTDFRFP QIKAHPWHKV FHKRMPPEAI DLASRLLQYS PSLRCTALEA CAHPFFNELR 

       370        380        390        400        410 
EPNARLPNGR PLPPLFNFKQ ELSGASPELI NRLIPEHVRR QMNGGFPFQA GP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three new cDNAs related to SGG/GSK-3 (SHAGGY/glycogen synthase kinase-3) from Arabidopsis thaliana." Dornelas M.C., Schwebel-Dugue N., Thomas M., Lecharny A., Kreis M. Plant Gene Register PGR97-008 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. Tissue: Leaf.
[2]	"The Arabidopsis SHAGGY-related protein kinase (ASK) gene family: structure, organization and evolution." Dornelas M.C., Lejeune B., Dron M., Kreis M. Gene 212:249-257(1998) [PubMed: 9611268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Columbia. Tissue: Leaf.
[3]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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Cross-references

Sequence databases
	X94938 mRNA. Translation: CAA64408.1. Y09300 Genomic DNA. Translation: CAA70483.1. AC004669 Genomic DNA. Translation: AAC20732.1. AY064020 mRNA. Translation: AAL36376.1. AY094423 mRNA. Translation: AAM19796.1. AY096698 mRNA. Translation: AAM20332.1. AY087542 mRNA. Translation: AAM65084.1.
IPI	IPI00523554.
PIR	A84715. S71266.
RefSeq	NP_180655.1.
UniGene	At.24781
3D structure databases
HSSP	HSSP built from PDB template 1I09 based on UniProtKB P49841.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q39010. 8 interactions.
Genome annotation databases
GeneID	817649.
GenomeReviews	Gene locus AT2G30980 in contig CT485783_GR.
KEGG	ath:AT2G30980.
NMPDR	fig\|3702.1.peg.10157.
Organism-specific databases
GeneFarm	583. 93.
TAIR	At2g30980.
Phylogenomic databases
OMA	Q39010. ATEYTSS.
Enzyme and pathway databases
BRENDA	2.7.11.1. 302. 2.7.11.26. 302.
Gene expression databases
ArrayExpress	Q39010.
GermOnline	AT2G30980. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

KSG6_ARATH

Accession

Primary (citable) accession number: Q39010
Secondary accession number(s): O80862, Q541C5, Q8LAX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 15, 2007
Last modified:	June 16, 2009
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents