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Protein

Shaggy-related protein kinase zeta

Gene

ASK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate extracellular signals to regulate transcription in differentiating cells.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011ATPPROSITE-ProRule annotation
Active sitei197 – 1971Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 869ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • brassinosteroid mediated signaling pathway Source: TAIR
  • protein phosphorylation Source: TAIR
  • regulation of protein localization Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G30980-MONOMER.
BRENDAi2.7.11.26. 399.
ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Shaggy-related protein kinase zeta (EC:2.7.11.1)
Alternative name(s):
ASK-zeta
Gene namesi
Name:ASK6
Ordered Locus Names:At2g30980
ORF Names:F7F1.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G30980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 412411Shaggy-related protein kinase zetaPRO_0000086221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineSequence analysis
Modified residuei127 – 1271PhosphoserineSequence analysis
Modified residuei136 – 1361PhosphothreonineSequence analysis
Modified residuei137 – 1371PhosphothreonineSequence analysis
Modified residuei219 – 2191PhosphoserineSequence analysis
Modified residuei232 – 2321PhosphotyrosineBy similarity
Modified residuei252 – 2521PhosphoserineSequence analysis
Modified residuei293 – 2931PhosphothreonineSequence analysis
Modified residuei342 – 3421PhosphoserineSequence analysis
Modified residuei346 – 3461PhosphothreonineSequence analysis

Post-translational modificationi

Autophosphorylated mainly on threonine and serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ39010.
PRIDEiQ39010.

PTM databases

iPTMnetiQ39010.

Expressioni

Gene expression databases

GenevisibleiQ39010. AT.

Interactioni

Subunit structurei

Interacts with beet curly top virus AL4/C4 and tomato golden mosaic virus AL4/AC4.

Protein-protein interaction databases

BioGridi2998. 2 interactions.
IntActiQ39010. 8 interactions.
STRINGi3702.AT2G30980.1.

Structurei

3D structure databases

ProteinModelPortaliQ39010.
SMRiQ39010. Positions 28-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 356285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233017.
InParanoidiQ39010.
KOiK00924.
OMAiRRQMNGG.
PhylomeDBiQ39010.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIPLGPPQ PPSLAPQPPH LHGGDSLKRR PDIDNDKEMS AAVIEGNDAV
60 70 80 90 100
TGHIISTTIG GKNGEPKQTI SYMAERVVGT GSFGIVFQAK CLETGESVAI
110 120 130 140 150
KKVLQDRRYK NRELQLMRLM DHPNVVSLKH CFFSTTTRDE LFLNLVMEYV
160 170 180 190 200
PETLYRVLKH YTSSNQRMPI FYVKLYTYQI FRGLAYIHTA PGVCHRDVKP
210 220 230 240 250
QNLLVDPLTH QCKLCDFGSA KVLVKGEANI SYICSRYYRA PELIFGATEY
260 270 280 290 300
TSSIDIWSAG CVLAELLLGQ PLFPGENSVD QLVEIIKVLG TPTREEIRCM
310 320 330 340 350
NPNYTDFRFP QIKAHPWHKV FHKRMPPEAI DLASRLLQYS PSLRCTALEA
360 370 380 390 400
CAHPFFNELR EPNARLPNGR PLPPLFNFKQ ELSGASPELI NRLIPEHVRR
410
QMNGGFPFQA GP
Length:412
Mass (Da):46,455
Last modified:May 15, 2007 - v2
Checksum:i2D59622EF1501B8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981V → I in CAA64408 (Ref. 1) Curated
Sequence conflicti198 – 1981V → I in CAA70483 (PubMed:9611268).Curated
Sequence conflicti208 – 2081L → H in CAA64408 (Ref. 1) Curated
Sequence conflicti208 – 2081L → H in CAA70483 (PubMed:9611268).Curated
Sequence conflicti228 – 2281A → P in CAA64408 (Ref. 1) Curated
Sequence conflicti228 – 2281A → P in CAA70483 (PubMed:9611268).Curated
Sequence conflicti240 – 2401A → S in AAM65084 (Ref. 6) Curated
Sequence conflicti281 – 2811Q → R in AAM65084 (Ref. 6) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94938 mRNA. Translation: CAA64408.1.
Y09300 Genomic DNA. Translation: CAA70483.1.
AC004669 Genomic DNA. Translation: AAC20732.1.
CP002685 Genomic DNA. Translation: AEC08470.1.
AY064020 mRNA. Translation: AAL36376.1.
AY094423 mRNA. Translation: AAM19796.1.
AY096698 mRNA. Translation: AAM20332.1.
AY087542 mRNA. Translation: AAM65084.1.
PIRiA84715.
S71266.
RefSeqiNP_180655.1. NM_128652.3.
UniGeneiAt.24781.

Genome annotation databases

EnsemblPlantsiAT2G30980.1; AT2G30980.1; AT2G30980.
GeneIDi817649.
GrameneiAT2G30980.1; AT2G30980.1; AT2G30980.
KEGGiath:AT2G30980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94938 mRNA. Translation: CAA64408.1.
Y09300 Genomic DNA. Translation: CAA70483.1.
AC004669 Genomic DNA. Translation: AAC20732.1.
CP002685 Genomic DNA. Translation: AEC08470.1.
AY064020 mRNA. Translation: AAL36376.1.
AY094423 mRNA. Translation: AAM19796.1.
AY096698 mRNA. Translation: AAM20332.1.
AY087542 mRNA. Translation: AAM65084.1.
PIRiA84715.
S71266.
RefSeqiNP_180655.1. NM_128652.3.
UniGeneiAt.24781.

3D structure databases

ProteinModelPortaliQ39010.
SMRiQ39010. Positions 28-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2998. 2 interactions.
IntActiQ39010. 8 interactions.
STRINGi3702.AT2G30980.1.

PTM databases

iPTMnetiQ39010.

Proteomic databases

PaxDbiQ39010.
PRIDEiQ39010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G30980.1; AT2G30980.1; AT2G30980.
GeneIDi817649.
GrameneiAT2G30980.1; AT2G30980.1; AT2G30980.
KEGGiath:AT2G30980.

Organism-specific databases

TAIRiAT2G30980.

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233017.
InParanoidiQ39010.
KOiK00924.
OMAiRRQMNGG.
PhylomeDBiQ39010.

Enzyme and pathway databases

BioCyciARA:AT2G30980-MONOMER.
BRENDAi2.7.11.26. 399.
ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiQ39010.

Gene expression databases

GenevisibleiQ39010. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three new cDNAs related to SGG/GSK-3 (SHAGGY/glycogen synthase kinase-3) from Arabidopsis thaliana."
    Dornelas M.C., Schwebel-Dugue N., Thomas M., Lecharny A., Kreis M.
    Plant Gene Register PGR97-008
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
    Tissue: Leaf.
  2. "The Arabidopsis SHAGGY-related protein kinase (ASK) gene family: structure, organization and evolution."
    Dornelas M.C., Lejeune B., Dron M., Kreis M.
    Gene 212:249-257(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
    Tissue: Leaf.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKSG6_ARATH
AccessioniPrimary (citable) accession number: Q39010
Secondary accession number(s): O80862, Q541C5, Q8LAX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.