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Protein

Meiotic recombination protein DMC1 homolog

Gene

DMC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (PubMed:10488231, PubMed:23300481). Mediates interhomolog recombination during meiosis (PubMed:17785529).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei235ssDNA or dsDNABy similarity1
Binding sitei238ssDNABy similarity1
Binding sitei241ssDNA or dsDNABy similarity1
Binding sitei247ssDNA or dsDNABy similarity1
Binding sitei315ssDNABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • chiasma assembly Source: TAIR
  • DNA metabolic process Source: TAIR
  • DNA recombinase assembly Source: GO_Central
  • meiotic nuclear division Source: TAIR
  • mitotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • strand invasion Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Meiosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein DMC1 homologCurated
Short name:
AtDMC11 Publication
Gene namesi
Name:DMC11 Publication
Synonyms:LIM15
Ordered Locus Names:At3g22880
ORF Names:F5N5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:2084558. AT3G22880.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Strongly reduced fertility and seed numbers due to defects in male and female gametogenesis.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229201 – 344Meiotic recombination protein DMC1 homologAdd BLAST344

Proteomic databases

PaxDbiQ39009.
PRIDEiQ39009.

Expressioni

Tissue specificityi

Expressed in mitotic and/or meiotic tissues. Expressed in roots, leaves and anthers and carpels of young fower buds.1 Publication

Developmental stagei

Cell cycle regulated, peaking at the S phase. It is also expressed at high levels in exponentially growing cells in suspension cultures.1 Publication

Gene expression databases

ExpressionAtlasiQ39009. baseline and differential.
GenevisibleiQ39009. AT.

Interactioni

Subunit structurei

Double stacked ring-shaped homooctamer (By similarity). Interacts with BRCA2A and BRCA2B (PubMed:16415210).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi7192. 6 interactors.
IntActiQ39009. 7 interactors.
MINTiMINT-5222993.
STRINGi3702.AT3G22880.1.

Structurei

3D structure databases

ProteinModelPortaliQ39009.
SMRiQ39009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. DMC1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1434. Eukaryota.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK10872.
OMAiINMADIK.
OrthoDBiEOG09360F79.
PhylomeDBiQ39009.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011940. DMC1_rcmbase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02238. recomb_DMC1. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMASLKAEET SQMQLVEREE NDEDEDLFEM IDKLIAQGIN AGDVKKLQEA
60 70 80 90 100
GIHTCNGLMM HTKKNLTGIK GLSEAKVDKI CEAAEKIVNF GYMTGSDALI
110 120 130 140 150
KRKSVVKITT GCQALDDLLG GGIETSAITE AFGEFRSGKT QLAHTLCVTT
160 170 180 190 200
QLPTNMKGGN GKVAYIDTEG TFRPDRIVPI AERFGMDPGA VLDNIIYARA
210 220 230 240 250
YTYEHQYNLL LGLAAKMSEE PFRILIVDSI IALFRVDFTG RGELADRQQK
260 270 280 290 300
LAQMLSRLIK IAEEFNVAVY MTNQVIADPG GGMFISDPKK PAGGHVLAHA
310 320 330 340
ATIRLLFRKG KGDTRVCKVY DAPNLAEAEA SFQITQGGIA DAKD
Length:344
Mass (Da):37,513
Last modified:July 11, 2002 - v2
Checksum:iE0A97D320A41387D
GO

Sequence cautioni

The sequence BAA08255 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB03033 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104S → L in BAA08255 (PubMed:7584052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45415 Genomic DNA. Translation: BAA08255.1. Sequence problems.
U76670 Genomic DNA. Translation: AAC49617.1.
AP001300 Genomic DNA. Translation: BAB03033.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76687.1.
BT023447 mRNA. Translation: AAY56438.1.
PIRiJC4092.
RefSeqiNP_188928.2. NM_113188.3.
UniGeneiAt.50216.

Genome annotation databases

EnsemblPlantsiAT3G22880.1; AT3G22880.1; AT3G22880.
GeneIDi821860.
GrameneiAT3G22880.1; AT3G22880.1; AT3G22880.
KEGGiath:AT3G22880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45415 Genomic DNA. Translation: BAA08255.1. Sequence problems.
U76670 Genomic DNA. Translation: AAC49617.1.
AP001300 Genomic DNA. Translation: BAB03033.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76687.1.
BT023447 mRNA. Translation: AAY56438.1.
PIRiJC4092.
RefSeqiNP_188928.2. NM_113188.3.
UniGeneiAt.50216.

3D structure databases

ProteinModelPortaliQ39009.
SMRiQ39009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7192. 6 interactors.
IntActiQ39009. 7 interactors.
MINTiMINT-5222993.
STRINGi3702.AT3G22880.1.

Proteomic databases

PaxDbiQ39009.
PRIDEiQ39009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G22880.1; AT3G22880.1; AT3G22880.
GeneIDi821860.
GrameneiAT3G22880.1; AT3G22880.1; AT3G22880.
KEGGiath:AT3G22880.

Organism-specific databases

AraportiAT3G22880.
TAIRilocus:2084558. AT3G22880.

Phylogenomic databases

eggNOGiKOG1434. Eukaryota.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK10872.
OMAiINMADIK.
OrthoDBiEOG09360F79.
PhylomeDBiQ39009.

Miscellaneous databases

PROiPR:Q39009.

Gene expression databases

ExpressionAtlasiQ39009. baseline and differential.
GenevisibleiQ39009. AT.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011940. DMC1_rcmbase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02238. recomb_DMC1. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDMC1_ARATH
AccessioniPrimary (citable) accession number: Q39009
Secondary accession number(s): P93001, Q4V3A9, Q9LIL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: April 12, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.