Reviewed, UniProtKB/Swiss-Prot Q38ZT5 (ARGC_BURS3)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Bcep18194_B3171

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000137115
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q38ZT5-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 62E92B22AEC4E58E	FASTA	315	33,423
	10 20 30 40 50 60 MSQPTVYIDG DQGTTGLLIH ERLRGRIDLQ LVTLPDAERK DPVRRAEAIN AADIAILCLP 70 80 90 100 110 120 DAAAREAVGF IRNPAVRVID ASSAHRTQPD WVYGFPEMAN GHAQTIAHAR RVTNPGCYPT 130 140 150 160 170 180 GAIALLRPLQ QAGLLPRDYP VSIHAVSGYS GGGRAAVDAF ESGDASQAKP LQVYGLALAH 190 200 210 220 230 240 KHVPEIQLHA GLTNRPMFVP AYGAYRQGIV LTVPIELRLL PAGVTGEQLH ACLAHHYADA 250 260 270 280 290 300 RHVDVTPLAD TQAITHLDPQ ALNGTNDMRL GVFVNAEHGQ VLLSAVFDNL GKGASGAAVQ 310 NLDLMLGAAD VAKAA

References

[1]

"Complete sequence of chromosome 2 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000152 Genomic DNA. Translation: ABB13281.1.
RefSeq	YP_373925.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q38ZT5.
Genome annotation databases
GeneID	3754938.
GenomeReviews	Gene locus Bcep18194_B3171 in contig CP000152_GR.
KEGG	bur:Bcep18194_B3171.
NMPDR	fig|269483.3.peg.3079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q38ZT5.
OMA	EIQQHAG.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_B3171-MON.
Family and domain databases
HAMAP	MF_01110. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR010136. AGPR_subtype. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01851. argC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BURS3

Accession

Primary (citable) accession number: Q38ZT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)