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Q38ZL9

- THIM_LACSS

UniProt

Q38ZL9 - THIM_LACSS

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, LCA_0059
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogen By similarity
Binding sitei117 – 1171ATP By similarity
Binding sitei163 – 1631ATP By similarity
Binding sitei190 – 1901Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:LCA_0059
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Hydroxyethylthiazole kinaseUniRule annotation
PRO_1000021515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0059.

Structurei

3D structure databases

ProteinModelPortaliQ38ZL9.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
KOiK00878.
OMAiTISESTY.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38ZL9-1 [UniParc]FASTAAdd to Basket

« Hide

MSKTLLDQIK QANPIITNVA NSVTVDQVAN VQNIIGASPI MSSDPEEAPE    50
MVAIAQALSI NIGTLSTEPI HQMKTLMAEA YRQAKPVVID PVAVSSIHYR 100
QKIIDELLAL GTPQIIRGNA GEIAYLAGLD WQANGIDAGS GEIDLVKVAQ 150
TAAKKQQTTI LLSGPTDIIT DGHHTTKVAN GTPLFQVHVG SGDMLTGLCA 200
AFVAVSPDNP YQAAIDAATT FAVAGQLVAE AMPTPLPGSF YPQLLDCLFN 250
ITAADVQTHA QVTEVLTHE 269
Length:269
Mass (Da):28,312
Last modified:November 22, 2005 - v1
Checksum:i1448AA99CB9480FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI54358.1.
RefSeqiWP_011373773.1. NC_007576.1.
YP_394670.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI54358; CAI54358; LCA_0059.
GeneIDi3777296.
KEGGilsa:LSA0059.
PATRICi22272886. VBILacSak116432_0057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI54358.1 .
RefSeqi WP_011373773.1. NC_007576.1.
YP_394670.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q38ZL9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314315.LSA0059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI54358 ; CAI54358 ; LCA_0059 .
GeneIDi 3777296.
KEGGi lsa:LSA0059.
PATRICi 22272886. VBILacSak116432_0057.

Phylogenomic databases

eggNOGi COG2145.
KOi K00878.
OMAi TISESTY.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiTHIM_LACSS
AccessioniPrimary (citable) accession number: Q38ZL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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