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Q38ZL9 (THIM_LACSS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:LCA_0059
OrganismLactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]
Taxonomic identifier314315 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021515

Sites

Binding site411Substrate; via amide nitrogen By similarity
Binding site1171ATP By similarity
Binding site1631ATP By similarity
Binding site1901Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q38ZL9 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 1448AA99CB9480FB

FASTA26928,312
        10         20         30         40         50         60 
MSKTLLDQIK QANPIITNVA NSVTVDQVAN VQNIIGASPI MSSDPEEAPE MVAIAQALSI 

        70         80         90        100        110        120 
NIGTLSTEPI HQMKTLMAEA YRQAKPVVID PVAVSSIHYR QKIIDELLAL GTPQIIRGNA 

       130        140        150        160        170        180 
GEIAYLAGLD WQANGIDAGS GEIDLVKVAQ TAAKKQQTTI LLSGPTDIIT DGHHTTKVAN 

       190        200        210        220        230        240 
GTPLFQVHVG SGDMLTGLCA AFVAVSPDNP YQAAIDAATT FAVAGQLVAE AMPTPLPGSF 

       250        260 
YPQLLDCLFN ITAADVQTHA QVTEVLTHE 

« Hide

References

[1]"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K."
Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M.
Nat. Biotechnol. 23:1527-1533(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 23K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR936503 Genomic DNA. Translation: CAI54358.1.
RefSeqYP_394670.1. NC_007576.1.

3D structure databases

ProteinModelPortalQ38ZL9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314315.LSA0059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI54358; CAI54358; LCA_0059.
GeneID3777296.
KEGGlsa:LSA0059.
PATRIC22272886. VBILacSak116432_0057.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMATISESTY.
OrthoDBEOG628F8M.

Enzyme and pathway databases

UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_LACSS
AccessionPrimary (citable) accession number: Q38ZL9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways