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Reviewed, UniProtKB/Swiss-Prot Q38YF0 (GUAC_LACSS)

Last modified February 9, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    GMP reductase
    EC=1.7.1.7
Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductase
      Short name=Guanosine monophosphate reductase
Gene names
Name: guaC
Ordered Locus Names: LCA_0476
OrganismLactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]
Taxonomic identifier314315 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

purine nucleotide metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325GMP reductase HAMAP MF_01511
PRO_0000292052

Regions

Nucleotide binding203 – 22624NADP Potential

Sites

Active site1741Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q38YF0-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: FC050439A34AA543

FASTA32536,067
        10         20         30         40         50         60 
MDVFDYEDVQ LIPNKCIVKS RSEIDTTVRF GSETFKIPVV PANMQTIIDE PLAIWLAENH 

        70         80         90        100        110        120 
YFYVMHRFQP EKRPAFIKMM HERNLFASIS VGVKDDEFDF INQLAQDNLI PEYITIDIAH 

       130        140        150        160        170        180 
GHSQVVIDMI QHIKKVLPKS FVIAGNVGTP EAVRDLERAG ADATKVGIGP GKVCITKIKT 

       190        200        210        220        230        240 
GFGTGGWQLG ALRWCAKAAT KPIIADGGIR TNGDIAKSIR FGANMVMIGS LFAGHTESPG 

       250        260        270        280        290        300 
ELVEEDGQQF KEYFGSASEF QKGTHQNVEG KRILVPYKGS ISDTLTEMRQ DLQSSISYAG 

       310        320 
GKRLSALRKV DYVLVRHSIF NGDML 

« Hide

References

[1]"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K."
Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M.
Nat. Biotechnol. 23:1527-1533(2005) [PubMed: 16273110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR936503 Genomic DNA. Translation: CAI54777.1.
RefSeqYP_395089.1.

3D structure databases

HSSPHSSP built from PDB template 1YPF based on UniProtKB Q81JJ9.
SMRQ38YF0. Positions 2-320.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ38YF0.

Genome annotation databases

GeneID3777651.
GenomeReviewsGene locus LCA_0476 in contig CR936503_GR.
KEGGlsa:LSA0476.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHBG298985.
OMAFAGHEES.
PhylomeDBQ38YF0.

Enzyme and pathway databases

BioCycLSAK314315:LSA0476-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_LACSS
AccessionPrimary (citable) accession number: Q38YF0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 22, 2005
Last modified: February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents