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Q38XW3

- PUR9_LACSS

UniProt

Q38XW3 - PUR9_LACSS

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LCA_0662
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLSAK314315:GCKE-1229-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LCA_0662
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018903Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0662.

Structurei

3D structure databases

ProteinModelPortaliQ38XW3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38XW3-1 [UniParc]FASTAAdd to Basket

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MKRALISVSD KTGIVAFAQG LVAADFEIIS TGGTFSVLEK AGVPVTPIDE    50
VTHFPEMLDG RVKTLHPNIH GGLLAKRDEP THMAALAEHE IAPIDLVCVN 100
LYPFKETIQK PEITQEQAIE QIDIGGPSML RSAAKNFKSV YVVVDQADYD 150
ETLAQLQQDD VTYRRHLAAK AFRHTAAYDS LIAGYLSDAD AVEFPEKLSL 200
TYDFKQALRY GENAHQKAAF YQSALPSAFS IAAAHQLHGK ELSYNNIKDA 250
DAAIKVAAEF SEPCVVAMKH MNPCGVGLGT TIYDAWQKAF AADSVSIFGG 300
IIALNREVDV QTANALHELF LEIVIAPSFA PEALAILEKK KNIRLMTLDF 350
EQAAKADRFE TVSVLGGLLV QERDRLTDQA SELKTVTTKA PTEDEKEALL 400
FAQRVVKHVK SNAIVVATKG QTLGVGAGQM NRVGSVKIAL EQALANGMQA 450
PFVLASDAFF PMDDSVAYAA EHGITAIIQP GGSIKDQDSI DMANQKGVSM 500
VFTNRRHFKH 510
Length:510
Mass (Da):55,410
Last modified:November 22, 2005 - v1
Checksum:i2A9F090BB903CC6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI54966.1.
RefSeqiWP_011374371.1. NC_007576.1.
YP_395277.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI54966; CAI54966; LCA_0662.
GeneIDi3777559.
KEGGilsa:LSA0662.
PATRICi22274144. VBILacSak116432_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI54966.1 .
RefSeqi WP_011374371.1. NC_007576.1.
YP_395277.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q38XW3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 314315.LSA0662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI54966 ; CAI54966 ; LCA_0662 .
GeneIDi 3777559.
KEGGi lsa:LSA0662.
PATRICi 22274144. VBILacSak116432_0640.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LSAK314315:GCKE-1229-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiPUR9_LACSS
AccessioniPrimary (citable) accession number: Q38XW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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