Q38X91 (AROD_LACSS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	LCA_0889

Organism

Lactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]

Taxonomic identifier

314315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325527
Sites
	Active site	132	1	Proton acceptor By similarity
	Active site	160	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q38X91 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: F008D727E40A2626	FASTA	240	26,502
	10 20 30 40 50 60 MHLEFTTGQT QTAVSLMPRH LDDCLRELIL INQKKDAIDI LEWRLDYWQA PAQLLTAAEK 70 80 90 100 110 120 IAALDLPLIL TVRTTNDGGL ASAQDYLTYY APLIKAHIGQ AIDLEWSLAA EQRHQLAELA 130 140 150 160 170 180 HQQHYQVLLS HHDTVQTPDN DTLRTQLLAM QADPDADLLK LATTAQSPAD TTRLLAATQS 190 200 210 220 230 240 FTHQFDKPLT TMAMSEFGVA SRIFGGQFGS AISFGYLETP SAPGQLPIEQ LKGLLTTNQA

References

[1]

"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K." Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M. Nat. Biotechnol. 23:1527-1533(2005) [PubMed: 16273110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 23K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936503 Genomic DNA. Translation: CAI55190.1.
RefSeq	YP_395499.1. NC_007576.1.
3D structure databases
ProteinModelPortal	Q38X91.
ModBase	Search...
Protein-protein interaction databases
STRING	Q38X91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3777801.
GenomeReviews	Gene locus LCA_0889 in contig CR936503_GR.
KEGG	lsa:LSA0889.
PATRIC	22274588. VBILacSak116432_0860.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
OMA	IEGGERE.
PhylomeDB	Q38X91.
Enzyme and pathway databases
BioCyc	LSAK314315:LSA0889-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_LACSS

Accession

Primary (citable) accession number: Q38X91

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program