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Q38X32

- FTHS_LACSS

UniProt

Q38X32 - FTHS_LACSS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LCA_0947
    OrganismiLactobacillus sakei subsp. sakei (strain 23K)
    Taxonomic identifieri314315 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000002707: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000293042Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314315.LSA0947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38X32.
    SMRiQ38X32. Positions 3-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q38X32-1 [UniParc]FASTAAdd to Basket

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    MSDIQIAQAN EATEMKSITA IAEQIGLQAT DIEQYGPYKA KLNFQAINRL    50
    KEKEDGKLVL VTSINPTPAG EGKSTVTVGL GDALRQLDQS AVIALREPSL 100
    GPVMGMKGGA TGGGYAQVVP MADINLHFTG DMHALTATVN TLAALIDNHL 150
    QQGNVLNIDP RRIIWKRALD INDRALRQVV IGLGGPVQGM PRQDGFDITV 200
    ASELMAILCL ATDITDLKNR ISKIVIGYNY DREPVTVGDL EVTGAIAMLL 250
    KDALKPNMVQ TLEHTPALVH GGPFANIAHG CNSILATQTA LKLGDIAITE 300
    AGFGADLGAE KFLDIKVPQL GKTPDTIVIV ATIRALKYNG GVALADLTTE 350
    NLDALKAGFS NLAKHIANMQ RYGVPVVVSV NEFTSDTAAE VQLLQDLCQA 400
    MKVTAVPTSV WANGGQGGIE LAKAVLAALQ QPKAFKPLYD PQADIKSKLT 450
    TVVTEIYGGR DVVFEGKAIN QLKQIEKNGW AHLPVCIAKT QYSLSDDPKA 500
    LGAPSDFTIH VRELIPKLGA GFIVAMTGAV LTMPGLPKKP AALNMDVTAD 550
    GQISGLF 557
    Length:557
    Mass (Da):59,070
    Last modified:November 22, 2005 - v1
    Checksum:i215009D86ECF2C63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936503 Genomic DNA. Translation: CAI55249.1.
    RefSeqiWP_011374649.1. NC_007576.1.
    YP_395558.1. NC_007576.1.

    Genome annotation databases

    EnsemblBacteriaiCAI55249; CAI55249; LCA_0947.
    GeneIDi3777631.
    KEGGilsa:LSA0947.
    PATRICi22274702. VBILacSak116432_0917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936503 Genomic DNA. Translation: CAI55249.1 .
    RefSeqi WP_011374649.1. NC_007576.1.
    YP_395558.1. NC_007576.1.

    3D structure databases

    ProteinModelPortali Q38X32.
    SMRi Q38X32. Positions 3-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314315.LSA0947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI55249 ; CAI55249 ; LCA_0947 .
    GeneIDi 3777631.
    KEGGi lsa:LSA0947.
    PATRICi 22274702. VBILacSak116432_0917.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 23K.

    Entry informationi

    Entry nameiFTHS_LACSS
    AccessioniPrimary (citable) accession number: Q38X32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3