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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LCA_0947
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000293042Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0947.

Structurei

3D structure databases

ProteinModelPortaliQ38X32.
SMRiQ38X32. Positions 3-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38X32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIQIAQAN EATEMKSITA IAEQIGLQAT DIEQYGPYKA KLNFQAINRL
60 70 80 90 100
KEKEDGKLVL VTSINPTPAG EGKSTVTVGL GDALRQLDQS AVIALREPSL
110 120 130 140 150
GPVMGMKGGA TGGGYAQVVP MADINLHFTG DMHALTATVN TLAALIDNHL
160 170 180 190 200
QQGNVLNIDP RRIIWKRALD INDRALRQVV IGLGGPVQGM PRQDGFDITV
210 220 230 240 250
ASELMAILCL ATDITDLKNR ISKIVIGYNY DREPVTVGDL EVTGAIAMLL
260 270 280 290 300
KDALKPNMVQ TLEHTPALVH GGPFANIAHG CNSILATQTA LKLGDIAITE
310 320 330 340 350
AGFGADLGAE KFLDIKVPQL GKTPDTIVIV ATIRALKYNG GVALADLTTE
360 370 380 390 400
NLDALKAGFS NLAKHIANMQ RYGVPVVVSV NEFTSDTAAE VQLLQDLCQA
410 420 430 440 450
MKVTAVPTSV WANGGQGGIE LAKAVLAALQ QPKAFKPLYD PQADIKSKLT
460 470 480 490 500
TVVTEIYGGR DVVFEGKAIN QLKQIEKNGW AHLPVCIAKT QYSLSDDPKA
510 520 530 540 550
LGAPSDFTIH VRELIPKLGA GFIVAMTGAV LTMPGLPKKP AALNMDVTAD

GQISGLF
Length:557
Mass (Da):59,070
Last modified:November 22, 2005 - v1
Checksum:i215009D86ECF2C63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936503 Genomic DNA. Translation: CAI55249.1.
RefSeqiWP_011374649.1. NC_007576.1.
YP_395558.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI55249; CAI55249; LCA_0947.
KEGGilsa:LSA0947.
PATRICi22274702. VBILacSak116432_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936503 Genomic DNA. Translation: CAI55249.1.
RefSeqiWP_011374649.1. NC_007576.1.
YP_395558.1. NC_007576.1.

3D structure databases

ProteinModelPortaliQ38X32.
SMRiQ38X32. Positions 3-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314315.LSA0947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI55249; CAI55249; LCA_0947.
KEGGilsa:LSA0947.
PATRICi22274702. VBILacSak116432_0917.

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiFTHS_LACSS
AccessioniPrimary (citable) accession number: Q38X32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: April 29, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.