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Q38X32

- FTHS_LACSS

UniProt

Q38X32 - FTHS_LACSS

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LCA_0947
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LCA_0947
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293042Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0947.

Structurei

3D structure databases

ProteinModelPortaliQ38X32.
SMRiQ38X32. Positions 3-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38X32-1 [UniParc]FASTAAdd to Basket

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MSDIQIAQAN EATEMKSITA IAEQIGLQAT DIEQYGPYKA KLNFQAINRL    50
KEKEDGKLVL VTSINPTPAG EGKSTVTVGL GDALRQLDQS AVIALREPSL 100
GPVMGMKGGA TGGGYAQVVP MADINLHFTG DMHALTATVN TLAALIDNHL 150
QQGNVLNIDP RRIIWKRALD INDRALRQVV IGLGGPVQGM PRQDGFDITV 200
ASELMAILCL ATDITDLKNR ISKIVIGYNY DREPVTVGDL EVTGAIAMLL 250
KDALKPNMVQ TLEHTPALVH GGPFANIAHG CNSILATQTA LKLGDIAITE 300
AGFGADLGAE KFLDIKVPQL GKTPDTIVIV ATIRALKYNG GVALADLTTE 350
NLDALKAGFS NLAKHIANMQ RYGVPVVVSV NEFTSDTAAE VQLLQDLCQA 400
MKVTAVPTSV WANGGQGGIE LAKAVLAALQ QPKAFKPLYD PQADIKSKLT 450
TVVTEIYGGR DVVFEGKAIN QLKQIEKNGW AHLPVCIAKT QYSLSDDPKA 500
LGAPSDFTIH VRELIPKLGA GFIVAMTGAV LTMPGLPKKP AALNMDVTAD 550
GQISGLF 557
Length:557
Mass (Da):59,070
Last modified:November 22, 2005 - v1
Checksum:i215009D86ECF2C63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55249.1.
RefSeqiWP_011374649.1. NC_007576.1.
YP_395558.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI55249; CAI55249; LCA_0947.
GeneIDi3777631.
KEGGilsa:LSA0947.
PATRICi22274702. VBILacSak116432_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55249.1 .
RefSeqi WP_011374649.1. NC_007576.1.
YP_395558.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q38X32.
SMRi Q38X32. Positions 3-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314315.LSA0947.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI55249 ; CAI55249 ; LCA_0947 .
GeneIDi 3777631.
KEGGi lsa:LSA0947.
PATRICi 22274702. VBILacSak116432_0917.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiFTHS_LACSS
AccessioniPrimary (citable) accession number: Q38X32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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