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Q38X32 (FTHS_LACSS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LCA_0947
OrganismLactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]
Taxonomic identifier314315 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293042

Regions

Nucleotide binding67 – 748ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q38X32 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 215009D86ECF2C63

FASTA55759,070
        10         20         30         40         50         60 
MSDIQIAQAN EATEMKSITA IAEQIGLQAT DIEQYGPYKA KLNFQAINRL KEKEDGKLVL 

        70         80         90        100        110        120 
VTSINPTPAG EGKSTVTVGL GDALRQLDQS AVIALREPSL GPVMGMKGGA TGGGYAQVVP 

       130        140        150        160        170        180 
MADINLHFTG DMHALTATVN TLAALIDNHL QQGNVLNIDP RRIIWKRALD INDRALRQVV 

       190        200        210        220        230        240 
IGLGGPVQGM PRQDGFDITV ASELMAILCL ATDITDLKNR ISKIVIGYNY DREPVTVGDL 

       250        260        270        280        290        300 
EVTGAIAMLL KDALKPNMVQ TLEHTPALVH GGPFANIAHG CNSILATQTA LKLGDIAITE 

       310        320        330        340        350        360 
AGFGADLGAE KFLDIKVPQL GKTPDTIVIV ATIRALKYNG GVALADLTTE NLDALKAGFS 

       370        380        390        400        410        420 
NLAKHIANMQ RYGVPVVVSV NEFTSDTAAE VQLLQDLCQA MKVTAVPTSV WANGGQGGIE 

       430        440        450        460        470        480 
LAKAVLAALQ QPKAFKPLYD PQADIKSKLT TVVTEIYGGR DVVFEGKAIN QLKQIEKNGW 

       490        500        510        520        530        540 
AHLPVCIAKT QYSLSDDPKA LGAPSDFTIH VRELIPKLGA GFIVAMTGAV LTMPGLPKKP 

       550 
AALNMDVTAD GQISGLF 

« Hide

References

[1]"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K."
Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M.
Nat. Biotechnol. 23:1527-1533(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 23K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR936503 Genomic DNA. Translation: CAI55249.1.
RefSeqYP_395558.1. NC_007576.1.

3D structure databases

ProteinModelPortalQ38X32.
SMRQ38X32. Positions 3-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314315.LSA0947.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI55249; CAI55249; LCA_0947.
GeneID3777631.
KEGGlsa:LSA0947.
PATRIC22274702. VBILacSak116432_0917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACSS
AccessionPrimary (citable) accession number: Q38X32
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways