Q38X27 (PYRB_LACSS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	LCA_0952

Organism

Lactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]

Taxonomic identifier

314315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321112

Sequences

	Sequence		Length	Mass (Da)
	Q38X27 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 09559B35BD646E71	FASTA	305	34,329
	10 20 30 40 50 60 MTNQTAIVSV EQLTNSSVLN LIERAEAFKQ GATCELTRPV YAMNLFFENS TRTKTSFEMA 70 80 90 100 110 120 ERKLGLSVMS FEAETSSVSK GETLSDTLKT VQAIGVDFVA VRHPQNYYYD DLLADPAFHL 130 140 150 160 170 180 ALANGGDGSG QHPSQCLLDM MTIHEEFGHF DGLKVVICGD LRHSRVAKSN MQLLKRLGAQ 190 200 210 220 230 240 LYFAGPEEWF TAEFNDYGQH VALDSILDQV DVVMLLRIQH ERFDSAETMT DEAFHVKYGL 250 260 270 280 290 300 TAQRAAQLKA STIWLHPAPV NRDVEIADEL VEAPQSRIFK QMHNGVFMRM AMIEYLLKQK NLIKD

References

[1]

"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K." Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M. Nat. Biotechnol. 23:1527-1533(2005) [PubMed: 16273110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 23K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936503 Genomic DNA. Translation: CAI55254.1.
RefSeq	YP_395563.1. NC_007576.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q38X27.
ModBase	Search...
Protein-protein interaction databases
STRING	Q38X27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3777486.
GenomeReviews	Gene locus LCA_0952 in contig CR936503_GR.
KEGG	lsa:LSA0952.
PATRIC	22274712. VBILacSak116432_0922.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	DLYTIRQ.
PhylomeDB	Q38X27.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	LSAK314315:LSA0952-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_LACSS

Accession

Primary (citable) accession number: Q38X27

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program