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Q38WJ3

- KITH_LACSS

UniProt

Q38WJ3 - KITH_LACSS

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Protein
Thymidine kinase
Gene
tdk, LCA_1138
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor Reviewed prediction
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity
Metal bindingi180 – 1801Zinc By similarity
Metal bindingi183 – 1831Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarity
Nucleotide bindingi85 – 884ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:LCA_1138
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Thymidine kinaseUniRule annotation
PRO_0000242794Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi314315.LSA1138.

Structurei

3D structure databases

ProteinModelPortaliQ38WJ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38WJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLFFRYGA MNSGKSIEIL KVAHNYEEQN KSVIILTSGI DNRDGVGIVS    50
SRIGLKREAT PIFSDTNIYE LVEATNPDAA CVLIDESQFL ERHHVIEAAK 100
VVDDLNIPVM AFGLKNDFKN ELFEGSKYLL LFANKIEEMK TICWFCRKKA 150
IMNLRMNNGL PVYTGEQIQI GGNEAYYPVC RKHYFNPPIQ EEIEKEG 197
Length:197
Mass (Da):22,401
Last modified:November 22, 2005 - v1
Checksum:i7B0BEDA5C4B6AF0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55439.1.
RefSeqiYP_395747.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI55439; CAI55439; LCA_1138.
GeneIDi3777689.
KEGGilsa:LSA1138.
PATRICi22275080. VBILacSak116432_1106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55439.1 .
RefSeqi YP_395747.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q38WJ3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 314315.LSA1138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI55439 ; CAI55439 ; LCA_1138 .
GeneIDi 3777689.
KEGGi lsa:LSA1138.
PATRICi 22275080. VBILacSak116432_1106.

Phylogenomic databases

eggNOGi COG1435.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiKITH_LACSS
AccessioniPrimary (citable) accession number: Q38WJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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