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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:LCA_1157
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000002707 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178151 – 140Methylglyoxal synthaseAdd BLAST140

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA1157.

Structurei

3D structure databases

ProteinModelPortaliQ38WH3.
SMRiQ38WH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140MGS-likeUniRule annotationAdd BLAST140

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni54 – 55Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
KOiK01734.
OMAiRACDVHN.
OrthoDBiPOG091H04UH.

Family and domain databases

CDDicd01422. MGS. 1 hit.
Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth. 1 hit.
InterProiView protein in InterPro
IPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
IPR036914. MGS-like_dom_sf.
PANTHERiPTHR30492. PTHR30492. 1 hit.
PfamiView protein in Pfam
PF02142. MGS. 1 hit.
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiView protein in SMART
SM00851. MGS. 1 hit.
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiView protein in PROSITE
PS01335. METHYLGLYOXAL_SYNTH. 1 hit.
PS51855. MGS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38WH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALIAHDR QKPLIVKLAT AYQPILAQHE LFATGTTGQK IIDATGLSVK
60 70 80 90 100
RFKSGPLGGD QQIGALISEN KMDLVIFLRD PLTAQPHEPD VNALIRLSDV
110 120 130 140
YEVPLATNIG TAEVLLRGLD QGLMAFREVV HDQDSNPINL
Length:140
Mass (Da):15,275
Last modified:November 22, 2005 - v1
Checksum:iB6C063ED6E2DECA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936503 Genomic DNA. Translation: CAI55459.1.
RefSeqiWP_011374855.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI55459; CAI55459; LCA_1157.
GeneIDi29637137.
KEGGilsa:LCA_1157.

Similar proteinsi

Entry informationi

Entry nameiMGSA_LACSS
AccessioniPrimary (citable) accession number: Q38WH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome