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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donorUniRule annotation1
Active sitei311UniRule annotation1
Active sitei425UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciLSAK314315:G1GI3-1175-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LCA_1179
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000002707 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002309191 – 448Glucose-6-phosphate isomeraseAdd BLAST448

Proteomic databases

PRIDEiQ38WF1

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA1179

Structurei

3D structure databases

ProteinModelPortaliQ38WF1
SMRiQ38WF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
KOiK01810
OMAiVERCKAM
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q38WF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHISFDASR LDKFVQSNEL AEMQAMVNAA DSQLREGTGA GNDFRGFLDL
60 70 80 90 100
PVNYDKDEFA RIKEAVAKIK SDSEIFVAIG IGGSYLGAKA AIDFLNNTFY
110 120 130 140 150
NMLPAEQRDF PQVLFAGNSI SSSYLSDLVN LIGDRDFSIN VISKSGTTTE
160 170 180 190 200
PSIAFRVLKD KLIKKYGKEE AKGRIYATTD RAKGALKTES DAEGYAEFVV
210 220 230 240 250
PDDIGGRFSV LTAVGLLPIA VAGGDIDQLM KGAADARLEY TDTDVTKNDA
260 270 280 290 300
YKYAALRNIL YRKGYTTELL ENYEPTLQYF SEWWKQLMGE SEGKDQKGIY
310 320 330 340 350
PSSANFSTDL HSLGQYIQEG RRNLMETVVN VEKPNSDIDI PADEQNLDGL
360 370 380 390 400
GYLEGHTMDF VNKKAYQGVV LAHTDGGVPV MTVNIPDQTA YTLGYMIYFF
410 420 430 440
EMAVSISGYL NGINPFNQPG VEAYKKNMFA LLGKPGFEEL GKELNERL
Length:448
Mass (Da):49,499
Last modified:November 22, 2005 - v1
Checksum:iD93952BC6241D54C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936503 Genomic DNA Translation: CAI55481.1
RefSeqiWP_011374877.1, NC_007576.1

Genome annotation databases

EnsemblBacteriaiCAI55481; CAI55481; LCA_1179
GeneIDi29637116
KEGGilsa:LCA_1179

Similar proteinsi

Entry informationi

Entry nameiG6PI_LACSS
AccessioniPrimary (citable) accession number: Q38WF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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