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Q38VP5

- SYL_LACSS

UniProt

Q38VP5 - SYL_LACSS

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei578 – 5781ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LCA_1436
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine--tRNA ligasePRO_1000009362Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA1436.

Structurei

3D structure databases

ProteinModelPortaliQ38VP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi575 – 5795"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38VP5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYDHRAVEQ KWQAYWQSHK SFKTTEDKDK KNFYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGF NVLHPMGWDA FGLPAEQYAL DTGNNPADFT
110 120 130 140 150
QKNINTFKRQ INSLGFSYDW DREVNTTDPD FYKWTQWIFE KMYEKGLAYE
160 170 180 190 200
AEVAVNWSPD LGTVVANEEV IDGKTERGGY PVYRKPMRQW MLKITAYADR
210 220 230 240 250
LIDDLDLVDW PESVKDMQRN WIGRSKGAEV SFAVENHDAN IDVFTTRADT
260 270 280 290 300
MFGVSYIVMA PEHKLVADIT TPEQKAAVDA YLKEIEHKSD LERTDLAKDK
310 320 330 340 350
TGAFTGAYAI NPVNGERLPI WISDYVLASY GTGAVMAVPA HDPRDWEFAK
360 370 380 390 400
KFGLPLKPVV SGGNPEEAVH TEPGVMINSD FLDGLDKQAA IDKMIPWLVE
410 420 430 440 450
HKVGHEQISY KLRDWLFSRQ RYWGEPIPII HWEDGTTSVV PEDQLPLELP
460 470 480 490 500
LTSDIKPSGT GESPLANLTD WLNVTDENGR KGRRETNTMP QWAGSSWYYL
510 520 530 540 550
RYIDPKNPDK LADFDKLKDW LPVDMYIGGA EHAVLHLLYV RFWHKFLYDI
560 570 580 590 600
GVVPTKEPFQ HLYNQGMILG DNHEKMSKSK GNVVNPDDVV DRFGADTLRL
610 620 630 640 650
YEMFMGPLDA SISWSEKGLA GARKFLDRVW RLYTEEDTDE NDQLSSKIVA
660 670 680 690 700
DNNDQLKKVY NETVKKVTED FESMHFNVAI SQLMVFINDA YKADTFPREY
710 720 730 740 750
AEGFVKLLAP IAPHMMEELW AMLGHDDSIS YVDWPTFDPA ALIANEVEVI
760 770 780 790 800
FQVNGKLKAK VTVAKDTPKE ELEAMAKANE KVAEFIADKT VRKVIAIPNK

LVNIVAN
Length:807
Mass (Da):92,127
Last modified:November 22, 2005 - v1
Checksum:i38344640F2DCE7B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55738.1.
RefSeqiYP_396045.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI55738; CAI55738; LCA_1436.
GeneIDi3777995.
KEGGilsa:LSA1436.
PATRICi22275678. VBILacSak116432_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936503 Genomic DNA. Translation: CAI55738.1 .
RefSeqi YP_396045.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q38VP5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314315.LSA1436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI55738 ; CAI55738 ; LCA_1436 .
GeneIDi 3777995.
KEGGi lsa:LSA1436.
PATRICi 22275678. VBILacSak116432_1400.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiSYL_LACSS
AccessioniPrimary (citable) accession number: Q38VP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3