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Q38SD2

- LRRK1_HUMAN

UniProt

Q38SD2 - LRRK1_HUMAN

Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

LRRK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Magnesium or manganese.1 Publication

    Enzyme regulationi

    Binding of GTP stimulates kinase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1270 – 12701ATPPROSITE-ProRule annotation
    Active sitei1386 – 13861Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1248 – 12569ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GTP binding Source: UniProtKB-KW
    3. identical protein binding Source: IntAct
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: IntAct
    6. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ38SD2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat serine/threonine-protein kinase 1 (EC:2.7.11.1)
    Gene namesi
    Name:LRRK1Imported
    Synonyms:KIAA1790Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18608. LRRK1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi651 – 6511K → A: Loss of GTP/GDP-binding. 1 Publication
    Mutagenesisi746 – 7461K → G: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication
    Mutagenesisi1022 – 10221F → C: No effect on GTP-binding but loss of subsequent stimulation of kinase activity. 1 Publication
    Mutagenesisi1270 – 12701K → W: Loss of autophosphorylation. 1 Publication
    Mutagenesisi1412 – 14121I → T: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134892363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20152015Leucine-rich repeat serine/threonine-protein kinase 1PRO_0000233377Add
    BLAST

    Proteomic databases

    MaxQBiQ38SD2.
    PaxDbiQ38SD2.
    PRIDEiQ38SD2.

    PTM databases

    PhosphoSiteiQ38SD2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ38SD2.
    BgeeiQ38SD2.
    CleanExiHS_LRRK1.
    GenevestigatoriQ38SD2.

    Organism-specific databases

    HPAiHPA010537.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-1050422,EBI-1050422
    ABL1P005193EBI-1050422,EBI-375543
    BAG5Q9UL153EBI-1050422,EBI-356517
    DAPK1P533552EBI-1050422,EBI-358616
    EGFRP005332EBI-1050422,EBI-297353
    LRRK2Q5S0075EBI-1050422,EBI-5323863

    Protein-protein interaction databases

    BioGridi122823. 31 interactions.
    IntActiQ38SD2. 78 interactions.
    STRINGi9606.ENSP00000373600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38SD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati86 – 11631ANK 1Add
    BLAST
    Repeati119 – 14830ANK 2Add
    BLAST
    Repeati152 – 18231ANK 3Add
    BLAST
    Repeati193 – 22230ANK 4Add
    BLAST
    Repeati279 – 30022LRR 1Add
    BLAST
    Repeati303 – 32422LRR 2Add
    BLAST
    Repeati330 – 35122LRR 3Add
    BLAST
    Repeati353 – 37422LRR 4Add
    BLAST
    Repeati381 – 40222LRR 5Add
    BLAST
    Repeati405 – 42622LRR 6Add
    BLAST
    Repeati427 – 44721LRR 7Add
    BLAST
    Repeati451 – 47222LRR 8Add
    BLAST
    Repeati474 – 49522LRR 9Add
    BLAST
    Repeati498 – 51922LRR 10Add
    BLAST
    Repeati549 – 57022LRR 11Add
    BLAST
    Repeati572 – 59423LRR 12Add
    BLAST
    Repeati596 – 61722LRR 13Add
    BLAST
    Domaini632 – 826195RocPROSITE-ProRule annotationAdd
    BLAST
    Domaini1242 – 1525284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Sequence Analysis
    Contains 13 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 Roc domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG1100.
    HOVERGENiHBG081936.
    KOiK08843.
    OMAiFEEENAT.
    OrthoDBiEOG761BST.
    PhylomeDBiQ38SD2.
    TreeFamiTF313679.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR000719. Prot_kinase_dom.
    IPR020859. ROC_GTPase.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF08477. Miro. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    SM00369. LRR_TYP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS51450. LRR. 11 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS51424. ROC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q38SD2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGMSQRPPS MYWCVGPEES AVCPERAMET LNGAGDTGGK PSTRGGDPAA     50
    RSRRTEGIRA AYRRGDRGGA RDLLEEACDQ CASQLEKGQL LSIPAAYGDL 100
    EMVRYLLSKR LVELPTEPTD DNPAVVAAYF GHTAVVQELL ESLPGPCSPQ 150
    RLLNWMLALA CQRGHLGVVK LLVLTHGADP ESYAVRKNEF PVIVRLPLYA 200
    AIKSGNEDIA IFLLRHGAYF CSYILLDSPD PSKHLLRKYF IEASPLPSSY 250
    PGKTALRVKW SHLRLPWVDL DWLIDISCQI TELDLSANCL ATLPSVIPWG 300
    LINLRKLNLS DNHLGELPGV QSSDEIICSR LLEIDISSNK LSHLPPGFLH 350
    LSKLQKLTAS KNCLEKLFEE ENATNWIGLR KLQELDISDN KLTELPALFL 400
    HSFKSLNSLN VSRNNLKVFP DPWACPLKCC KASRNALECL PDKMAVFWKN 450
    HLKDVDFSEN ALKEVPLGLF QLDALMFLRL QGNQLAALPP QEKWTCRQLK 500
    TLDLSRNQLG KNEDGLKTKR IAFFTTRGRQ RSGTEAASVL EFPAFLSESL 550
    EVLCLNDNHL DTVPPSVCLL KSLSELYLGN NPGLRELPPE LGQLGNLWQL 600
    DTEDLTISNV PAEIQKEGPK AMLSYLRAQL RKAEKCKLMK MIIVGPPRQG 650
    KSTLLEILQT GRAPQVVHGE ATIRTTKWEL QRPAGSRAKV ESVEFNVWDI 700
    GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA 750
    VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH 800
    LHEISCKSLE GQEGLRQLIF HVTCSMKDVG STIGCQRLAG RLIPRSYLSL 850
    QEAVLAEQQR RSRDDDVQYL TDRQLEQLVE QTPDNDIKDY EDLQSAISFL 900
    IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIR 950
    AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG 1000
    LDTHGMRHPT ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK 1050
    KNTKSRNRKV TIYSFTGNQR NRCSTFRVKR NQTIYWQEGL LVTFDGGYLS 1100
    VESSDVNWKK KKSGGMKIVC QSEVRDFSAM AFITDHVNSL IDQWFPALTA 1150
    TESDGTPLME QYVPCPVCET AWAQHTDPSE KSEDVQYFDM EDCVLTAIER 1200
    DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH SEDEGSVLGQ 1250
    GGSGTVIYRA RYQGQPVAVK RFHIKKFKNF ANVPADTMLR HLRATDAMKN 1300
    FSEFRQEASM LHALQHPCIV ALIGISIHPL CFALELAPLS SLNTVLSENA 1350
    RDSSFIPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLDVK 1400
    EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY 1450
    GMVLYELLSG QRPALGHHQL QIAKKLSKGI RPVLGQPEEV QFRRLQALMM 1500
    ECWDTKPEKR PLALSVVSQM KDPTFATFMY ELCCGKQTAF FSSQGQEYTV 1550
    VFWDGKEESR NYTVVNTEKG LMEVQRMCCP GMKVSCQLQV QRSLWTATED 1600
    QKIYIYTLKG MCPLNTPQQA LDTPAVVTCF LAVPVIKKNS YLVLAGLADG 1650
    LVAVFPVVRG TPKDSCSYLC SHTANRSKFS IADEDARQNP YPVKAMEVVN 1700
    SGSEVWYSNG PGLLVIDCAS LEICRRLEPY MAPSMVTSVV CSSEGRGEEV 1750
    VWCLDDKANS LVMYHSTTYQ LCARYFCGVP SPLRDMFPVR PLDTEPPAAS 1800
    HTANPKVPEG DSIADVSIMY SEELGTQILI HQESLTDYCS MSSYSSSPPR 1850
    QAARSPSSLP SSPASSSSVP FSTDCEDSDM LHTPGAASDR SEHDLTPMDG 1900
    ETFSQHLQAV KILAVRDLIW VPRRGGDVIV IGLEKDSGAQ RGRVIAVLKA 1950
    RELTPHGVLV DAAVVAKDTV VCTFENENTE WCLAVWRGWG AREFDIFYQS 2000
    YEELGRLEAC TRKRR 2015

    Note: No experimental confirmation available.Curated

    Length:2,015
    Mass (Da):225,393
    Last modified:November 30, 2010 - v3
    Checksum:i38E77EDC7C84583B
    GO
    Isoform 21 Publication (identifier: Q38SD2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-264: ALRVKWSHLR → VSSHCLWSVF
         265-2015: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:264
    Mass (Da):28,848
    Checksum:i8E95B1F50F1DB2E4
    GO

    Sequence cautioni

    The sequence AAY67799.1 differs from that shown. Reason: The cDNA contains a duplication of exon 3.
    The sequence BAB15547.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC85472.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031K → R in BAC85472. (PubMed:14702039)Curated
    Sequence conflicti1938 – 19381G → E in AAH66655. (PubMed:15489334)Curated
    Sequence conflicti1938 – 19381G → E in BAB47419. (PubMed:11347906)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1803 – 18031A → T.1 Publication
    VAR_040674
    Natural varianti1824 – 18241L → F.1 Publication
    VAR_040675
    Natural varianti1847 – 18471S → N.1 Publication
    VAR_040676
    Natural varianti1927 – 19271D → G.1 Publication
    VAR_040677

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 26410ALRVKWSHLR → VSSHCLWSVF in isoform 2. 1 PublicationVSP_040119
    Alternative sequencei265 – 20151751Missing in isoform 2. 1 PublicationVSP_040120Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC090907 Genomic DNA. No translation available.
    BC066655 mRNA. Translation: AAH66655.1.
    BC068080 mRNA. Translation: AAH68080.1.
    DQ013130 mRNA. Translation: AAY67799.1. Sequence problems.
    AK026772 mRNA. Translation: BAB15547.1. Different initiation.
    AK130975 mRNA. Translation: BAC85472.1. Different initiation.
    AK131075 mRNA. Translation: BAC85125.1.
    AB058693 mRNA. Translation: BAB47419.1.
    CCDSiCCDS42086.1. [Q38SD2-1]
    RefSeqiNP_078928.3. NM_024652.3. [Q38SD2-1]
    UniGeneiHs.407918.

    Genome annotation databases

    EnsembliENST00000388948; ENSP00000373600; ENSG00000154237. [Q38SD2-1]
    ENST00000532029; ENSP00000433268; ENSG00000154237. [Q38SD2-2]
    GeneIDi79705.
    KEGGihsa:79705.
    UCSCiuc002bwq.1. human. [Q38SD2-2]
    uc002bwr.3. human. [Q38SD2-1]

    Polymorphism databases

    DMDMi313104220.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC090907 Genomic DNA. No translation available.
    BC066655 mRNA. Translation: AAH66655.1 .
    BC068080 mRNA. Translation: AAH68080.1 .
    DQ013130 mRNA. Translation: AAY67799.1 . Sequence problems.
    AK026772 mRNA. Translation: BAB15547.1 . Different initiation.
    AK130975 mRNA. Translation: BAC85472.1 . Different initiation.
    AK131075 mRNA. Translation: BAC85125.1 .
    AB058693 mRNA. Translation: BAB47419.1 .
    CCDSi CCDS42086.1. [Q38SD2-1 ]
    RefSeqi NP_078928.3. NM_024652.3. [Q38SD2-1 ]
    UniGenei Hs.407918.

    3D structure databases

    ProteinModelPortali Q38SD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122823. 31 interactions.
    IntActi Q38SD2. 78 interactions.
    STRINGi 9606.ENSP00000373600.

    PTM databases

    PhosphoSitei Q38SD2.

    Polymorphism databases

    DMDMi 313104220.

    Proteomic databases

    MaxQBi Q38SD2.
    PaxDbi Q38SD2.
    PRIDEi Q38SD2.

    Protocols and materials databases

    DNASUi 79705.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388948 ; ENSP00000373600 ; ENSG00000154237 . [Q38SD2-1 ]
    ENST00000532029 ; ENSP00000433268 ; ENSG00000154237 . [Q38SD2-2 ]
    GeneIDi 79705.
    KEGGi hsa:79705.
    UCSCi uc002bwq.1. human. [Q38SD2-2 ]
    uc002bwr.3. human. [Q38SD2-1 ]

    Organism-specific databases

    CTDi 79705.
    GeneCardsi GC15P101459.
    H-InvDB HIX0012627.
    HGNCi HGNC:18608. LRRK1.
    HPAi HPA010537.
    MIMi 610986. gene.
    neXtProti NX_Q38SD2.
    PharmGKBi PA134892363.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOVERGENi HBG081936.
    KOi K08843.
    OMAi FEEENAT.
    OrthoDBi EOG761BST.
    PhylomeDBi Q38SD2.
    TreeFami TF313679.

    Enzyme and pathway databases

    SignaLinki Q38SD2.

    Miscellaneous databases

    GeneWikii LRRK1.
    GenomeRNAii 79705.
    NextBioi 69015.
    PROi Q38SD2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q38SD2.
    Bgeei Q38SD2.
    CleanExi HS_LRRK1.
    Genevestigatori Q38SD2.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR000719. Prot_kinase_dom.
    IPR020859. ROC_GTPase.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF08477. Miro. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    SM00369. LRR_TYP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS51450. LRR. 11 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS51424. ROC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-2015 (ISOFORM 1).
      Tissue: PancreasImported and SkinImported.
    3. "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain."
      Korr D., Toschi L., Donner P., Pohlenz H.-P., Kreft B., Weiss B.
      Cell. Signal. 18:910-920(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-2015 (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, GTP-BINDING, MUTAGENESIS OF LYS-651; LYS-746; PHE-1022; LYS-1270 AND ILE-1412.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-364 AND 905-2015 (ISOFORM 1).
      Tissue: LungImported, MacrophageImported and SpleenImported.
    5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-2015 (ISOFORM 1).
      Tissue: BrainImported.
    6. "Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers."
      Civiero L., Vancraenenbroeck R., Belluzzi E., Beilina A., Lobbestael E., Reyniers L., Gao F., Micetic I., De Maeyer M., Bubacco L., Baekelandt V., Cookson M.R., Greggio E., Taymans J.M.
      PLoS ONE 7:E43472-E43472(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LACK OF AUTOPHOSPHORYLATION.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-1803; PHE-1824; ASN-1847 AND GLY-1927.

    Entry informationi

    Entry nameiLRRK1_HUMAN
    AccessioniPrimary (citable) accession number: Q38SD2
    Secondary accession number(s): Q6NVH5
    , Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3