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Q38SD2

- LRRK1_HUMAN

UniProt

Q38SD2 - LRRK1_HUMAN

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Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

LRRK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Magnesium or manganese.1 Publication

Enzyme regulationi

Binding of GTP stimulates kinase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1270 – 12701ATPPROSITE-ProRule annotation
Active sitei1386 – 13861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1248 – 12569ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. identical protein binding Source: IntAct
  4. metal ion binding Source: UniProtKB-KW
  5. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ38SD2.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 1 (EC:2.7.11.1)
Gene namesi
Name:LRRK1Imported
Synonyms:KIAA1790Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:18608. LRRK1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi651 – 6511K → A: Loss of GTP/GDP-binding. 1 Publication
Mutagenesisi746 – 7461K → G: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication
Mutagenesisi1022 – 10221F → C: No effect on GTP-binding but loss of subsequent stimulation of kinase activity. 1 Publication
Mutagenesisi1270 – 12701K → W: Loss of autophosphorylation. 1 Publication
Mutagenesisi1412 – 14121I → T: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134892363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20152015Leucine-rich repeat serine/threonine-protein kinase 1PRO_0000233377Add
BLAST

Proteomic databases

MaxQBiQ38SD2.
PaxDbiQ38SD2.
PRIDEiQ38SD2.

PTM databases

PhosphoSiteiQ38SD2.

Expressioni

Gene expression databases

BgeeiQ38SD2.
CleanExiHS_LRRK1.
ExpressionAtlasiQ38SD2. baseline and differential.
GenevestigatoriQ38SD2.

Organism-specific databases

HPAiHPA010537.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1050422,EBI-1050422
ABL1P005193EBI-1050422,EBI-375543
BAG5Q9UL153EBI-1050422,EBI-356517
DAPK1P533552EBI-1050422,EBI-358616
EGFRP005332EBI-1050422,EBI-297353
LRRK2Q5S0075EBI-1050422,EBI-5323863

Protein-protein interaction databases

BioGridi122823. 32 interactions.
IntActiQ38SD2. 78 interactions.
STRINGi9606.ENSP00000373600.

Structurei

3D structure databases

ProteinModelPortaliQ38SD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 11631ANK 1Add
BLAST
Repeati119 – 14830ANK 2Add
BLAST
Repeati152 – 18231ANK 3Add
BLAST
Repeati193 – 22230ANK 4Add
BLAST
Repeati279 – 30022LRR 1Add
BLAST
Repeati303 – 32422LRR 2Add
BLAST
Repeati330 – 35122LRR 3Add
BLAST
Repeati353 – 37422LRR 4Add
BLAST
Repeati381 – 40222LRR 5Add
BLAST
Repeati405 – 42622LRR 6Add
BLAST
Repeati427 – 44721LRR 7Add
BLAST
Repeati451 – 47222LRR 8Add
BLAST
Repeati474 – 49522LRR 9Add
BLAST
Repeati498 – 51922LRR 10Add
BLAST
Repeati549 – 57022LRR 11Add
BLAST
Repeati572 – 59423LRR 12Add
BLAST
Repeati596 – 61722LRR 13Add
BLAST
Domaini632 – 826195RocPROSITE-ProRule annotationAdd
BLAST
Domaini1242 – 1525284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Sequence Analysis
Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00530000063477.
HOVERGENiHBG081936.
InParanoidiQ38SD2.
KOiK08843.
OMAiFEEENAT.
OrthoDBiEOG761BST.
PhylomeDBiQ38SD2.
TreeFamiTF313679.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR020859. ROC_GTPase.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM00369. LRR_TYP. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51450. LRR. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q38SD2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGMSQRPPS MYWCVGPEES AVCPERAMET LNGAGDTGGK PSTRGGDPAA
60 70 80 90 100
RSRRTEGIRA AYRRGDRGGA RDLLEEACDQ CASQLEKGQL LSIPAAYGDL
110 120 130 140 150
EMVRYLLSKR LVELPTEPTD DNPAVVAAYF GHTAVVQELL ESLPGPCSPQ
160 170 180 190 200
RLLNWMLALA CQRGHLGVVK LLVLTHGADP ESYAVRKNEF PVIVRLPLYA
210 220 230 240 250
AIKSGNEDIA IFLLRHGAYF CSYILLDSPD PSKHLLRKYF IEASPLPSSY
260 270 280 290 300
PGKTALRVKW SHLRLPWVDL DWLIDISCQI TELDLSANCL ATLPSVIPWG
310 320 330 340 350
LINLRKLNLS DNHLGELPGV QSSDEIICSR LLEIDISSNK LSHLPPGFLH
360 370 380 390 400
LSKLQKLTAS KNCLEKLFEE ENATNWIGLR KLQELDISDN KLTELPALFL
410 420 430 440 450
HSFKSLNSLN VSRNNLKVFP DPWACPLKCC KASRNALECL PDKMAVFWKN
460 470 480 490 500
HLKDVDFSEN ALKEVPLGLF QLDALMFLRL QGNQLAALPP QEKWTCRQLK
510 520 530 540 550
TLDLSRNQLG KNEDGLKTKR IAFFTTRGRQ RSGTEAASVL EFPAFLSESL
560 570 580 590 600
EVLCLNDNHL DTVPPSVCLL KSLSELYLGN NPGLRELPPE LGQLGNLWQL
610 620 630 640 650
DTEDLTISNV PAEIQKEGPK AMLSYLRAQL RKAEKCKLMK MIIVGPPRQG
660 670 680 690 700
KSTLLEILQT GRAPQVVHGE ATIRTTKWEL QRPAGSRAKV ESVEFNVWDI
710 720 730 740 750
GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA
760 770 780 790 800
VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH
810 820 830 840 850
LHEISCKSLE GQEGLRQLIF HVTCSMKDVG STIGCQRLAG RLIPRSYLSL
860 870 880 890 900
QEAVLAEQQR RSRDDDVQYL TDRQLEQLVE QTPDNDIKDY EDLQSAISFL
910 920 930 940 950
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIR
960 970 980 990 1000
AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG
1010 1020 1030 1040 1050
LDTHGMRHPT ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK
1060 1070 1080 1090 1100
KNTKSRNRKV TIYSFTGNQR NRCSTFRVKR NQTIYWQEGL LVTFDGGYLS
1110 1120 1130 1140 1150
VESSDVNWKK KKSGGMKIVC QSEVRDFSAM AFITDHVNSL IDQWFPALTA
1160 1170 1180 1190 1200
TESDGTPLME QYVPCPVCET AWAQHTDPSE KSEDVQYFDM EDCVLTAIER
1210 1220 1230 1240 1250
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH SEDEGSVLGQ
1260 1270 1280 1290 1300
GGSGTVIYRA RYQGQPVAVK RFHIKKFKNF ANVPADTMLR HLRATDAMKN
1310 1320 1330 1340 1350
FSEFRQEASM LHALQHPCIV ALIGISIHPL CFALELAPLS SLNTVLSENA
1360 1370 1380 1390 1400
RDSSFIPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLDVK
1410 1420 1430 1440 1450
EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY
1460 1470 1480 1490 1500
GMVLYELLSG QRPALGHHQL QIAKKLSKGI RPVLGQPEEV QFRRLQALMM
1510 1520 1530 1540 1550
ECWDTKPEKR PLALSVVSQM KDPTFATFMY ELCCGKQTAF FSSQGQEYTV
1560 1570 1580 1590 1600
VFWDGKEESR NYTVVNTEKG LMEVQRMCCP GMKVSCQLQV QRSLWTATED
1610 1620 1630 1640 1650
QKIYIYTLKG MCPLNTPQQA LDTPAVVTCF LAVPVIKKNS YLVLAGLADG
1660 1670 1680 1690 1700
LVAVFPVVRG TPKDSCSYLC SHTANRSKFS IADEDARQNP YPVKAMEVVN
1710 1720 1730 1740 1750
SGSEVWYSNG PGLLVIDCAS LEICRRLEPY MAPSMVTSVV CSSEGRGEEV
1760 1770 1780 1790 1800
VWCLDDKANS LVMYHSTTYQ LCARYFCGVP SPLRDMFPVR PLDTEPPAAS
1810 1820 1830 1840 1850
HTANPKVPEG DSIADVSIMY SEELGTQILI HQESLTDYCS MSSYSSSPPR
1860 1870 1880 1890 1900
QAARSPSSLP SSPASSSSVP FSTDCEDSDM LHTPGAASDR SEHDLTPMDG
1910 1920 1930 1940 1950
ETFSQHLQAV KILAVRDLIW VPRRGGDVIV IGLEKDSGAQ RGRVIAVLKA
1960 1970 1980 1990 2000
RELTPHGVLV DAAVVAKDTV VCTFENENTE WCLAVWRGWG AREFDIFYQS
2010
YEELGRLEAC TRKRR

Note: No experimental confirmation available.Curated

Length:2,015
Mass (Da):225,393
Last modified:November 30, 2010 - v3
Checksum:i38E77EDC7C84583B
GO
Isoform 21 Publication (identifier: Q38SD2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-264: ALRVKWSHLR → VSSHCLWSVF
     265-2015: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:264
Mass (Da):28,848
Checksum:i8E95B1F50F1DB2E4
GO

Sequence cautioni

The sequence AAY67799.1 differs from that shown. Reason: The cDNA contains a duplication of exon 3.
The sequence BAB15547.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC85472.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031K → R in BAC85472. (PubMed:14702039)Curated
Sequence conflicti1938 – 19381G → E in AAH66655. (PubMed:15489334)Curated
Sequence conflicti1938 – 19381G → E in BAB47419. (PubMed:11347906)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1803 – 18031A → T.1 Publication
VAR_040674
Natural varianti1824 – 18241L → F.1 Publication
VAR_040675
Natural varianti1847 – 18471S → N.1 Publication
VAR_040676
Natural varianti1927 – 19271D → G.1 Publication
VAR_040677

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei255 – 26410ALRVKWSHLR → VSSHCLWSVF in isoform 2. 1 PublicationVSP_040119
Alternative sequencei265 – 20151751Missing in isoform 2. 1 PublicationVSP_040120Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090907 Genomic DNA. No translation available.
BC066655 mRNA. Translation: AAH66655.1.
BC068080 mRNA. Translation: AAH68080.1.
DQ013130 mRNA. Translation: AAY67799.1. Sequence problems.
AK026772 mRNA. Translation: BAB15547.1. Different initiation.
AK130975 mRNA. Translation: BAC85472.1. Different initiation.
AK131075 mRNA. Translation: BAC85125.1.
AB058693 mRNA. Translation: BAB47419.1.
CCDSiCCDS42086.1. [Q38SD2-1]
RefSeqiNP_078928.3. NM_024652.3. [Q38SD2-1]
UniGeneiHs.407918.

Genome annotation databases

EnsembliENST00000388948; ENSP00000373600; ENSG00000154237. [Q38SD2-1]
ENST00000532029; ENSP00000433268; ENSG00000154237. [Q38SD2-2]
GeneIDi79705.
KEGGihsa:79705.
UCSCiuc002bwq.1. human. [Q38SD2-2]
uc002bwr.3. human. [Q38SD2-1]

Polymorphism databases

DMDMi313104220.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090907 Genomic DNA. No translation available.
BC066655 mRNA. Translation: AAH66655.1 .
BC068080 mRNA. Translation: AAH68080.1 .
DQ013130 mRNA. Translation: AAY67799.1 . Sequence problems.
AK026772 mRNA. Translation: BAB15547.1 . Different initiation.
AK130975 mRNA. Translation: BAC85472.1 . Different initiation.
AK131075 mRNA. Translation: BAC85125.1 .
AB058693 mRNA. Translation: BAB47419.1 .
CCDSi CCDS42086.1. [Q38SD2-1 ]
RefSeqi NP_078928.3. NM_024652.3. [Q38SD2-1 ]
UniGenei Hs.407918.

3D structure databases

ProteinModelPortali Q38SD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122823. 32 interactions.
IntActi Q38SD2. 78 interactions.
STRINGi 9606.ENSP00000373600.

PTM databases

PhosphoSitei Q38SD2.

Polymorphism databases

DMDMi 313104220.

Proteomic databases

MaxQBi Q38SD2.
PaxDbi Q38SD2.
PRIDEi Q38SD2.

Protocols and materials databases

DNASUi 79705.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388948 ; ENSP00000373600 ; ENSG00000154237 . [Q38SD2-1 ]
ENST00000532029 ; ENSP00000433268 ; ENSG00000154237 . [Q38SD2-2 ]
GeneIDi 79705.
KEGGi hsa:79705.
UCSCi uc002bwq.1. human. [Q38SD2-2 ]
uc002bwr.3. human. [Q38SD2-1 ]

Organism-specific databases

CTDi 79705.
GeneCardsi GC15P101459.
H-InvDB HIX0012627.
HGNCi HGNC:18608. LRRK1.
HPAi HPA010537.
MIMi 610986. gene.
neXtProti NX_Q38SD2.
PharmGKBi PA134892363.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00530000063477.
HOVERGENi HBG081936.
InParanoidi Q38SD2.
KOi K08843.
OMAi FEEENAT.
OrthoDBi EOG761BST.
PhylomeDBi Q38SD2.
TreeFami TF313679.

Enzyme and pathway databases

SignaLinki Q38SD2.

Miscellaneous databases

GeneWikii LRRK1.
GenomeRNAii 79705.
NextBioi 69015.
PROi Q38SD2.
SOURCEi Search...

Gene expression databases

Bgeei Q38SD2.
CleanExi HS_LRRK1.
ExpressionAtlasi Q38SD2. baseline and differential.
Genevestigatori Q38SD2.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR020859. ROC_GTPase.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
SM00369. LRR_TYP. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS51450. LRR. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-2015 (ISOFORM 1).
    Tissue: PancreasImported and SkinImported.
  3. "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain."
    Korr D., Toschi L., Donner P., Pohlenz H.-P., Kreft B., Weiss B.
    Cell. Signal. 18:910-920(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-2015 (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, GTP-BINDING, MUTAGENESIS OF LYS-651; LYS-746; PHE-1022; LYS-1270 AND ILE-1412.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-364 AND 905-2015 (ISOFORM 1).
    Tissue: LungImported, MacrophageImported and SpleenImported.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-2015 (ISOFORM 1).
    Tissue: BrainImported.
  6. "Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers."
    Civiero L., Vancraenenbroeck R., Belluzzi E., Beilina A., Lobbestael E., Reyniers L., Gao F., Micetic I., De Maeyer M., Bubacco L., Baekelandt V., Cookson M.R., Greggio E., Taymans J.M.
    PLoS ONE 7:E43472-E43472(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LACK OF AUTOPHOSPHORYLATION.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-1803; PHE-1824; ASN-1847 AND GLY-1927.

Entry informationi

Entry nameiLRRK1_HUMAN
AccessioniPrimary (citable) accession number: Q38SD2
Secondary accession number(s): Q6NVH5
, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3