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Protein
Submitted name:

C-C chemokine receptor type 5

Gene

CCR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
C-C chemokine receptor type 5Imported
Submitted name:
C-C motif chemokine receptor 5 A159A variantImported
Submitted name:
C-C motif chemokine receptor 5 I124I variantImported
Submitted name:
C-C motif chemokine receptor 5 I237I variantImported
Submitted name:
CC chemokine receptor 5Imported
Submitted name:
Chemokine (C-C motif) receptor 5, isoform CRA_aImported
Submitted name:
cDNA FLJ78003, highly similar to Homo sapiens chemokine (C-C motif) receptor 5, mRNAImported
Gene namesi
Name:CCR5Imported
ORF Names:hCG_15321Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000160791.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei68 – 87HelicalSequence analysisAdd BLAST20
Transmembranei107 – 129HelicalSequence analysisAdd BLAST23
Transmembranei141 – 166HelicalSequence analysisAdd BLAST26
Transmembranei198 – 221HelicalSequence analysisAdd BLAST24
Transmembranei233 – 251HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26170

Expressioni

Gene expression databases

BgeeiENSG00000160791
ExpressionAtlasiQ38L21 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ38L21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 297G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG106917
KOiK04180
OMAiFGNTMCQ
OrthoDBiEOG091G0B7A

Family and domain databases

InterProiView protein in InterPro
IPR002240 Chemokine_CCR5
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01110 CHEMOKINER5
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q38L21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML
60 70 80 90 100
VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI
210 220 230 240 250
LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP
260 270 280 290 300
YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV
310 320 330 340 350
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV

GL
Length:352
Mass (Da):40,524
Last modified:November 22, 2005 - v1
Checksum:i88ECE1F38E6D45A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ217934 Genomic DNA Translation: ABB01004.1
EF408698 Genomic DNA Translation: ABQ95606.1
EF408699 Genomic DNA Translation: ABQ95607.1
EF408700 Genomic DNA Translation: ABQ95608.1
GQ917109 Genomic DNA Translation: ACX50405.1
JQ291182 Genomic DNA Translation: AEZ06624.1
JQ291183 Genomic DNA Translation: AEZ06625.1
JQ291184 Genomic DNA Translation: AEZ06626.1
JQ291185 Genomic DNA Translation: AEZ06627.1
JQ291186 Genomic DNA Translation: AEZ06628.1
JQ291187 Genomic DNA Translation: AEZ06629.1
JQ291188 Genomic DNA Translation: AEZ06630.1
JQ291190 Genomic DNA Translation: AEZ06632.1
JQ291191 Genomic DNA Translation: AEZ06633.1
JQ291192 Genomic DNA Translation: AEZ06634.1
JQ291193 Genomic DNA Translation: AEZ06635.1
JQ291194 Genomic DNA Translation: AEZ06636.1
JQ291195 Genomic DNA Translation: AEZ06637.1
JQ291196 Genomic DNA Translation: AEZ06638.1
JQ291197 Genomic DNA Translation: AEZ06639.1
JQ291198 Genomic DNA Translation: AEZ06640.1
JQ291199 Genomic DNA Translation: AEZ06641.1
JQ291200 Genomic DNA Translation: AEZ06642.1
JQ291201 Genomic DNA Translation: AEZ06643.1
JQ291202 Genomic DNA Translation: AEZ06644.1
JQ291203 Genomic DNA Translation: AEZ06645.1
JQ291204 Genomic DNA Translation: AEZ06646.1
JQ291205 Genomic DNA Translation: AEZ06647.1
JQ291206 Genomic DNA Translation: AEZ06648.1
JQ291207 Genomic DNA Translation: AEZ06649.1
JQ291208 Genomic DNA Translation: AEZ06650.1
JQ291209 Genomic DNA Translation: AEZ06651.1
JQ291210 Genomic DNA Translation: AEZ06652.1
JQ291211 Genomic DNA Translation: AEZ06653.1
JQ291212 Genomic DNA Translation: AEZ06654.1
JQ291213 Genomic DNA Translation: AEZ06655.1
JQ291214 Genomic DNA Translation: AEZ06656.1
JQ291215 Genomic DNA Translation: AEZ06657.1
JQ291216 Genomic DNA Translation: AEZ06658.1
JQ291217 Genomic DNA Translation: AEZ06659.1
JQ291218 Genomic DNA Translation: AEZ06660.1
JQ291219 Genomic DNA Translation: AEZ06661.1
JQ291220 Genomic DNA Translation: AEZ06662.1
JQ291221 Genomic DNA Translation: AEZ06663.1
JQ291222 Genomic DNA Translation: AEZ06664.1
JQ291223 Genomic DNA Translation: AEZ06665.1
JQ291224 Genomic DNA Translation: AEZ06666.1
KC248080 Genomic DNA Translation: AGC13086.1
KC248081 Genomic DNA Translation: AGC13087.1
KC248082 Genomic DNA Translation: AGC13088.1
KC248083 Genomic DNA Translation: AGC13089.1
KC248084 Genomic DNA Translation: AGC13090.1
KC248085 Genomic DNA Translation: AGC13091.1
KC248086 Genomic DNA Translation: AGC13092.1
KC248087 Genomic DNA Translation: AGC13093.1
KC248089 Genomic DNA Translation: AGC13095.1
KM355847 Genomic DNA Translation: AIP93477.1
KM355849 Genomic DNA Translation: AIP93479.1
KM355851 Genomic DNA Translation: AIP93481.1
KM355854 Genomic DNA Translation: AIP93484.1
KM355855 Genomic DNA Translation: AIP93485.1
KM355858 Genomic DNA Translation: AIP93488.1
KM355868 Genomic DNA Translation: AIP93498.1
KM355871 Genomic DNA Translation: AIP93501.1
KM355872 Genomic DNA Translation: AIP93502.1
KM355873 Genomic DNA Translation: AIP93503.1
KM355874 Genomic DNA Translation: AIP93504.1
KM355876 Genomic DNA Translation: AIP93506.1
KM355877 Genomic DNA Translation: AIP93507.1
KM355878 Genomic DNA Translation: AIP93508.1
KM355880 Genomic DNA Translation: AIP93510.1
KM355881 Genomic DNA Translation: AIP93511.1
KM355882 Genomic DNA Translation: AIP93512.1
KM355883 Genomic DNA Translation: AIP93513.1
KM355892 Genomic DNA Translation: AIP93519.1
KM355916 Genomic DNA Translation: AIP93534.1
KM355921 Genomic DNA Translation: AIP93539.1
KM355927 Genomic DNA Translation: AIP93543.1
KM355943 Genomic DNA Translation: AIP93555.1
AK292132 mRNA Translation: BAF84821.1
CH471055 Genomic DNA Translation: EAW64763.1
RefSeqiNP_000570.1, NM_000579.3
NP_001093638.1, NM_001100168.1
UniGeneiHs.450802

Genome annotation databases

GeneIDi1234
KEGGihsa:1234
UCSCiuc062izs.1 human

Similar proteinsi

Entry informationi

Entry nameiQ38L21_HUMAN
AccessioniPrimary (citable) accession number: Q38L21
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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