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Protein
Submitted name:

C-C chemokine receptor type 5

Gene

CCR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
C-C chemokine receptor type 5Imported
Submitted name:
C-C motif chemokine receptor 5 A159A variantImported
Submitted name:
C-C motif chemokine receptor 5 I124I variantImported
Submitted name:
C-C motif chemokine receptor 5 I237I variantImported
Submitted name:
CC chemokine receptor 5Imported
Submitted name:
Chemokine (C-C motif) receptor 5, isoform CRA_aImported
Submitted name:
cDNA FLJ78003, highly similar to Homo sapiens chemokine (C-C motif) receptor 5, mRNAImported
Gene namesi
Name:CCR5Imported
ORF Names:hCG_15321Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei68 – 8720HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12923HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16626HelicalSequence analysisAdd
BLAST
Transmembranei198 – 22124HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25119HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26170.

Expressioni

Gene expression databases

BgeeiENSG00000160791.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292303.

Structurei

3D structure databases

SMRiQ38L21. Positions 19-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 297251G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106917.
KOiK04180.
OMAiGNTMCQL.
OrthoDBiEOG091G0B7A.
PhylomeDBiQ38L21.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38L21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML
60 70 80 90 100
VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI
210 220 230 240 250
LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP
260 270 280 290 300
YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV
310 320 330 340 350
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV

GL
Length:352
Mass (Da):40,524
Last modified:November 22, 2005 - v1
Checksum:i88ECE1F38E6D45A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ217934 Genomic DNA. Translation: ABB01004.1.
EF408698 Genomic DNA. Translation: ABQ95606.1.
EF408699 Genomic DNA. Translation: ABQ95607.1.
EF408700 Genomic DNA. Translation: ABQ95608.1.
GQ917109 Genomic DNA. Translation: ACX50405.1.
JQ291182 Genomic DNA. Translation: AEZ06624.1.
JQ291183 Genomic DNA. Translation: AEZ06625.1.
JQ291184 Genomic DNA. Translation: AEZ06626.1.
JQ291185 Genomic DNA. Translation: AEZ06627.1.
JQ291186 Genomic DNA. Translation: AEZ06628.1.
JQ291187 Genomic DNA. Translation: AEZ06629.1.
JQ291188 Genomic DNA. Translation: AEZ06630.1.
JQ291190 Genomic DNA. Translation: AEZ06632.1.
JQ291191 Genomic DNA. Translation: AEZ06633.1.
JQ291192 Genomic DNA. Translation: AEZ06634.1.
JQ291193 Genomic DNA. Translation: AEZ06635.1.
JQ291194 Genomic DNA. Translation: AEZ06636.1.
JQ291195 Genomic DNA. Translation: AEZ06637.1.
JQ291196 Genomic DNA. Translation: AEZ06638.1.
JQ291197 Genomic DNA. Translation: AEZ06639.1.
JQ291198 Genomic DNA. Translation: AEZ06640.1.
JQ291199 Genomic DNA. Translation: AEZ06641.1.
JQ291200 Genomic DNA. Translation: AEZ06642.1.
JQ291201 Genomic DNA. Translation: AEZ06643.1.
JQ291202 Genomic DNA. Translation: AEZ06644.1.
JQ291203 Genomic DNA. Translation: AEZ06645.1.
JQ291204 Genomic DNA. Translation: AEZ06646.1.
JQ291205 Genomic DNA. Translation: AEZ06647.1.
JQ291206 Genomic DNA. Translation: AEZ06648.1.
JQ291207 Genomic DNA. Translation: AEZ06649.1.
JQ291208 Genomic DNA. Translation: AEZ06650.1.
JQ291209 Genomic DNA. Translation: AEZ06651.1.
JQ291210 Genomic DNA. Translation: AEZ06652.1.
JQ291211 Genomic DNA. Translation: AEZ06653.1.
JQ291212 Genomic DNA. Translation: AEZ06654.1.
JQ291213 Genomic DNA. Translation: AEZ06655.1.
JQ291214 Genomic DNA. Translation: AEZ06656.1.
JQ291215 Genomic DNA. Translation: AEZ06657.1.
JQ291216 Genomic DNA. Translation: AEZ06658.1.
JQ291217 Genomic DNA. Translation: AEZ06659.1.
JQ291218 Genomic DNA. Translation: AEZ06660.1.
JQ291219 Genomic DNA. Translation: AEZ06661.1.
JQ291220 Genomic DNA. Translation: AEZ06662.1.
JQ291221 Genomic DNA. Translation: AEZ06663.1.
JQ291222 Genomic DNA. Translation: AEZ06664.1.
JQ291223 Genomic DNA. Translation: AEZ06665.1.
JQ291224 Genomic DNA. Translation: AEZ06666.1.
KC248080 Genomic DNA. Translation: AGC13086.1.
KC248081 Genomic DNA. Translation: AGC13087.1.
KC248082 Genomic DNA. Translation: AGC13088.1.
KC248083 Genomic DNA. Translation: AGC13089.1.
KC248084 Genomic DNA. Translation: AGC13090.1.
KC248085 Genomic DNA. Translation: AGC13091.1.
KC248086 Genomic DNA. Translation: AGC13092.1.
KC248087 Genomic DNA. Translation: AGC13093.1.
KC248089 Genomic DNA. Translation: AGC13095.1.
KM355847 Genomic DNA. Translation: AIP93477.1.
KM355849 Genomic DNA. Translation: AIP93479.1.
KM355851 Genomic DNA. Translation: AIP93481.1.
KM355854 Genomic DNA. Translation: AIP93484.1.
KM355855 Genomic DNA. Translation: AIP93485.1.
KM355858 Genomic DNA. Translation: AIP93488.1.
KM355868 Genomic DNA. Translation: AIP93498.1.
KM355871 Genomic DNA. Translation: AIP93501.1.
KM355872 Genomic DNA. Translation: AIP93502.1.
KM355873 Genomic DNA. Translation: AIP93503.1.
KM355874 Genomic DNA. Translation: AIP93504.1.
KM355876 Genomic DNA. Translation: AIP93506.1.
KM355877 Genomic DNA. Translation: AIP93507.1.
KM355878 Genomic DNA. Translation: AIP93508.1.
KM355880 Genomic DNA. Translation: AIP93510.1.
KM355881 Genomic DNA. Translation: AIP93511.1.
KM355882 Genomic DNA. Translation: AIP93512.1.
KM355883 Genomic DNA. Translation: AIP93513.1.
KM355892 Genomic DNA. Translation: AIP93519.1.
KM355916 Genomic DNA. Translation: AIP93534.1.
KM355921 Genomic DNA. Translation: AIP93539.1.
KM355927 Genomic DNA. Translation: AIP93543.1.
KM355943 Genomic DNA. Translation: AIP93555.1.
AK292132 mRNA. Translation: BAF84821.1.
CH471055 Genomic DNA. Translation: EAW64763.1.
RefSeqiNP_000570.1. NM_000579.3.
NP_001093638.1. NM_001100168.1.
UniGeneiHs.450802.

Genome annotation databases

GeneIDi1234.
KEGGihsa:1234.
UCSCiuc062izs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ217934 Genomic DNA. Translation: ABB01004.1.
EF408698 Genomic DNA. Translation: ABQ95606.1.
EF408699 Genomic DNA. Translation: ABQ95607.1.
EF408700 Genomic DNA. Translation: ABQ95608.1.
GQ917109 Genomic DNA. Translation: ACX50405.1.
JQ291182 Genomic DNA. Translation: AEZ06624.1.
JQ291183 Genomic DNA. Translation: AEZ06625.1.
JQ291184 Genomic DNA. Translation: AEZ06626.1.
JQ291185 Genomic DNA. Translation: AEZ06627.1.
JQ291186 Genomic DNA. Translation: AEZ06628.1.
JQ291187 Genomic DNA. Translation: AEZ06629.1.
JQ291188 Genomic DNA. Translation: AEZ06630.1.
JQ291190 Genomic DNA. Translation: AEZ06632.1.
JQ291191 Genomic DNA. Translation: AEZ06633.1.
JQ291192 Genomic DNA. Translation: AEZ06634.1.
JQ291193 Genomic DNA. Translation: AEZ06635.1.
JQ291194 Genomic DNA. Translation: AEZ06636.1.
JQ291195 Genomic DNA. Translation: AEZ06637.1.
JQ291196 Genomic DNA. Translation: AEZ06638.1.
JQ291197 Genomic DNA. Translation: AEZ06639.1.
JQ291198 Genomic DNA. Translation: AEZ06640.1.
JQ291199 Genomic DNA. Translation: AEZ06641.1.
JQ291200 Genomic DNA. Translation: AEZ06642.1.
JQ291201 Genomic DNA. Translation: AEZ06643.1.
JQ291202 Genomic DNA. Translation: AEZ06644.1.
JQ291203 Genomic DNA. Translation: AEZ06645.1.
JQ291204 Genomic DNA. Translation: AEZ06646.1.
JQ291205 Genomic DNA. Translation: AEZ06647.1.
JQ291206 Genomic DNA. Translation: AEZ06648.1.
JQ291207 Genomic DNA. Translation: AEZ06649.1.
JQ291208 Genomic DNA. Translation: AEZ06650.1.
JQ291209 Genomic DNA. Translation: AEZ06651.1.
JQ291210 Genomic DNA. Translation: AEZ06652.1.
JQ291211 Genomic DNA. Translation: AEZ06653.1.
JQ291212 Genomic DNA. Translation: AEZ06654.1.
JQ291213 Genomic DNA. Translation: AEZ06655.1.
JQ291214 Genomic DNA. Translation: AEZ06656.1.
JQ291215 Genomic DNA. Translation: AEZ06657.1.
JQ291216 Genomic DNA. Translation: AEZ06658.1.
JQ291217 Genomic DNA. Translation: AEZ06659.1.
JQ291218 Genomic DNA. Translation: AEZ06660.1.
JQ291219 Genomic DNA. Translation: AEZ06661.1.
JQ291220 Genomic DNA. Translation: AEZ06662.1.
JQ291221 Genomic DNA. Translation: AEZ06663.1.
JQ291222 Genomic DNA. Translation: AEZ06664.1.
JQ291223 Genomic DNA. Translation: AEZ06665.1.
JQ291224 Genomic DNA. Translation: AEZ06666.1.
KC248080 Genomic DNA. Translation: AGC13086.1.
KC248081 Genomic DNA. Translation: AGC13087.1.
KC248082 Genomic DNA. Translation: AGC13088.1.
KC248083 Genomic DNA. Translation: AGC13089.1.
KC248084 Genomic DNA. Translation: AGC13090.1.
KC248085 Genomic DNA. Translation: AGC13091.1.
KC248086 Genomic DNA. Translation: AGC13092.1.
KC248087 Genomic DNA. Translation: AGC13093.1.
KC248089 Genomic DNA. Translation: AGC13095.1.
KM355847 Genomic DNA. Translation: AIP93477.1.
KM355849 Genomic DNA. Translation: AIP93479.1.
KM355851 Genomic DNA. Translation: AIP93481.1.
KM355854 Genomic DNA. Translation: AIP93484.1.
KM355855 Genomic DNA. Translation: AIP93485.1.
KM355858 Genomic DNA. Translation: AIP93488.1.
KM355868 Genomic DNA. Translation: AIP93498.1.
KM355871 Genomic DNA. Translation: AIP93501.1.
KM355872 Genomic DNA. Translation: AIP93502.1.
KM355873 Genomic DNA. Translation: AIP93503.1.
KM355874 Genomic DNA. Translation: AIP93504.1.
KM355876 Genomic DNA. Translation: AIP93506.1.
KM355877 Genomic DNA. Translation: AIP93507.1.
KM355878 Genomic DNA. Translation: AIP93508.1.
KM355880 Genomic DNA. Translation: AIP93510.1.
KM355881 Genomic DNA. Translation: AIP93511.1.
KM355882 Genomic DNA. Translation: AIP93512.1.
KM355883 Genomic DNA. Translation: AIP93513.1.
KM355892 Genomic DNA. Translation: AIP93519.1.
KM355916 Genomic DNA. Translation: AIP93534.1.
KM355921 Genomic DNA. Translation: AIP93539.1.
KM355927 Genomic DNA. Translation: AIP93543.1.
KM355943 Genomic DNA. Translation: AIP93555.1.
AK292132 mRNA. Translation: BAF84821.1.
CH471055 Genomic DNA. Translation: EAW64763.1.
RefSeqiNP_000570.1. NM_000579.3.
NP_001093638.1. NM_001100168.1.
UniGeneiHs.450802.

3D structure databases

SMRiQ38L21. Positions 19-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292303.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1234.
KEGGihsa:1234.
UCSCiuc062izs.1. human.

Organism-specific databases

CTDi1234.
PharmGKBiPA26170.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106917.
KOiK04180.
OMAiGNTMCQL.
OrthoDBiEOG091G0B7A.
PhylomeDBiQ38L21.

Miscellaneous databases

GenomeRNAii1234.

Gene expression databases

BgeeiENSG00000160791.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ38L21_HUMAN
AccessioniPrimary (citable) accession number: Q38L21
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.