Q38G75 (Q38G75_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
UDP galactose 4'-epimerase EMBL ABB04110.1
EC=5.1.3.2 EMBL ABB04110.1

Submitted name:
cDNA, FLJ95174, highly similar to Homo sapiens galactose-4-epimerase, UDP- (GALE), mRNA EMBL BAG37021.1

Gene names

Name:

GALE EMBL ABB04110.1

Organism

Homo sapiens (Human) EMBL ABB04110.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the sugar epimerase family. RuleBase RU003508

Ontologies

Keywords
Ligand	NAD RuleBase RU003508
Molecular function	Isomerase RuleBase RU004472 EMBL ABB04110.1
Gene Ontology (GO)
Molecular function	UDP-glucose 4-epimerase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q38G75 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 06FDBF9B1943DF49	FASTA	348	38,282
	10 20 30 40 50 60 MAEKVLVTGG AGYIGSHTVL ELLEAGYLPV VIDNFHNAFR GGGSLPESLR RVQELTGRSV 70 80 90 100 110 120 EFEEMDILDQ GALQRLFKKY SFMAVIHFAG LKAVGESVQK PLDYYRVNLT GTIQLLEIMK 130 140 150 160 170 180 AHGVKNLVFS SSATVYGNPQ YLPLDEAHPT GGCTNPYGKS KFFIEEMIRD LCQADKTWNA 190 200 210 220 230 240 VLLRYFNPTG AHASGCIGED PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD 250 260 270 280 290 300 YIHVVDLAKG HIAALRKLKE QCGCRIYNLG TGTGYSVLQM VQAMEKASGK KIPYKVVARR 310 320 330 340 EGDVAACYAN PSLAQEELGW TAALGLDRMC EDLWRWQKQN PSGFGTQA

References

[1]	"Epimerase-deficiency galactosemia is not a binary condition." Openo K.K., Schulz J.M., Vargas C.A., Orton C.S., Epstein M.P., Schnur R.E., Scaglia F., Berry G.T., Gottesman G.S., Ficicioglu C., Slonim A.E., Schroer R.J., Yu C., Rangel V.E., Keenan J., Lamance K., Fridovich-Keil J.L. Am. J. Hum. Genet. 78:89-102(2006) [PubMed: 16385452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Characterization of two mutations associated with epimerase-deficiency galactosemia, by use of a yeast expression system for human UDP-galactose-4-epimerase." Quimby B.B., Alano A., Almashanu S., Desandro A.M., Cowan T.M., Fridovich-Keil J.L. Am. J. Hum. Genet. 61:590-598(1997) [PubMed: 9326324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Colon EMBL BAG37021.1.
[4]	Openo K., Vargas C., Orton C., Fridovich-Keil J.L. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Openo K., Vargas C., Quimby B., Fridovich-Keil J.L. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ233667 Genomic DNA. Translation: ABB04109.1. DQ233668 mRNA. Translation: ABB04110.1. AK314397 mRNA. Translation: BAG37021.1.
IPI	IPI00553131.
RefSeq	NP_000394.2. NM_000403.3. NP_001008217.1. NM_001008216.1. NP_001121093.1. NM_001127621.1.
UniGene	Hs.632380.
3D structure databases
ProteinModelPortal	Q38G75.
SMR	Q38G75. Positions 1-346.
ModBase	Search...
Protein-protein interaction databases
STRING	Q38G75.
Proteomic databases
PRIDE	Q38G75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2582.
KEGG	hsa:2582.
NMPDR	fig|9606.3.peg.535.
UCSC	uc001bhz.1. human.
Organism-specific databases
CTD	2582.
Phylogenomic databases
HOVERGEN	HBG001396.
OMA	TGRSVEF.
PhylomeDB	Q38G75.
Gene expression databases
ArrayExpress	Q38G75.
Bgee	Q38G75.
Family and domain databases
InterPro	IPR001509. Epimerase_deHydtase. IPR005886. GalE. IPR016040. NAD(P)-bd_dom. IPR008089. Nuc_sugar_epim. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01784.
PANTHER	PTHR10366:SF39. GalE. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
PRINTS	PR01713. NUCEPIMERASE.
TIGRFAMs	TIGR01179. GalE. 1 hit.
ProtoNet	Search...
Other
NextBio	10213.

Entry information

Entry name

Q38G75_HUMAN

Accession

Primary (citable) accession number: Q38G75

Entry history

Integrated into UniProtKB/TrEMBL:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.