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Q38EJ2 (Q38EJ2_TRYB2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=4.3.2.2 EMBL EAN76778.1
Gene names
ORF Names:Tb09.160.5560 EMBL EAN76778.1
OrganismTrypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]
Taxonomic identifier999953 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding29 – 302AMP PDB 4EFC
Nucleotide binding106 – 1083AMP PDB 4EFC

Sites

Metal binding2851Magnesium PDB 4EFC
Metal binding2891Magnesium PDB 4EFC
Metal binding3461Magnesium; via carbonyl oxygen PDB 4EFC
Metal binding3481Magnesium; via carbonyl oxygen PDB 4EFC
Binding site1851AMP PDB 4EFC
Binding site2621AMP PDB 4EFC
Binding site3241AMP PDB 4EFC
Binding site3501AMP PDB 4EFC
Binding site3551AMP PDB 4EFC
Binding site3591AMP PDB 4EFC

Sequences

Sequence LengthMass (Da)Tools
Q38EJ2 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: B3B15E435CF9DE3E

FASTA47153,120
        10         20         30         40         50         60 
MEKGSPSDLN GVDYSVDNPL FALSPLDGRY KRQTKALRAF FSEYGFFRYR VLVEVEYFTA 

        70         80         90        100        110        120 
LCKDVPTIVP LRSVTDEQLQ KLRKITLDCF SVSSAEEIKR LERVTNHDIK AVEYFIKERM 

       130        140        150        160        170        180 
DTCGLSHVTE FVHFGLTSQD INNTAIPMMI RDAIVTLYLP ALDGIIGSLT SKLVDWDVPM 

       190        200        210        220        230        240 
LARTHGQPAS PTNLAKEFVV WIERLREQRR QLCEVPTTGK FGGATGNFNA HLVAYPSVNW 

       250        260        270        280        290        300 
RAFADMFLAK YLGLKRQQAT TQIENYDHLA ALCDACARLH VILIDMCRDV WQYISMGFFK 

       310        320        330        340        350        360 
QKVKEGEVGS STMPHKVNPI DFENAEGNLA LSNALLNFFA SKLPISRLQR DLTDSTVLRN 

       370        380        390        400        410        420 
LGVPIGHACV AFASISQGLE KLMISRETIS RELSSNWAVV AEGIQTVLRR ECYPKPYETL 

       430        440        450        460        470 
KKLTQGNTDV TEEQVRNFIN GLTDISDDVR AELLAITPFT YVGYVPRFSA K 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the African trypanosome Trypanosoma brucei."
Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. expand/collapse author list , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 927/4 GUTat10.1 EMBL EAN76778.1.
[2]"Crystal Structure of Adenylosuccinate Lyase from Trypanosoma Brucei, Tb427tmp.160.5560."
Wernimont A.K., Loppnau P., Osman K.T., Arrowsmith C.H., Edwards A.M., Bountra C., Robinson D.A., Wyatt P.G., Gilbert I.H., Hui R., Lin Y.H.
Submitted (MAR-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH AMP AND MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000207 Genomic DNA. Translation: EAN76778.1.
RefSeqXP_827108.1. XM_822015.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4EFCX-ray2.00A/B1-471[»]
ProteinModelPortalQ38EJ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5691.Tb09.160.5560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAN76778; EAN76778; Tb09.160.5560.
GeneID3660448.
KEGGtbr:Tb09.160.5560.

Phylogenomic databases

eggNOGCOG0015.
HOGENOMHOG000252916.
KOK01756.
OMAPANYIGN.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
InterProIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERPTHR11444. PTHR11444. 1 hit.
PfamPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00149. FUMRATELYASE.
SUPFAMSSF48557. SSF48557. 1 hit.
TIGRFAMsTIGR00928. purB. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ38EJ2_TRYB2
AccessionPrimary (citable) accession number: Q38EJ2
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)