ID   Q38CY8_TRYB2            Unreviewed;       308 AA.
AC   Q38CY8;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=60S ribosomal protein L5, putative {ECO:0000313|EMBL:EAN77332.1};
GN   ORFNames=Tb09.244.2730 {ECO:0000313|EMBL:EAN77332.1}, Tb09.244.2740
GN   {ECO:0000313|EMBL:EAN77331.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN77332.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77332.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:EAN77332.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77332.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [3] {ECO:0007829|PDB:4V8M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX   PubMed=23395961; DOI=10.1038/nature11872;
RA   Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA   Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA   Madison-Antenucci S., Frank J.;
RT   "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT   brucei ribosome.";
RL   Nature 494:385-389(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC       {ECO:0000256|ARBA:ARBA00007116}.
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DR   EMBL; CM000207; EAN77331.1; -; Genomic_DNA.
DR   EMBL; CM000207; EAN77332.1; -; Genomic_DNA.
DR   RefSeq; XP_827661.1; XM_822568.1.
DR   RefSeq; XP_827662.1; XM_822569.1.
DR   PDB; 4V8M; EM; 5.57 A; Bu=1-308.
DR   PDBsum; 4V8M; -.
DR   AlphaFoldDB; Q38CY8; -.
DR   EMDB; EMD-17208; -.
DR   EMDB; EMD-17212; -.
DR   IntAct; Q38CY8; 1.
DR   STRING; 185431.Q38CY8; -.
DR   PaxDb; 5691-EAN77331; -.
DR   GeneID; 3661199; -.
DR   GeneID; 3661200; -.
DR   KEGG; tbr:Tb09.244.2730; -.
DR   KEGG; tbr:Tb09.244.2740; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.15110; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.15170; -.
DR   eggNOG; KOG0875; Eukaryota.
DR   InParanoid; Q38CY8; -.
DR   OMA; CQIASAH; -.
DR   OrthoDB; 1105861at2759; -.
DR   Proteomes; UP000008524; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005840; C:ribosome; ISM:GeneDB.
DR   GO; GO:0008097; F:5S rRNA binding; ISA:GeneDB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR   GO; GO:0042255; P:ribosome assembly; ISM:GeneDB.
DR   GO; GO:0006412; P:translation; ISM:GeneDB.
DR   CDD; cd00432; Ribosomal_L18_L5e; 1.
DR   Gene3D; 3.30.420.100; -; 1.
DR   HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR   InterPro; IPR005485; Rbsml_uL18_euk/arc.
DR   InterPro; IPR025607; Ribosomal_uL18_C_euk.
DR   PANTHER; PTHR23410:SF12; 60S RIBOSOMAL PROTEIN L5; 1.
DR   PANTHER; PTHR23410; RIBOSOMAL PROTEIN L5-RELATED; 1.
DR   Pfam; PF14204; Ribosomal_L18_c; 1.
DR   Pfam; PF17144; Ribosomal_L5e; 1.
DR   PRINTS; PR00058; RIBOSOMALL5.
DR   SUPFAM; SSF53137; Translational machinery components; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4V8M};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW   ECO:0000313|EMBL:EAN77332.1}.
FT   DOMAIN          245..299
FT                   /note="Large ribosomal subunit protein uL18 C-terminal
FT                   eukaryotes"
FT                   /evidence="ECO:0000259|Pfam:PF14204"
FT   REGION          258..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..276
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  34636 MW;  904463B57641A60B CRC64;
     MTFVKVVKNK AYYKRFQVKY RRRREGKTDY HARRRMVLQD KTKFGTPKYR LVVRITNRDV
     IAQIVHAKVV GDEVVMAAYS HELPLFGIEH GLTNYAAAYA TGLLVARRML AKLGLAEKFV
     GVKEVDGSYA AVRTKDDDQG DDESRFPFKA ILDVGLARTT TGARVFGVLK GAVDGGLAVP
     HRPNRFPGYN KESDALNAKV HRDRIFGRHV ADYLKQVREE ASSNPDEKTC QFSKFIAAKV
     SPDDMEGMYK RAHAAIRADP TKRRAKKERP AEAKPKKYNT VKLTGAEKKA AAKAKVAAVI
     ERIRDRAK
//