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Protein
Submitted name:

Thymidine kinase, putative

Gene

Tb10.70.7270

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. thymidine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Thymidine kinase, putativeImported (EC:2.7.1.21Imported)
Gene namesi
ORF Names:Tb10.70.7270Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 10

Interactioni

Protein-protein interaction databases

STRINGi5691.Tb10.70.7270.

Structurei

3D structure databases

ProteinModelPortaliQ38CF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
InParanoidiQ38CF2.
KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00603. TK_CELLULAR_TYPE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38CF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHDGDGNIEL IIGPMFAGKT TELMRRVQRH KHAQRSCYII NYSRNSYQNQ
60 70 80 90 100
RLSTHDQLSL TANVSIAKLS EVCDEWRDYD VIAVDNGQFF PDVVGFCARA
110 120 130 140 150
ANEGKTVIVS ALDVDCRETP FDEVCRLVPR AESVLKLSAV CMECHEHDAF
160 170 180 190 200
LTYRTIESNE RELYGGADMY LAVCRWCYKQ LTMSHVDAQK TSASTAAVVP
210 220 230 240 250
NGAHGRIELI IGPMFAGKTT ELMRRVQRHK HAQRSCYIIK YTGDTRYSEG
260 270 280 290 300
AITSHDQRAL TANVSVSNLH DVGDEWRKYD VIAVDEGQFF PGVAAFCSKA
310 320 330 340 350
ADSGKVVIVS ALDADYLQEP FEEICLLVSR ADSVVKLSAV CMECHNRKAS
360 370 380 390 400
FTYRTVKSDE RKLVGGSDMY MSVCRSCYET KRNMVQTEKY IYSCVGINEG
410 420 430 440 450
SYSECSPGPS ERSSAGTSGV QTSVKVDEQN CTEPNTEAKK MPLKRKRNQM

AVDTT
Length:455
Mass (Da):50,844
Last modified:November 22, 2005 - v1
Checksum:i23B651D305F9BB8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN77518.1.
RefSeqiXP_822346.1. XM_817253.1.

Genome annotation databases

GeneIDi3662841.
KEGGitbr:Tb10.70.7270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN77518.1.
RefSeqiXP_822346.1. XM_817253.1.

3D structure databases

ProteinModelPortaliQ38CF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.Tb10.70.7270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3662841.
KEGGitbr:Tb10.70.7270.

Phylogenomic databases

eggNOGiCOG1435.
InParanoidiQ38CF2.
KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00603. TK_CELLULAR_TYPE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.

Entry informationi

Entry nameiQ38CF2_TRYB2
AccessioniPrimary (citable) accession number: Q38CF2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: February 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.