Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q38C91

- Q38C91_TRYB2

UniProt

Q38C91 - Q38C91_TRYB2

Protein
Submitted name:

Methionyl-tRNA synthetase, putative

Gene

Tb10.70.6470

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei271 – 2711Sulfate 1Imported
    Binding sitei434 – 4341Sulfate 2Imported
    Binding sitei438 – 4381Sulfate 2Imported
    Binding sitei714 – 7141Sulfate 1; via carbonyl oxygenImported

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. methionine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseImported, Ligase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methionyl-tRNA synthetase, putativeImported (EC:6.1.1.10Imported)
    Gene namesi
    ORF Names:Tb10.70.6470Imported
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
    Taxonomic identifieri999953 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    ProteomesiUP000008524: Chromosome 10

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi5691.Tb10.70.6470.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EG1X-ray2.90A/B237-773[»]
    4EG3X-ray2.94A/B237-773[»]
    4EG4X-ray3.15A/B237-773[»]
    4EG5X-ray3.10A/B237-773[»]
    4EG6X-ray2.90A/B235-773[»]
    4EG7X-ray2.75A/B237-773[»]
    4EG8X-ray2.60A/B237-773[»]
    4EGAX-ray2.70A/B237-773[»]
    4MVWX-ray2.90A/B237-773[»]
    4MVXX-ray2.55A/B237-773[»]
    4MVYX-ray2.31A/B237-773[»]
    4MW0X-ray2.20A/B237-773[»]
    4MW1X-ray2.49A/B237-773[»]
    4MW2X-ray2.30A/B237-773[»]
    4MW4X-ray2.50A/B237-773[»]
    4MW5X-ray2.35A/B237-773[»]
    4MW6X-ray2.56A/B237-773[»]
    4MW7X-ray2.75A/B237-773[»]
    4MW9X-ray2.65A/B237-773[»]
    4MWBX-ray2.31A/B237-773[»]
    4MWCX-ray2.65A/B237-773[»]
    4MWDX-ray2.25A/B237-773[»]
    4MWEX-ray2.45A/B237-773[»]
    ProteinModelPortaliQ38C91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0143.
    HOGENOMiHOG000200401.
    KOiK01874.
    OMAiIMAKEIS.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProiIPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q38C91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKLLSEKA NSQALKVLLC SYYVKRPVEV SLSGAYATPI LHHPAFKQPI    50
    IAPNEMARVI LFYSVEPTSN NGGAADSSNG DGTASPVAGL TNLTLEHETW 100
    LEWEATTFTR AVHPLYTQRR QTAESLAVFS YLDKKISEND DRCVYSPAVE 150
    GKGAADPTDA VSTFFIDCIV WCAVLPALCE SGVLRDSEKQ QLPHLVKWFN 200
    TFQKEQKTLI DNAFENLSVQ EAADFLRCPR VYKVSAKVEK VFFVTSPIYY 250
    VNAAPHIGHV YSTLITDVIG RYHRVKGERV FALTGTDEHG QKVAEAAKQK 300
    QVSPYDFTAA VAGEFKKCFE QMDYSIDYFI RTTNEQHKAV VKELWTKLEQ 350
    KGDIYLGRYE GWYSISDESF LTPQNITDGV DKDGNPCKVS LESGHVVTWV 400
    SEENYMFRLS AFRERLLEWY HANPGCIVPE FRRREVIRAV EKGLPDLSVS 450
    RKKETLHNWA IPVPGNPDHC VYVWLDALTN YLTGSRLRVD ESGKEVSLAD 500
    DFSELERFPA DVHVIGKDIL KFHAIYWPAF LLSAGLPLPK KIVAHGWWTK 550
    DRKKISKSLG NVFDPVEKAE EFGYDALKYF LLRESGFSDD GDYSDKNMIA 600
    RLNGELADTL GNLVMRCTSA KINVNGEWPS PAAYTEEDES LIQLIKDLPG 650
    TADHYYLIPD IQKAIIAVFD VLRAINAYVT DMAPWKLVKT DPERLRTVLY 700
    ITLEGVRVTT LLLSPILPRK SVVIFDMLGV PEVHRKGIEN FEFGAVPPGT 750
    RLGPAVEGEV LFSKRSTENT KST 773
    Length:773
    Mass (Da):86,911
    Last modified:November 22, 2005 - v1
    Checksum:i8BE9FB1CFB52A1B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000208 Genomic DNA. Translation: EAN77579.1.
    RefSeqiXP_822407.1. XM_817314.1.

    Genome annotation databases

    EnsemblProtistsiEAN77579; EAN77579; Tb10.70.6470.
    GeneIDi3662741.
    KEGGitbr:Tb10.70.6470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000208 Genomic DNA. Translation: EAN77579.1 .
    RefSeqi XP_822407.1. XM_817314.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EG1 X-ray 2.90 A/B 237-773 [» ]
    4EG3 X-ray 2.94 A/B 237-773 [» ]
    4EG4 X-ray 3.15 A/B 237-773 [» ]
    4EG5 X-ray 3.10 A/B 237-773 [» ]
    4EG6 X-ray 2.90 A/B 235-773 [» ]
    4EG7 X-ray 2.75 A/B 237-773 [» ]
    4EG8 X-ray 2.60 A/B 237-773 [» ]
    4EGA X-ray 2.70 A/B 237-773 [» ]
    4MVW X-ray 2.90 A/B 237-773 [» ]
    4MVX X-ray 2.55 A/B 237-773 [» ]
    4MVY X-ray 2.31 A/B 237-773 [» ]
    4MW0 X-ray 2.20 A/B 237-773 [» ]
    4MW1 X-ray 2.49 A/B 237-773 [» ]
    4MW2 X-ray 2.30 A/B 237-773 [» ]
    4MW4 X-ray 2.50 A/B 237-773 [» ]
    4MW5 X-ray 2.35 A/B 237-773 [» ]
    4MW6 X-ray 2.56 A/B 237-773 [» ]
    4MW7 X-ray 2.75 A/B 237-773 [» ]
    4MW9 X-ray 2.65 A/B 237-773 [» ]
    4MWB X-ray 2.31 A/B 237-773 [» ]
    4MWC X-ray 2.65 A/B 237-773 [» ]
    4MWD X-ray 2.25 A/B 237-773 [» ]
    4MWE X-ray 2.45 A/B 237-773 [» ]
    ProteinModelPortali Q38C91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5691.Tb10.70.6470.

    Chemistry

    ChEMBLi CHEMBL2146303.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi EAN77579 ; EAN77579 ; Tb10.70.6470 .
    GeneIDi 3662741.
    KEGGi tbr:Tb10.70.6470.

    Phylogenomic databases

    eggNOGi COG0143.
    HOGENOMi HOG000200401.
    KOi K01874.
    OMAi IMAKEIS.

    Miscellaneous databases

    PROi Q38C91.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProi IPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the African trypanosome Trypanosoma brucei."
      Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
      , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
      Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 927/4 GUTat10.1Imported.
    2. "Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection."
      Koh C.Y., Kim J.E., Shibata S., Ranade R.M., Yu M., Liu J., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
      Structure 20:1681-1691(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 237-773.
    3. "Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness."
      Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
      PLoS Negl. Trop. Dis. 8:e2775-e2775(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 237-773.

    Entry informationi

    Entry nameiQ38C91_TRYB2
    AccessioniPrimary (citable) accession number: Q38C91
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3