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Q38C91

- Q38C91_TRYB2

UniProt

Q38C91 - Q38C91_TRYB2

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Protein
Submitted name:

Methionyl-tRNA synthetase, putative

Gene

Tb10.70.6470

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei271 – 2711Sulfate 1Imported
Binding sitei434 – 4341Sulfate 2Imported
Binding sitei438 – 4381Sulfate 2Imported
Binding sitei714 – 7141Sulfate 1; via carbonyl oxygenImported

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. methionine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseImported, Ligase

Names & Taxonomyi

Protein namesi
Submitted name:
Methionyl-tRNA synthetase, putativeImported (EC:6.1.1.10Imported)
Gene namesi
ORF Names:Tb10.70.6470Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5691.Tb10.70.6470.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EG1X-ray2.90A/B237-773[»]
4EG3X-ray2.94A/B237-773[»]
4EG4X-ray3.15A/B237-773[»]
4EG5X-ray3.10A/B237-773[»]
4EG6X-ray2.90A/B235-773[»]
4EG7X-ray2.75A/B237-773[»]
4EG8X-ray2.60A/B237-773[»]
4EGAX-ray2.70A/B237-773[»]
4MVWX-ray2.90A/B237-773[»]
4MVXX-ray2.55A/B237-773[»]
4MVYX-ray2.31A/B237-773[»]
4MW0X-ray2.20A/B237-773[»]
4MW1X-ray2.49A/B237-773[»]
4MW2X-ray2.30A/B237-773[»]
4MW4X-ray2.50A/B237-773[»]
4MW5X-ray2.35A/B237-773[»]
4MW6X-ray2.56A/B237-773[»]
4MW7X-ray2.75A/B237-773[»]
4MW9X-ray2.65A/B237-773[»]
4MWBX-ray2.31A/B237-773[»]
4MWCX-ray2.65A/B237-773[»]
4MWDX-ray2.25A/B237-773[»]
4MWEX-ray2.45A/B237-773[»]
ProteinModelPortaliQ38C91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200401.
InParanoidiQ38C91.
KOiK01874.
OMAiIMAKEIS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38C91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKLLSEKA NSQALKVLLC SYYVKRPVEV SLSGAYATPI LHHPAFKQPI
60 70 80 90 100
IAPNEMARVI LFYSVEPTSN NGGAADSSNG DGTASPVAGL TNLTLEHETW
110 120 130 140 150
LEWEATTFTR AVHPLYTQRR QTAESLAVFS YLDKKISEND DRCVYSPAVE
160 170 180 190 200
GKGAADPTDA VSTFFIDCIV WCAVLPALCE SGVLRDSEKQ QLPHLVKWFN
210 220 230 240 250
TFQKEQKTLI DNAFENLSVQ EAADFLRCPR VYKVSAKVEK VFFVTSPIYY
260 270 280 290 300
VNAAPHIGHV YSTLITDVIG RYHRVKGERV FALTGTDEHG QKVAEAAKQK
310 320 330 340 350
QVSPYDFTAA VAGEFKKCFE QMDYSIDYFI RTTNEQHKAV VKELWTKLEQ
360 370 380 390 400
KGDIYLGRYE GWYSISDESF LTPQNITDGV DKDGNPCKVS LESGHVVTWV
410 420 430 440 450
SEENYMFRLS AFRERLLEWY HANPGCIVPE FRRREVIRAV EKGLPDLSVS
460 470 480 490 500
RKKETLHNWA IPVPGNPDHC VYVWLDALTN YLTGSRLRVD ESGKEVSLAD
510 520 530 540 550
DFSELERFPA DVHVIGKDIL KFHAIYWPAF LLSAGLPLPK KIVAHGWWTK
560 570 580 590 600
DRKKISKSLG NVFDPVEKAE EFGYDALKYF LLRESGFSDD GDYSDKNMIA
610 620 630 640 650
RLNGELADTL GNLVMRCTSA KINVNGEWPS PAAYTEEDES LIQLIKDLPG
660 670 680 690 700
TADHYYLIPD IQKAIIAVFD VLRAINAYVT DMAPWKLVKT DPERLRTVLY
710 720 730 740 750
ITLEGVRVTT LLLSPILPRK SVVIFDMLGV PEVHRKGIEN FEFGAVPPGT
760 770
RLGPAVEGEV LFSKRSTENT KST
Length:773
Mass (Da):86,911
Last modified:November 22, 2005 - v1
Checksum:i8BE9FB1CFB52A1B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000208 Genomic DNA. Translation: EAN77579.1.
RefSeqiXP_822407.1. XM_817314.1.

Genome annotation databases

GeneIDi3662741.
KEGGitbr:Tb10.70.6470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000208 Genomic DNA. Translation: EAN77579.1 .
RefSeqi XP_822407.1. XM_817314.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EG1 X-ray 2.90 A/B 237-773 [» ]
4EG3 X-ray 2.94 A/B 237-773 [» ]
4EG4 X-ray 3.15 A/B 237-773 [» ]
4EG5 X-ray 3.10 A/B 237-773 [» ]
4EG6 X-ray 2.90 A/B 235-773 [» ]
4EG7 X-ray 2.75 A/B 237-773 [» ]
4EG8 X-ray 2.60 A/B 237-773 [» ]
4EGA X-ray 2.70 A/B 237-773 [» ]
4MVW X-ray 2.90 A/B 237-773 [» ]
4MVX X-ray 2.55 A/B 237-773 [» ]
4MVY X-ray 2.31 A/B 237-773 [» ]
4MW0 X-ray 2.20 A/B 237-773 [» ]
4MW1 X-ray 2.49 A/B 237-773 [» ]
4MW2 X-ray 2.30 A/B 237-773 [» ]
4MW4 X-ray 2.50 A/B 237-773 [» ]
4MW5 X-ray 2.35 A/B 237-773 [» ]
4MW6 X-ray 2.56 A/B 237-773 [» ]
4MW7 X-ray 2.75 A/B 237-773 [» ]
4MW9 X-ray 2.65 A/B 237-773 [» ]
4MWB X-ray 2.31 A/B 237-773 [» ]
4MWC X-ray 2.65 A/B 237-773 [» ]
4MWD X-ray 2.25 A/B 237-773 [» ]
4MWE X-ray 2.45 A/B 237-773 [» ]
ProteinModelPortali Q38C91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5691.Tb10.70.6470.

Chemistry

ChEMBLi CHEMBL2146303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3662741.
KEGGi tbr:Tb10.70.6470.

Phylogenomic databases

eggNOGi COG0143.
HOGENOMi HOG000200401.
InParanoidi Q38C91.
KOi K01874.
OMAi IMAKEIS.

Miscellaneous databases

PROi Q38C91.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProi IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  2. "Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection."
    Koh C.Y., Kim J.E., Shibata S., Ranade R.M., Yu M., Liu J., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
    Structure 20:1681-1691(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 237-773.
  3. "Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness."
    Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
    PLoS Negl. Trop. Dis. 8:e2775-e2775(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 237-773.

Entry informationi

Entry nameiQ38C91_TRYB2
AccessioniPrimary (citable) accession number: Q38C91
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3