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Q38C91 (Q38C91_TRYB2) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=6.1.1.10 EMBL EAN77579.1
Gene names
ORF Names:Tb10.70.6470 EMBL EAN77579.1
OrganismTrypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]
Taxonomic identifier999953 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequences

Sequence LengthMass (Da)Tools
Q38C91 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 8BE9FB1CFB52A1B1

FASTA77386,911
        10         20         30         40         50         60 
MALKLLSEKA NSQALKVLLC SYYVKRPVEV SLSGAYATPI LHHPAFKQPI IAPNEMARVI 

        70         80         90        100        110        120 
LFYSVEPTSN NGGAADSSNG DGTASPVAGL TNLTLEHETW LEWEATTFTR AVHPLYTQRR 

       130        140        150        160        170        180 
QTAESLAVFS YLDKKISEND DRCVYSPAVE GKGAADPTDA VSTFFIDCIV WCAVLPALCE 

       190        200        210        220        230        240 
SGVLRDSEKQ QLPHLVKWFN TFQKEQKTLI DNAFENLSVQ EAADFLRCPR VYKVSAKVEK 

       250        260        270        280        290        300 
VFFVTSPIYY VNAAPHIGHV YSTLITDVIG RYHRVKGERV FALTGTDEHG QKVAEAAKQK 

       310        320        330        340        350        360 
QVSPYDFTAA VAGEFKKCFE QMDYSIDYFI RTTNEQHKAV VKELWTKLEQ KGDIYLGRYE 

       370        380        390        400        410        420 
GWYSISDESF LTPQNITDGV DKDGNPCKVS LESGHVVTWV SEENYMFRLS AFRERLLEWY 

       430        440        450        460        470        480 
HANPGCIVPE FRRREVIRAV EKGLPDLSVS RKKETLHNWA IPVPGNPDHC VYVWLDALTN 

       490        500        510        520        530        540 
YLTGSRLRVD ESGKEVSLAD DFSELERFPA DVHVIGKDIL KFHAIYWPAF LLSAGLPLPK 

       550        560        570        580        590        600 
KIVAHGWWTK DRKKISKSLG NVFDPVEKAE EFGYDALKYF LLRESGFSDD GDYSDKNMIA 

       610        620        630        640        650        660 
RLNGELADTL GNLVMRCTSA KINVNGEWPS PAAYTEEDES LIQLIKDLPG TADHYYLIPD 

       670        680        690        700        710        720 
IQKAIIAVFD VLRAINAYVT DMAPWKLVKT DPERLRTVLY ITLEGVRVTT LLLSPILPRK 

       730        740        750        760        770 
SVVIFDMLGV PEVHRKGIEN FEFGAVPPGT RLGPAVEGEV LFSKRSTENT KST 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the African trypanosome Trypanosoma brucei."
Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. expand/collapse author list , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 927/4 GUTat10.1 EMBL EAN77579.1.
[2]"Urea-based Inhibitors of Trypanosoma brucei Methionyl-tRNA Synthetase Show Promising Selectivity and Bioavailability."
Shibata S., Gillespie J.R., Pefley R.M., Koh C.Y., Kim J.E., Laydbak J.U., Hulverson M.A., Zucker F., Hol W.G.J., Verlinde C.L.M.J., Buckner F.S., Fan E.
Submitted (SEP-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 237-773.
[3]"Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization."
Shibata S., Gillespie J.R., Ranade R.M., Koh C.Y., Kim J.E., Laydbak J.U., Zucker F.H., Hol W.G., Verlinde C.L., Buckner F.S., Fan E.
J. Med. Chem. 55:6342-6351(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 237-773.
[4]"Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection."
Koh C.Y., Kim J.E., Shibata S., Ranade R.M., Yu M., Liu J., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
Structure 20:1681-1691(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 237-773.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000208 Genomic DNA. Translation: EAN77579.1.
RefSeqXP_822407.1. XM_817314.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TUNX-ray2.55A/B237-773[»]
3U1EX-ray2.31A/B237-773[»]
3U1FX-ray2.20A/B237-773[»]
3U1GX-ray2.35A/B237-773[»]
3U1ZX-ray2.90A/B237-773[»]
3U20X-ray2.49A/B237-773[»]
4EG1X-ray2.90A/B237-773[»]
4EG3X-ray2.94A/B237-773[»]
4EG4X-ray3.15A/B237-773[»]
4EG5X-ray3.10A/B237-773[»]
4EG6X-ray2.90A/B235-773[»]
4EG7X-ray2.75A/B237-773[»]
4EG8X-ray2.60A/B237-773[»]
4EGAX-ray2.70A/B237-773[»]
ProteinModelPortalQ38C91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5691.Tb10.70.6470.

Chemistry

ChEMBLCHEMBL2146303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAN77579; EAN77579; Tb10.70.6470.
GeneID3662741.
KEGGtbr:Tb10.70.6470.

Phylogenomic databases

eggNOGCOG0143.
HOGENOMHOG000200401.
KOK01874.
OMAIMAKEIS.
ProtClustDBCLSZ2440184.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR01041. TRNASYNTHMET.
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00398. metG. 1 hit.
ProtoNetSearch...

Other

PROQ38C91.

Entry information

Entry nameQ38C91_TRYB2
AccessionPrimary (citable) accession number: Q38C91
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)