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Protein
Submitted name:

Methionyl-tRNA synthetase, putative

Gene

Tb10.70.6470

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseImported, Ligase

Enzyme and pathway databases

BRENDAi6.1.1.10. 6519.

Names & Taxonomyi

Protein namesi
Submitted name:
Methionyl-tRNA synthetase, putativeImported (EC:6.1.1.10Imported)
Gene namesi
ORF Names:Tb10.70.6470Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5691.EAN77579.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EG1X-ray2.90A/B237-773[»]
4EG3X-ray2.94A/B237-773[»]
4EG4X-ray3.15A/B237-773[»]
4EG5X-ray3.10A/B237-773[»]
4EG6X-ray2.90A/B235-773[»]
4EG7X-ray2.75A/B237-773[»]
4EG8X-ray2.60A/B237-773[»]
4EGAX-ray2.70A/B237-773[»]
4MVWX-ray2.90A/B237-773[»]
4MVXX-ray2.55A/B237-773[»]
4MVYX-ray2.31A/B237-773[»]
4MW0X-ray2.20A/B237-773[»]
4MW1X-ray2.49A/B237-773[»]
4MW2X-ray2.30A/B237-773[»]
4MW4X-ray2.50A/B237-773[»]
4MW5X-ray2.35A/B237-773[»]
4MW6X-ray2.56A/B237-773[»]
4MW7X-ray2.75A/B237-773[»]
4MW9X-ray2.65A/B237-773[»]
4MWBX-ray2.31A/B237-773[»]
4MWCX-ray2.65A/B237-773[»]
4MWDX-ray2.25A/B237-773[»]
4MWEX-ray2.45A/B237-773[»]
ProteinModelPortaliQ38C91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200401.
InParanoidiQ38C91.
KOiK01874.
OMAiKATINEM.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38C91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKLLSEKA NSQALKVLLC SYYVKRPVEV SLSGAYATPI LHHPAFKQPI
60 70 80 90 100
IAPNEMARVI LFYSVEPTSN NGGAADSSNG DGTASPVAGL TNLTLEHETW
110 120 130 140 150
LEWEATTFTR AVHPLYTQRR QTAESLAVFS YLDKKISEND DRCVYSPAVE
160 170 180 190 200
GKGAADPTDA VSTFFIDCIV WCAVLPALCE SGVLRDSEKQ QLPHLVKWFN
210 220 230 240 250
TFQKEQKTLI DNAFENLSVQ EAADFLRCPR VYKVSAKVEK VFFVTSPIYY
260 270 280 290 300
VNAAPHIGHV YSTLITDVIG RYHRVKGERV FALTGTDEHG QKVAEAAKQK
310 320 330 340 350
QVSPYDFTAA VAGEFKKCFE QMDYSIDYFI RTTNEQHKAV VKELWTKLEQ
360 370 380 390 400
KGDIYLGRYE GWYSISDESF LTPQNITDGV DKDGNPCKVS LESGHVVTWV
410 420 430 440 450
SEENYMFRLS AFRERLLEWY HANPGCIVPE FRRREVIRAV EKGLPDLSVS
460 470 480 490 500
RKKETLHNWA IPVPGNPDHC VYVWLDALTN YLTGSRLRVD ESGKEVSLAD
510 520 530 540 550
DFSELERFPA DVHVIGKDIL KFHAIYWPAF LLSAGLPLPK KIVAHGWWTK
560 570 580 590 600
DRKKISKSLG NVFDPVEKAE EFGYDALKYF LLRESGFSDD GDYSDKNMIA
610 620 630 640 650
RLNGELADTL GNLVMRCTSA KINVNGEWPS PAAYTEEDES LIQLIKDLPG
660 670 680 690 700
TADHYYLIPD IQKAIIAVFD VLRAINAYVT DMAPWKLVKT DPERLRTVLY
710 720 730 740 750
ITLEGVRVTT LLLSPILPRK SVVIFDMLGV PEVHRKGIEN FEFGAVPPGT
760 770
RLGPAVEGEV LFSKRSTENT KST
Length:773
Mass (Da):86,911
Last modified:November 22, 2005 - v1
Checksum:i8BE9FB1CFB52A1B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN77579.1.
RefSeqiXP_822407.1. XM_817314.1.

Genome annotation databases

GeneIDi3662741.
KEGGitbr:Tb10.70.6470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN77579.1.
RefSeqiXP_822407.1. XM_817314.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EG1X-ray2.90A/B237-773[»]
4EG3X-ray2.94A/B237-773[»]
4EG4X-ray3.15A/B237-773[»]
4EG5X-ray3.10A/B237-773[»]
4EG6X-ray2.90A/B235-773[»]
4EG7X-ray2.75A/B237-773[»]
4EG8X-ray2.60A/B237-773[»]
4EGAX-ray2.70A/B237-773[»]
4MVWX-ray2.90A/B237-773[»]
4MVXX-ray2.55A/B237-773[»]
4MVYX-ray2.31A/B237-773[»]
4MW0X-ray2.20A/B237-773[»]
4MW1X-ray2.49A/B237-773[»]
4MW2X-ray2.30A/B237-773[»]
4MW4X-ray2.50A/B237-773[»]
4MW5X-ray2.35A/B237-773[»]
4MW6X-ray2.56A/B237-773[»]
4MW7X-ray2.75A/B237-773[»]
4MW9X-ray2.65A/B237-773[»]
4MWBX-ray2.31A/B237-773[»]
4MWCX-ray2.65A/B237-773[»]
4MWDX-ray2.25A/B237-773[»]
4MWEX-ray2.45A/B237-773[»]
ProteinModelPortaliQ38C91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.EAN77579.

Chemistry

BindingDBiQ38C91.
ChEMBLiCHEMBL2146303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3662741.
KEGGitbr:Tb10.70.6470.

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200401.
InParanoidiQ38C91.
KOiK01874.
OMAiKATINEM.

Enzyme and pathway databases

BRENDAi6.1.1.10. 6519.

Miscellaneous databases

PROiQ38C91.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  2. "Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection."
    Koh C.Y., Kim J.E., Shibata S., Ranade R.M., Yu M., Liu J., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
    Structure 20:1681-1691(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 237-773.
  3. "Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness."
    Koh C.Y., Kim J.E., Wetzel A.B., de van der Schueren W.J., Shibata S., Ranade R.M., Liu J., Zhang Z., Gillespie J.R., Buckner F.S., Verlinde C.L., Fan E., Hol W.G.
    PLoS Negl. Trop. Dis. 8:e2775-e2775(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 237-773.

Entry informationi

Entry nameiQ38C91_TRYB2
AccessioniPrimary (citable) accession number: Q38C91
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 24, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.