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Protein

WD repeat-containing protein LWD2

Gene

LWD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Clock protein essential for the proper expression phase and period length of both the oscillator and output genes known to participate in photoperiod sensing. Required for the expression of APRR9, APRR7, and APRR5. Regulated by APRR9 and APRR7 at the transcriptional level, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).2 Publications

GO - Biological processi

  • entrainment of circadian clock by photoperiod Source: TAIR
  • photoperiodism, flowering Source: TAIR
  • rhythmic process Source: UniProtKB-KW

Keywordsi

Biological processBiological rhythms, Sensory transduction

Enzyme and pathway databases

ReactomeiR-ATH-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein LWD2
Alternative name(s):
Protein ANTHOCYANIN 11-B
Short name:
AtAN11-B
Protein LIGHT-REGULATED WD2
WD repeat-containing protein AN11-B
Gene namesi
Name:LWD2
Synonyms:AN11B
Ordered Locus Names:At3g26640
ORF Names:MLJ15.3, orf10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G26640
TAIRilocus:2090792 AT3G26640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Plants lacking LWD2 do not show obvious phenotypic alterations. Plants lacking both LWD1 and LWD2 are early flowering and this phenotype is more prominent under short-day conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003631401 – 346WD repeat-containing protein LWD2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38960

Expressioni

Developmental stagei

Constant expression level.1 Publication

Inductioni

Circadian-regulation. Up-regulated y virus infection.2 Publications

Gene expression databases

ExpressionAtlasiQ38960 baseline and differential
GenevisibleiQ38960 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G26640.1

Structurei

3D structure databases

ProteinModelPortaliQ38960
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 121WD 1Add BLAST43
Repeati133 – 173WD 2Add BLAST41
Repeati176 – 214WD 3Add BLAST39
Repeati265 – 305WD 4Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0290 Eukaryota
ENOG410XQ78 LUCA
HOGENOMiHOG000260968
InParanoidiQ38960
OMAiGSARMFD
OrthoDBiEOG09360DOV
PhylomeDBiQ38960

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q38960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSSDQIQN GSEEQSKRSE IYTYEAPWQI YAMNWSIRRD KKYRLAITSL
60 70 80 90 100
IEQYPNRVEI VQLDESNGEI RSDPNLCFEH PYPPTKTSFI PDKECQRPDL
110 120 130 140 150
LATSSDFLRL WRISDDESRV ELKSCLSSDK NSEFSGPITS FDWNEAEPRR
160 170 180 190 200
IGTSSIDTTC TIWDIEREVV DTQLIAHDKE VYDIAWGGVG VFASVSEDGS
210 220 230 240 250
VRVFDLRDKE HSTIIYESGE PSTPLVRLSW NKQDPRYMAT VIMGSAKIVV
260 270 280 290 300
LDIRFPALPV VELQRHQASV NAIAWAPHSS SHICSAGDDS QALIWDISSM
310 320 330 340
GQHVEGGLDP ILAYTAGAEV EQLQWSSSQP DWVAIAFSNK LQILRV
Length:346
Mass (Da):39,092
Last modified:November 1, 1996 - v1
Checksum:iC71DB62672451214
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70I → V in AAO42231 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97488 mRNA Translation: CAA66120.1
X98130 Genomic DNA Translation: CAA66815.1
AB026648 Genomic DNA Translation: BAB01729.1
CP002686 Genomic DNA Translation: AEE77190.1
BT004214 mRNA Translation: AAO42231.1
AY086141 mRNA Translation: AAM63346.1
BT020361 mRNA Translation: AAV85716.1
RefSeqiNP_189298.1, NM_113575.4
UniGeneiAt.19781

Genome annotation databases

EnsemblPlantsiAT3G26640.1; AT3G26640.1; AT3G26640
GeneIDi822276
GrameneiAT3G26640.1; AT3G26640.1; AT3G26640
KEGGiath:AT3G26640

Similar proteinsi

Entry informationi

Entry nameiLWD2_ARATH
AccessioniPrimary (citable) accession number: Q38960
Secondary accession number(s): Q84W53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health