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Protein

WD repeat-containing protein LWD2

Gene

LWD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Clock protein essential for the proper expression phase and period length of both the oscillator and output genes known to participate in photoperiod sensing. Required for the expression of APRR9, APRR7, and APRR5. Regulated by APRR9 and APRR7 at the transcriptional level, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).2 Publications

GO - Biological processi

  • entrainment of circadian clock by photoperiod Source: TAIR
  • photoperiodism, flowering Source: TAIR
  • rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein LWD2
Alternative name(s):
Protein ANTHOCYANIN 11-B
Short name:
AtAN11-B
Protein LIGHT-REGULATED WD2
WD repeat-containing protein AN11-B
Gene namesi
Name:LWD2
Synonyms:AN11B
Ordered Locus Names:At3g26640
ORF Names:MLJ15.3, orf10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G26640.

Pathology & Biotechi

Disruption phenotypei

Plants lacking LWD2 do not show obvious phenotypic alterations. Plants lacking both LWD1 and LWD2 are early flowering and this phenotype is more prominent under short-day conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346WD repeat-containing protein LWD2PRO_0000363140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38960.
PRIDEiQ38960.

Expressioni

Developmental stagei

Constant expression level.1 Publication

Inductioni

Circadian-regulation. Up-regulated y virus infection.2 Publications

Gene expression databases

GenevisibleiQ38960. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G26640.1.

Structurei

3D structure databases

ProteinModelPortaliQ38960.
SMRiQ38960. Positions 40-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 12143WD 1Add
BLAST
Repeati133 – 17341WD 2Add
BLAST
Repeati176 – 21439WD 3Add
BLAST
Repeati265 – 30541WD 4Add
BLAST

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0290. Eukaryota.
ENOG410XQ78. LUCA.
HOGENOMiHOG000260968.
InParanoidiQ38960.
OMAiMATVIMG.
OrthoDBiEOG09360DOV.
PhylomeDBiQ38960.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSSDQIQN GSEEQSKRSE IYTYEAPWQI YAMNWSIRRD KKYRLAITSL
60 70 80 90 100
IEQYPNRVEI VQLDESNGEI RSDPNLCFEH PYPPTKTSFI PDKECQRPDL
110 120 130 140 150
LATSSDFLRL WRISDDESRV ELKSCLSSDK NSEFSGPITS FDWNEAEPRR
160 170 180 190 200
IGTSSIDTTC TIWDIEREVV DTQLIAHDKE VYDIAWGGVG VFASVSEDGS
210 220 230 240 250
VRVFDLRDKE HSTIIYESGE PSTPLVRLSW NKQDPRYMAT VIMGSAKIVV
260 270 280 290 300
LDIRFPALPV VELQRHQASV NAIAWAPHSS SHICSAGDDS QALIWDISSM
310 320 330 340
GQHVEGGLDP ILAYTAGAEV EQLQWSSSQP DWVAIAFSNK LQILRV
Length:346
Mass (Da):39,092
Last modified:November 1, 1996 - v1
Checksum:iC71DB62672451214
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701I → V in AAO42231 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97488 mRNA. Translation: CAA66120.1.
X98130 Genomic DNA. Translation: CAA66815.1.
AB026648 Genomic DNA. Translation: BAB01729.1.
CP002686 Genomic DNA. Translation: AEE77190.1.
BT004214 mRNA. Translation: AAO42231.1.
AY086141 mRNA. Translation: AAM63346.1.
BT020361 mRNA. Translation: AAV85716.1.
RefSeqiNP_189298.1. NM_113575.3.
UniGeneiAt.19781.

Genome annotation databases

EnsemblPlantsiAT3G26640.1; AT3G26640.1; AT3G26640.
GeneIDi822276.
GrameneiAT3G26640.1; AT3G26640.1; AT3G26640.
KEGGiath:AT3G26640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97488 mRNA. Translation: CAA66120.1.
X98130 Genomic DNA. Translation: CAA66815.1.
AB026648 Genomic DNA. Translation: BAB01729.1.
CP002686 Genomic DNA. Translation: AEE77190.1.
BT004214 mRNA. Translation: AAO42231.1.
AY086141 mRNA. Translation: AAM63346.1.
BT020361 mRNA. Translation: AAV85716.1.
RefSeqiNP_189298.1. NM_113575.3.
UniGeneiAt.19781.

3D structure databases

ProteinModelPortaliQ38960.
SMRiQ38960. Positions 40-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G26640.1.

Proteomic databases

PaxDbiQ38960.
PRIDEiQ38960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G26640.1; AT3G26640.1; AT3G26640.
GeneIDi822276.
GrameneiAT3G26640.1; AT3G26640.1; AT3G26640.
KEGGiath:AT3G26640.

Organism-specific databases

TAIRiAT3G26640.

Phylogenomic databases

eggNOGiKOG0290. Eukaryota.
ENOG410XQ78. LUCA.
HOGENOMiHOG000260968.
InParanoidiQ38960.
OMAiMATVIMG.
OrthoDBiEOG09360DOV.
PhylomeDBiQ38960.

Miscellaneous databases

PROiQ38960.

Gene expression databases

GenevisibleiQ38960. AT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLWD2_ARATH
AccessioniPrimary (citable) accession number: Q38960
Secondary accession number(s): Q84W53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.