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Protein

Glutamate dehydrogenase 2

Gene

GDH2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102PROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: TAIR
  • cobalt ion binding Source: TAIR
  • copper ion binding Source: TAIR
  • glutamate dehydrogenase (NAD+) activity Source: TAIR
  • glutamate dehydrogenase [NAD(P)+] activity Source: TAIR
  • zinc ion binding Source: TAIR

GO - Biological processi

  • cellular amino acid metabolic process Source: InterPro
  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT5G07440-MONOMER
MetaCyc:AT5G07440-MONOMER
ReactomeiR-ATH-2151201 Transcriptional activation of mitochondrial biogenesis
R-ATH-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 2 (EC:1.4.1.3)
Short name:
GDH 2
Gene namesi
Name:GDH2
Ordered Locus Names:At5g07440
ORF Names:T2I1_150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G07440
TAIRilocus:2183379 AT5G07440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827461 – 411Glutamate dehydrogenase 2Add BLAST411

Proteomic databases

PaxDbiQ38946
PRIDEiQ38946

PTM databases

iPTMnetiQ38946
SwissPalmiQ38946

Expressioni

Gene expression databases

ExpressionAtlasiQ38946 baseline and differential
GenevisibleiQ38946 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G07440.1

Structurei

3D structure databases

ProteinModelPortaliQ38946
SMRiQ38946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2250 Eukaryota
COG0334 LUCA
HOGENOMiHOG000243801
InParanoidiQ38946
KOiK00261
OMAiGSHGRES
OrthoDBiEOG09360A6S
PhylomeDBiQ38946

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q38946-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNALAATNRN FRHASRILGL DSKIERSLMI PFREIKVECT IPKDDGTLVS
60 70 80 90 100
YIGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVADIPYGG
110 120 130 140 150
AKGGIGCSPR DLSLSELERL TRVFTQKIHD LIGIHTDVPA PDMGTNAQTM
160 170 180 190 200
AWILDEYSKF HGHSPAVVTG KPIDLGGSLG REAATGRGVV FATEALLAEY
210 220 230 240 250
GKSIQGLTFV IQGFGNVGTW AAKLIHEKGG KVVAVSDITG AIRNPEGIDI
260 270 280 290 300
NALIKHKDAT GSLNDFNGGD AMNSDELLIH ECDVLIPCAL GGVLNKENAG
310 320 330 340 350
DVKAKFIVEA ANHPTDPDAD EILSKKGVII LPDIYANAGG VTVSYFEWVQ
360 370 380 390 400
NIQGFMWEEE KVNLELQKYM TRAFHNIKTM CHTHSCNLRM GAFTLGVNRV
410
ARATQLRGWE A
Length:411
Mass (Da):44,699
Last modified:November 1, 1996 - v1
Checksum:i91267768215A15CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232V → I AA sequence (PubMed:11743114).Curated1
Sequence conflicti242 – 243IR → LK AA sequence (PubMed:11743114).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56635 mRNA Translation: AAB01222.1
AL163912 Genomic DNA Translation: CAB87933.1
CP002688 Genomic DNA Translation: AED91157.1
CP002688 Genomic DNA Translation: AED91158.1
PIRiT49883
RefSeqiNP_001119183.1, NM_001125711.2 [Q38946-1]
NP_196361.1, NM_120826.3 [Q38946-1]
UniGeneiAt.21712

Genome annotation databases

EnsemblPlantsiAT5G07440.1; AT5G07440.1; AT5G07440 [Q38946-1]
AT5G07440.2; AT5G07440.2; AT5G07440 [Q38946-1]
GeneIDi830635
GrameneiAT5G07440.1; AT5G07440.1; AT5G07440 [Q38946-1]
AT5G07440.2; AT5G07440.2; AT5G07440 [Q38946-1]
KEGGiath:AT5G07440

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHE2_ARATH
AccessioniPrimary (citable) accession number: Q38946
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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