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Q38946

- DHE2_ARATH

UniProt

Q38946 - DHE2_ARATH

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Protein

Glutamate dehydrogenase 2

Gene
GDH2, At5g07440, T2I1_150
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021 By similarity

GO - Molecular functioni

  1. ATP binding Source: TAIR
  2. cobalt ion binding Source: TAIR
  3. copper ion binding Source: TAIR
  4. glutamate dehydrogenase (NAD+) activity Source: TAIR
  5. glutamate dehydrogenase [NAD(P)+] activity Source: TAIR
  6. zinc ion binding Source: TAIR

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
  2. response to cadmium ion Source: TAIR
  3. response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT5G07440-MONOMER.
ARA:GQT-326-MONOMER.
ARA:GQT-327-MONOMER.
MetaCyc:AT5G07440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 2 (EC:1.4.1.3)
Short name:
GDH 2
Gene namesi
Name:GDH2
Ordered Locus Names:At5g07440
ORF Names:T2I1_150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G07440.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: TAIR
  2. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glutamate dehydrogenase 2PRO_0000182746Add
BLAST

Proteomic databases

PaxDbiQ38946.
PRIDEiQ38946.

Expressioni

Gene expression databases

GenevestigatoriQ38946.

Structurei

3D structure databases

ProteinModelPortaliQ38946.
SMRiQ38946. Positions 11-408.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243801.
InParanoidiQ38946.
KOiK00261.
OMAiFNFDRAK.
PhylomeDBiQ38946.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q38946-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNALAATNRN FRHASRILGL DSKIERSLMI PFREIKVECT IPKDDGTLVS    50
YIGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVADIPYGG 100
AKGGIGCSPR DLSLSELERL TRVFTQKIHD LIGIHTDVPA PDMGTNAQTM 150
AWILDEYSKF HGHSPAVVTG KPIDLGGSLG REAATGRGVV FATEALLAEY 200
GKSIQGLTFV IQGFGNVGTW AAKLIHEKGG KVVAVSDITG AIRNPEGIDI 250
NALIKHKDAT GSLNDFNGGD AMNSDELLIH ECDVLIPCAL GGVLNKENAG 300
DVKAKFIVEA ANHPTDPDAD EILSKKGVII LPDIYANAGG VTVSYFEWVQ 350
NIQGFMWEEE KVNLELQKYM TRAFHNIKTM CHTHSCNLRM GAFTLGVNRV 400
ARATQLRGWE A 411
Length:411
Mass (Da):44,699
Last modified:November 1, 1996 - v1
Checksum:i91267768215A15CF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321V → I AA sequence 1 Publication
Sequence conflicti242 – 2432IR → LK AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56635 mRNA. Translation: AAB01222.1.
AL163912 Genomic DNA. Translation: CAB87933.1.
CP002688 Genomic DNA. Translation: AED91157.1.
CP002688 Genomic DNA. Translation: AED91158.1.
PIRiT49883.
RefSeqiNP_001119183.1. NM_001125711.1. [Q38946-1]
NP_196361.1. NM_120826.2. [Q38946-1]
UniGeneiAt.21712.

Genome annotation databases

EnsemblPlantsiAT5G07440.1; AT5G07440.1; AT5G07440. [Q38946-1]
AT5G07440.2; AT5G07440.2; AT5G07440. [Q38946-1]
GeneIDi830635.
KEGGiath:AT5G07440.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56635 mRNA. Translation: AAB01222.1 .
AL163912 Genomic DNA. Translation: CAB87933.1 .
CP002688 Genomic DNA. Translation: AED91157.1 .
CP002688 Genomic DNA. Translation: AED91158.1 .
PIRi T49883.
RefSeqi NP_001119183.1. NM_001125711.1. [Q38946-1 ]
NP_196361.1. NM_120826.2. [Q38946-1 ]
UniGenei At.21712.

3D structure databases

ProteinModelPortali Q38946.
SMRi Q38946. Positions 11-408.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q38946.
PRIDEi Q38946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G07440.1 ; AT5G07440.1 ; AT5G07440 . [Q38946-1 ]
AT5G07440.2 ; AT5G07440.2 ; AT5G07440 . [Q38946-1 ]
GeneIDi 830635.
KEGGi ath:AT5G07440.

Organism-specific databases

GeneFarmi 2247. 178.
TAIRi AT5G07440.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243801.
InParanoidi Q38946.
KOi K00261.
OMAi FNFDRAK.
PhylomeDBi Q38946.

Enzyme and pathway databases

BioCyci ARA:AT5G07440-MONOMER.
ARA:GQT-326-MONOMER.
ARA:GQT-327-MONOMER.
MetaCyc:AT5G07440-MONOMER.

Miscellaneous databases

PROi Q38946.

Gene expression databases

Genevestigatori Q38946.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Turano F.J., Thakkar S.S., Weisemann J.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Proteomic approach to identify novel mitochondrial proteins in Arabidopsis."
    Kruft V., Eubel H., Jaensch L., Werhahn W., Braun H.-P.
    Plant Physiol. 127:1694-1710(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 232-243 AND 391-399, SUBCELLULAR LOCATION.
    Tissue: Leaf and Stem.
  5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiDHE2_ARATH
AccessioniPrimary (citable) accession number: Q38946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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