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Protein

Peptidyl-prolyl cis-trans isomerase FKBP15-1

Gene

FKBP15-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP15-1 (EC:5.2.1.8)
Short name:
PPIase FKBP15-1
Alternative name(s):
15 kDa FK506-binding protein
Short name:
15 kDa FKBP
FK506-binding protein 15-1
Short name:
AtFKBP15-1
FK506-binding protein 2-1
Immunophilin FKBP15-1
Rotamase
Gene namesi
Name:FKBP15-1
Ordered Locus Names:At3g25220
ORF Names:MJL12.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G25220
TAIRilocus:2090235 AT3G25220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002550826 – 153Peptidyl-prolyl cis-trans isomerase FKBP15-1Add BLAST128

Proteomic databases

PaxDbiQ38935
PRIDEiQ38935

Expressioni

Gene expression databases

ExpressionAtlasiQ38935 baseline and differential
GenevisibleiQ38935 AT

Interactioni

Protein-protein interaction databases

BioGridi7446, 7 interactors
IntActiQ38935, 7 interactors
STRINGi3702.AT3G25220.1

Structurei

3D structure databases

ProteinModelPortaliQ38935
SMRiQ38935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 140PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi150 – 153Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
HOGENOMiHOG000154887
InParanoidiQ38935
KOiK09569
OMAiKSCEFQA
OrthoDBiEOG09360S3U
PhylomeDBiQ38935

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q38935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSSASAMKA VGFLLLLTIL TLAYAKKSGD VTELQIGVKY KPQKCDLQAH
60 70 80 90 100
KGDKIKVHYR GKLTDGTVFD SSFERGDPIE FELGTGQVIP GWDQGLLGAC
110 120 130 140 150
VGEKRKLKIP SKLGYGDNGS PPKIPGGATL IFDTELVAVN GEPSSEAKSK

NEL
Length:153
Mass (Da):16,355
Last modified:September 19, 2002 - v2
Checksum:i09549E647B738CD9
GO

Sequence cautioni

The sequence AAC49390 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM65589 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72S → I in AAM65589 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52046 mRNA Translation: AAC49390.1 Different initiation.
AB026647 Genomic DNA Translation: BAB02081.1
CP002686 Genomic DNA Translation: AEE76994.1
AY062776 mRNA Translation: AAL32854.1
AY128760 mRNA Translation: AAM91160.1
AY088043 mRNA Translation: AAM65589.1 Different initiation.
PIRiS71237
RefSeqiNP_566762.1, NM_113428.3
UniGeneiAt.6372

Genome annotation databases

EnsemblPlantsiAT3G25220.1; AT3G25220.1; AT3G25220
GeneIDi822115
GrameneiAT3G25220.1; AT3G25220.1; AT3G25220
KEGGiath:AT3G25220

Similar proteinsi

Entry informationi

Entry nameiFK151_ARATH
AccessioniPrimary (citable) accession number: Q38935
Secondary accession number(s): Q8LA41, Q9LSF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 25, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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