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Q38935

- FK151_ARATH

UniProt

Q38935 - FK151_ARATH

Protein

Peptidyl-prolyl cis-trans isomerase FKBP15-1

Gene

FKBP15-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. peptidyl-proline modification Source: RefGenome
    2. protein folding Source: UniProtKB-KW
    3. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Enzyme and pathway databases

    BioCyciARA:AT3G25220-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP15-1 (EC:5.2.1.8)
    Short name:
    PPIase FKBP15-1
    Alternative name(s):
    15 kDa FK506-binding protein
    Short name:
    15 kDa FKBP
    FK506-binding protein 15-1
    Short name:
    AtFKBP15-1
    FK506-binding protein 2-1
    Immunophilin FKBP15-1
    Rotamase
    Gene namesi
    Name:FKBP15-1
    Ordered Locus Names:At3g25220
    ORF Names:MJL12.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G25220.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: TAIR
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 153128Peptidyl-prolyl cis-trans isomerase FKBP15-1PRO_0000025508Add
    BLAST

    Proteomic databases

    PaxDbiQ38935.
    PRIDEiQ38935.

    Expressioni

    Gene expression databases

    GenevestigatoriQ38935.

    Interactioni

    Protein-protein interaction databases

    BioGridi7446. 5 interactions.
    IntActiQ38935. 7 interactions.
    STRINGi3702.AT3G25220.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38935.
    SMRiQ38935. Positions 47-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 14089PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi150 – 1534Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    InParanoidiQ38935.
    KOiK09569.
    OMAiCLNEKRI.
    PhylomeDBiQ38935.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q38935-1 [UniParc]FASTAAdd to Basket

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    MMSSASAMKA VGFLLLLTIL TLAYAKKSGD VTELQIGVKY KPQKCDLQAH    50
    KGDKIKVHYR GKLTDGTVFD SSFERGDPIE FELGTGQVIP GWDQGLLGAC 100
    VGEKRKLKIP SKLGYGDNGS PPKIPGGATL IFDTELVAVN GEPSSEAKSK 150
    NEL 153
    Length:153
    Mass (Da):16,355
    Last modified:September 19, 2002 - v2
    Checksum:i09549E647B738CD9
    GO

    Sequence cautioni

    The sequence AAC49390.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAM65589.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721S → I in AAM65589. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52046 mRNA. Translation: AAC49390.1. Different initiation.
    AB026647 Genomic DNA. Translation: BAB02081.1.
    CP002686 Genomic DNA. Translation: AEE76994.1.
    AY062776 mRNA. Translation: AAL32854.1.
    AY128760 mRNA. Translation: AAM91160.1.
    AY088043 mRNA. Translation: AAM65589.1. Different initiation.
    PIRiS71237.
    RefSeqiNP_566762.1. NM_113428.3.
    UniGeneiAt.6372.

    Genome annotation databases

    EnsemblPlantsiAT3G25220.1; AT3G25220.1; AT3G25220.
    GeneIDi822115.
    KEGGiath:AT3G25220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52046 mRNA. Translation: AAC49390.1 . Different initiation.
    AB026647 Genomic DNA. Translation: BAB02081.1 .
    CP002686 Genomic DNA. Translation: AEE76994.1 .
    AY062776 mRNA. Translation: AAL32854.1 .
    AY128760 mRNA. Translation: AAM91160.1 .
    AY088043 mRNA. Translation: AAM65589.1 . Different initiation.
    PIRi S71237.
    RefSeqi NP_566762.1. NM_113428.3.
    UniGenei At.6372.

    3D structure databases

    ProteinModelPortali Q38935.
    SMRi Q38935. Positions 47-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 7446. 5 interactions.
    IntActi Q38935. 7 interactions.
    STRINGi 3702.AT3G25220.1-P.

    Proteomic databases

    PaxDbi Q38935.
    PRIDEi Q38935.

    Protocols and materials databases

    DNASUi 822115.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G25220.1 ; AT3G25220.1 ; AT3G25220 .
    GeneIDi 822115.
    KEGGi ath:AT3G25220.

    Organism-specific databases

    TAIRi AT3G25220.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    InParanoidi Q38935.
    KOi K09569.
    OMAi CLNEKRI.
    PhylomeDBi Q38935.

    Enzyme and pathway databases

    BioCyci ARA:AT3G25220-MONOMER.

    Gene expression databases

    Genevestigatori Q38935.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a FKBP-type immunophilin from higher plants."
      Luan S., Kudla J., Gruissem W., Schreiber S.L.
      Proc. Natl. Acad. Sci. U.S.A. 93:6964-6969(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis."
      He Z., Li L., Luan S.
      Plant Physiol. 134:1248-1267(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiFK151_ARATH
    AccessioniPrimary (citable) accession number: Q38935
    Secondary accession number(s): Q8LA41, Q9LSF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3