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Protein

Lycopene beta cyclase, chloroplastic

Gene

LCY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: beta-zeacarotene biosynthesis

This protein is involved in the pathway beta-zeacarotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-zeacarotene biosynthesis and in Carotenoid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 113NADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT3G10230-MONOMER.
MetaCyc:AT3G10230-MONOMER.
UniPathwayiUPA00802.
UPA00805.

Names & Taxonomyi

Protein namesi
Recommended name:
Lycopene beta cyclase, chloroplastic (EC:5.5.1.19)
Gene namesi
Name:LCY1
Synonyms:LYC
Ordered Locus Names:At3g10230
ORF Names:F14P13.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G10230.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48ChloroplastCombined sourcesAdd BLAST48
ChainiPRO_000001842949 – 501Lycopene beta cyclase, chloroplasticAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N-acetylvalineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38933.

Expressioni

Gene expression databases

GenevisibleiQ38933. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G10230.1.

Structurei

3D structure databases

ProteinModelPortaliQ38933.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lycopene cyclase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IGXM. Eukaryota.
ENOG410XPIY. LUCA.
HOGENOMiHOG000224851.
InParanoidiQ38933.
KOiK06443.
OMAiHRLYQFG.
OrthoDBiEOG0936092S.
PhylomeDBiQ38933.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR010108. Lycopene_cyclase_b/e.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01790. carotene-cycl. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38933-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTLLKTPNK LDFFIPQFHG FERLCSNNPY HSRVRLGVKK RAIKIVSSVV
60 70 80 90 100
SGSAALLDLV PETKKENLDF ELPLYDTSKS QVVDLAIVGG GPAGLAVAQQ
110 120 130 140 150
VSEAGLSVCS IDPSPKLIWP NNYGVWVDEF EAMDLLDCLD TTWSGAVVYV
160 170 180 190 200
DEGVKKDLSR PYGRVNRKQL KSKMLQKCIT NGVKFHQSKV TNVVHEEANS
210 220 230 240 250
TVVCSDGVKI QASVVLDATG FSRCLVQYDK PYNPGYQVAY GIVAEVDGHP
260 270 280 290 300
FDVDKMVFMD WRDKHLDSYP ELKERNSKIP TFLYAMPFSS NRIFLEETSL
310 320 330 340 350
VARPGLRMED IQERMAARLK HLGINVKRIE EDERCVIPMG GPLPVLPQRV
360 370 380 390 400
VGIGGTAGMV HPSTGYMVAR TLAAAPIVAN AIVRYLGSPS SNSLRGDQLS
410 420 430 440 450
AEVWRDLWPI ERRRQREFFC FGMDILLKLD LDATRRFFDA FFDLQPHYWH
460 470 480 490 500
GFLSSRLFLP ELLVFGLSLF SHASNTSRLE IMTKGTVPLA KMINNLVQDR

D
Length:501
Mass (Da):56,177
Last modified:November 1, 1996 - v1
Checksum:iC3014578D0BDC4E2
GO
Isoform 2 (identifier: Q38933-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:369
Mass (Da):41,779
Checksum:i12DC2F1258665128
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31H → P in AAA81880 (Ref. 2) Curated1
Sequence conflicti243V → I in AAA81880 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355461 – 132Missing in isoform 2. CuratedAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50739 mRNA. Translation: AAB53337.1.
L40176 mRNA. Translation: AAA81880.1.
AF117256 Genomic DNA. Translation: AAF82388.1.
AC009400 Genomic DNA. Translation: AAF02819.1.
CP002686 Genomic DNA. Translation: AEE74874.1.
CP002686 Genomic DNA. Translation: AEE74875.1.
AY059749 mRNA. Translation: AAL24097.1.
AY091396 mRNA. Translation: AAM14335.1.
RefSeqiNP_001078131.1. NM_001084662.1. [Q38933-2]
NP_187634.1. NM_111858.2. [Q38933-1]
UniGeneiAt.1532.
At.71154.
At.71830.

Genome annotation databases

EnsemblPlantsiAT3G10230.1; AT3G10230.1; AT3G10230. [Q38933-1]
GeneIDi820185.
GrameneiAT3G10230.1; AT3G10230.1; AT3G10230.
KEGGiath:AT3G10230.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50739 mRNA. Translation: AAB53337.1.
L40176 mRNA. Translation: AAA81880.1.
AF117256 Genomic DNA. Translation: AAF82388.1.
AC009400 Genomic DNA. Translation: AAF02819.1.
CP002686 Genomic DNA. Translation: AEE74874.1.
CP002686 Genomic DNA. Translation: AEE74875.1.
AY059749 mRNA. Translation: AAL24097.1.
AY091396 mRNA. Translation: AAM14335.1.
RefSeqiNP_001078131.1. NM_001084662.1. [Q38933-2]
NP_187634.1. NM_111858.2. [Q38933-1]
UniGeneiAt.1532.
At.71154.
At.71830.

3D structure databases

ProteinModelPortaliQ38933.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10230.1.

Proteomic databases

PaxDbiQ38933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10230.1; AT3G10230.1; AT3G10230. [Q38933-1]
GeneIDi820185.
GrameneiAT3G10230.1; AT3G10230.1; AT3G10230.
KEGGiath:AT3G10230.

Organism-specific databases

TAIRiAT3G10230.

Phylogenomic databases

eggNOGiENOG410IGXM. Eukaryota.
ENOG410XPIY. LUCA.
HOGENOMiHOG000224851.
InParanoidiQ38933.
KOiK06443.
OMAiHRLYQFG.
OrthoDBiEOG0936092S.
PhylomeDBiQ38933.

Enzyme and pathway databases

UniPathwayiUPA00802.
UPA00805.
BioCyciARA:AT3G10230-MONOMER.
MetaCyc:AT3G10230-MONOMER.

Miscellaneous databases

PROiQ38933.

Gene expression databases

GenevisibleiQ38933. AT.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR010108. Lycopene_cyclase_b/e.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01790. carotene-cycl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCYB_ARATH
AccessioniPrimary (citable) accession number: Q38933
Secondary accession number(s): A8MR53, Q39145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.