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Protein

Profilin-4

Gene

PRO4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: TAIR

GO - Biological processi

  • actin cytoskeleton organization Source: TAIR
  • sequestering of actin monomers Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-4
Gene namesi
Name:PRO4
Synonyms:PFN4
Ordered Locus Names:At2g19770
ORF Names:F6F22.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G19770.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • cell cortex Source: GO_Central
  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
  • phragmoplast Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Profilin-4PRO_0000199618Add
BLAST

Proteomic databases

PaxDbiQ38905.
PRIDEiQ38905.

Expressioni

Tissue specificityi

Floral tissues.

Gene expression databases

ExpressionAtlasiQ38905. differential.
GenevisibleiQ38905. AT.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

  • actin monomer binding Source: TAIR

Protein-protein interaction databases

STRINGi3702.AT2G19770.1.

Structurei

3D structure databases

ProteinModelPortaliQ38905.
SMRiQ38905. Positions 2-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
InParanoidiQ38905.
KOiK05759.
OMAiSAFPKFK.
PhylomeDBiQ38905.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDEH LMCDVGDGQG HHLTAAAIIG HDGSVWAQSA NFPQFKPQEI
60 70 80 90 100
TDIMKDFDEP GHLAPTGMFL AGLKYMVIQG EPNAVIRGKK GAGGITIKKT
110 120 130
GQSMVFGLYE EPVTPGQCNM VVERLGDYLI EQGL
Length:134
Mass (Da):14,550
Last modified:November 1, 1997 - v1
Checksum:iD6DB21CFF5DF46EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43324 Genomic DNA. Translation: AAB39479.1.
AC005169 Genomic DNA. Translation: AAC62139.1.
CP002685 Genomic DNA. Translation: AEC06924.1.
AY085645 mRNA. Translation: AAM62866.1.
PIRiH84580.
RefSeqiNP_179567.1. NM_127535.2.
UniGeneiAt.39795.

Genome annotation databases

EnsemblPlantsiAT2G19770.1; AT2G19770.1; AT2G19770.
GeneIDi816496.
GrameneiAT2G19770.1; AT2G19770.1; AT2G19770.
KEGGiath:AT2G19770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43324 Genomic DNA. Translation: AAB39479.1.
AC005169 Genomic DNA. Translation: AAC62139.1.
CP002685 Genomic DNA. Translation: AEC06924.1.
AY085645 mRNA. Translation: AAM62866.1.
PIRiH84580.
RefSeqiNP_179567.1. NM_127535.2.
UniGeneiAt.39795.

3D structure databases

ProteinModelPortaliQ38905.
SMRiQ38905. Positions 2-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G19770.1.

Proteomic databases

PaxDbiQ38905.
PRIDEiQ38905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G19770.1; AT2G19770.1; AT2G19770.
GeneIDi816496.
GrameneiAT2G19770.1; AT2G19770.1; AT2G19770.
KEGGiath:AT2G19770.

Organism-specific databases

TAIRiAT2G19770.

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
InParanoidiQ38905.
KOiK05759.
OMAiSAFPKFK.
PhylomeDBiQ38905.

Miscellaneous databases

PROiQ38905.

Gene expression databases

ExpressionAtlasiQ38905. differential.
GenevisibleiQ38905. AT.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin."
    Christensen H.E.M., Ramachandran S., Tan C.T., Surana U., Dong C.H., Chua N.-H.
    Plant J. 10:269-279(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPROF4_ARATH
AccessioniPrimary (citable) accession number: Q38905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 17, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.