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Protein

Profilin-4

Gene

PRO4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: TAIR

GO - Biological processi

  • actin cytoskeleton organization Source: TAIR
  • sequestering of actin monomers Source: GO_Central

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-4
Gene namesi
Name:PRO4
Synonyms:PFN4
Ordered Locus Names:At2g19770
ORF Names:F6F22.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G19770
TAIRilocus:2051945 AT2G19770

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001996181 – 134Profilin-4Add BLAST134

Proteomic databases

PaxDbiQ38905
PRIDEiQ38905

Expressioni

Tissue specificityi

Floral tissues.

Gene expression databases

ExpressionAtlasiQ38905 baseline and differential
GenevisibleiQ38905 AT

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

  • actin monomer binding Source: TAIR

Protein-protein interaction databases

STRINGi3702.AT2G19770.1

Structurei

3D structure databases

ProteinModelPortaliQ38905
SMRiQ38905
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755 Eukaryota
ENOG41126PD LUCA
InParanoidiQ38905
KOiK05759
OMAiENTDIMK
OrthoDBiEOG09360WEB
PhylomeDBiQ38905

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
IPR027310 Profilin_CS
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414 PROFILIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q38905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDEH LMCDVGDGQG HHLTAAAIIG HDGSVWAQSA NFPQFKPQEI
60 70 80 90 100
TDIMKDFDEP GHLAPTGMFL AGLKYMVIQG EPNAVIRGKK GAGGITIKKT
110 120 130
GQSMVFGLYE EPVTPGQCNM VVERLGDYLI EQGL
Length:134
Mass (Da):14,550
Last modified:November 1, 1997 - v1
Checksum:iD6DB21CFF5DF46EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43324 Genomic DNA Translation: AAB39479.1
AC005169 Genomic DNA Translation: AAC62139.1
CP002685 Genomic DNA Translation: AEC06924.1
AY085645 mRNA Translation: AAM62866.1
PIRiH84580
RefSeqiNP_179567.1, NM_127535.3
UniGeneiAt.39795

Genome annotation databases

EnsemblPlantsiAT2G19770.1; AT2G19770.1; AT2G19770
GeneIDi816496
GrameneiAT2G19770.1; AT2G19770.1; AT2G19770
KEGGiath:AT2G19770

Similar proteinsi

Entry informationi

Entry nameiPROF4_ARATH
AccessioniPrimary (citable) accession number: Q38905
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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