Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase CYP19-1

Gene

CYP19-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in reactive oxygen species production in response to pathogen infection.1 Publication

Caution

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity).By similarity

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • signal transduction Source: TAIR

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP19-1 (EC:5.2.1.8)
Short name:
PPIase CYP19-1
Alternative name(s):
Cyclophilin of 19 kDa 1
Rotamase cyclophilin-3
Gene namesi
Name:CYP19-1
Synonyms:ROC3
Ordered Locus Names:At2g16600
ORF Names:T24I21.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G16600
TAIRilocus:2045076 AT2G16600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increased susceptibility to P.syringae infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641351 – 173Peptidyl-prolyl cis-trans isomerase CYP19-1Add BLAST173

Proteomic databases

PaxDbiQ38900
PRIDEiQ38900

PTM databases

iPTMnetiQ38900

Expressioni

Tissue specificityi

Pollen (at protein level). Ubiquitous with higher levels in stems and flowers. In seeds, present in endosperm and embryo.4 Publications

Inductioni

Up-regulated by light, wounding and pathogen infection.2 Publications

Gene expression databases

ExpressionAtlasiQ38900 baseline and differential
GenevisibleiQ38900 AT

Interactioni

Protein-protein interaction databases

BioGridi15185 interactors.
IntActiQ38900 2 interactors.
STRINGi3702.AT2G16600.1

Structurei

3D structure databases

ProteinModelPortaliQ38900
SMRiQ38900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 171PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
HOGENOMiHOG000065981
InParanoidiQ38900
KOiK01802
OMAiEPFAVSK
OrthoDBiEOG09360PV0
PhylomeDBiQ38900

Family and domain databases

Gene3Di2.40.100.101 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38900-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNPKVYFD MTVGGKSAGR IVMELYADTT PETAENFRAL CTGERGIGKQ
60 70 80 90 100
GKPLHYKGSS FHRVIPKFMC QGGDFTAGNG TGGESIYGSK FKDENFIKKH
110 120 130 140 150
TGPGILSMAN AGANTNGSQF FICTEKTSWL DGKHVVFGQV VEGLNVVRDI
160 170
EKVGSDSGRT SKPVVIADCG QIS
Length:173
Mass (Da):18,492
Last modified:November 1, 1996 - v1
Checksum:i9D292651B005F492
GO
Isoform 2 (identifier: Q38900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-72: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:151
Mass (Da):15,992
Checksum:i80ACF695A0F03F09
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05538551 – 72Missing in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40399 mRNA Translation: AAB96832.1
AC005825 Genomic DNA Translation: AAD24594.1
CP002685 Genomic DNA Translation: AEC06517.1
CP002685 Genomic DNA Translation: AEC06518.1
AY048215 mRNA Translation: AAK82478.1
AY091694 mRNA Translation: AAM10293.1
AY086330 mRNA Translation: AAM64399.1
PIRiS71219
RefSeqiNP_001077901.1, NM_001084432.1 [Q38900-2]
NP_001318231.1, NM_001335481.1 [Q38900-1]
UniGeneiAt.22516
At.24328
At.67816

Genome annotation databases

EnsemblPlantsiAT2G16600.1; AT2G16600.1; AT2G16600 [Q38900-1]
AT2G16600.2; AT2G16600.2; AT2G16600 [Q38900-2]
GeneIDi816161
GrameneiAT2G16600.1; AT2G16600.1; AT2G16600 [Q38900-1]
AT2G16600.2; AT2G16600.2; AT2G16600 [Q38900-2]
KEGGiath:AT2G16600

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCP19A_ARATH
AccessioniPrimary (citable) accession number: Q38900
Secondary accession number(s): F4IL99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome