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Protein

Peptidyl-prolyl cis-trans isomerase CYP19-1

Gene

CYP19-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in reactive oxygen species production in response to pathogen infection.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity).By similarity

GO - Molecular functioni

  • peptide binding Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • signal transduction Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

ReactomeiR-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP19-1 (EC:5.2.1.8)
Short name:
PPIase CYP19-1
Alternative name(s):
Cyclophilin of 19 kDa 1
Rotamase cyclophilin-3
Gene namesi
Name:CYP19-1
Synonyms:ROC3
Ordered Locus Names:At2g16600
ORF Names:T24I21.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G16600.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increased susceptibility to P.syringae infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641351 – 173Peptidyl-prolyl cis-trans isomerase CYP19-1Add BLAST173

Proteomic databases

PaxDbiQ38900.
PRIDEiQ38900.

PTM databases

iPTMnetiQ38900.

Expressioni

Tissue specificityi

Pollen (at protein level). Ubiquitous with higher levels in stems and flowers. In seeds, present in endosperm and embryo.4 Publications

Inductioni

Up-regulated by light, wounding and pathogen infection.2 Publications

Gene expression databases

ExpressionAtlasiQ38900. baseline and differential.
GenevisibleiQ38900. AT.

Interactioni

Protein-protein interaction databases

BioGridi1518. 5 interactors.
IntActiQ38900. 2 interactors.
MINTiMINT-8064090.
STRINGi3702.AT2G16600.1.

Structurei

3D structure databases

ProteinModelPortaliQ38900.
SMRiQ38900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 171PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ38900.
OMAiHFRYKSA.
OrthoDBiEOG09360PV0.
PhylomeDBiQ38900.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38900-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNPKVYFD MTVGGKSAGR IVMELYADTT PETAENFRAL CTGERGIGKQ
60 70 80 90 100
GKPLHYKGSS FHRVIPKFMC QGGDFTAGNG TGGESIYGSK FKDENFIKKH
110 120 130 140 150
TGPGILSMAN AGANTNGSQF FICTEKTSWL DGKHVVFGQV VEGLNVVRDI
160 170
EKVGSDSGRT SKPVVIADCG QIS
Length:173
Mass (Da):18,492
Last modified:November 1, 1996 - v1
Checksum:i9D292651B005F492
GO
Isoform 2 (identifier: Q38900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-72: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:151
Mass (Da):15,992
Checksum:i80ACF695A0F03F09
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05538551 – 72Missing in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40399 mRNA. Translation: AAB96832.1.
AC005825 Genomic DNA. Translation: AAD24594.1.
CP002685 Genomic DNA. Translation: AEC06517.1.
CP002685 Genomic DNA. Translation: AEC06518.1.
AY048215 mRNA. Translation: AAK82478.1.
AY091694 mRNA. Translation: AAM10293.1.
AY086330 mRNA. Translation: AAM64399.1.
PIRiS71219.
RefSeqiNP_001077901.1. NM_001084432.1. [Q38900-2]
UniGeneiAt.22516.
At.24328.
At.67816.

Genome annotation databases

EnsemblPlantsiAT2G16600.1; AT2G16600.1; AT2G16600. [Q38900-1]
AT2G16600.2; AT2G16600.2; AT2G16600. [Q38900-2]
GeneIDi816161.
GrameneiAT2G16600.1; AT2G16600.1; AT2G16600.
AT2G16600.2; AT2G16600.2; AT2G16600.
KEGGiath:AT2G16600.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40399 mRNA. Translation: AAB96832.1.
AC005825 Genomic DNA. Translation: AAD24594.1.
CP002685 Genomic DNA. Translation: AEC06517.1.
CP002685 Genomic DNA. Translation: AEC06518.1.
AY048215 mRNA. Translation: AAK82478.1.
AY091694 mRNA. Translation: AAM10293.1.
AY086330 mRNA. Translation: AAM64399.1.
PIRiS71219.
RefSeqiNP_001077901.1. NM_001084432.1. [Q38900-2]
UniGeneiAt.22516.
At.24328.
At.67816.

3D structure databases

ProteinModelPortaliQ38900.
SMRiQ38900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1518. 5 interactors.
IntActiQ38900. 2 interactors.
MINTiMINT-8064090.
STRINGi3702.AT2G16600.1.

PTM databases

iPTMnetiQ38900.

Proteomic databases

PaxDbiQ38900.
PRIDEiQ38900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G16600.1; AT2G16600.1; AT2G16600. [Q38900-1]
AT2G16600.2; AT2G16600.2; AT2G16600. [Q38900-2]
GeneIDi816161.
GrameneiAT2G16600.1; AT2G16600.1; AT2G16600.
AT2G16600.2; AT2G16600.2; AT2G16600.
KEGGiath:AT2G16600.

Organism-specific databases

TAIRiAT2G16600.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ38900.
OMAiHFRYKSA.
OrthoDBiEOG09360PV0.
PhylomeDBiQ38900.

Enzyme and pathway databases

ReactomeiR-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ38900.

Gene expression databases

ExpressionAtlasiQ38900. baseline and differential.
GenevisibleiQ38900. AT.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP19A_ARATH
AccessioniPrimary (citable) accession number: Q38900
Secondary accession number(s): F4IL99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.