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Protein

Glycogen synthase kinase 3

Gene

GSK3

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Was identified as a drug target for the treatment of African sleeping sickness. RNA interference leads to growth arrest and altered parasite morphology, demonstrating requirement for cell survival.1 Publication

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

Kineticsi

  1. KM=4.5 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei49ATPPROSITE-ProRule annotationBy similarity1
    Active sitei152Proton acceptorPROSITE-ProRule annotationBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotationBy similarity9

    GO - Molecular functioni

    GO - Biological processi

    • growth Source: GeneDB
    • protein phosphorylation Source: UniProtKB

    Keywordsi

    Molecular functionKinase, Serine/threonine-protein kinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen synthase kinase 31 Publication (EC:2.7.11.26)
    Short name:
    GSK-3 short1 Publication
    Gene namesi
    Name:GSK31 Publication
    ORF Names:Tb927.10.13780
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
    Taxonomic identifieri185431 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    Proteomesi
    • UP000008524 Componenti: Chromosome 10

    Organism-specific databases

    EuPathDBiTriTrypDB:Tb927.10.13780

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003938641 – 352Glycogen synthase kinase 3Add BLAST352

    Proteomic databases

    PaxDbiQ388M1

    Interactioni

    Subunit structurei

    Inhibited by cyclin kinase 2 (CDK2) inhibitors, including GW8510.1 Publication

    Protein-protein interaction databases

    STRINGi5691.EAN78749

    Structurei

    3D structure databases

    ProteinModelPortaliQ388M1
    SMRiQ388M1
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini20 – 310Protein kinasePROSITE-ProRule annotationAdd BLAST291

    Sequence similaritiesi

    Phylogenomic databases

    InParanoidiQ388M1
    KOiK00870
    OMAiYSNGDKK

    Family and domain databases

    InterProiView protein in InterPro
    IPR011009 Kinase-like_dom_sf
    IPR000719 Prot_kinase_dom
    IPR008271 Ser/Thr_kinase_AS
    PfamiView protein in Pfam
    PF00069 Pkinase, 1 hit
    SMARTiView protein in SMART
    SM00220 S_TKc, 1 hit
    SUPFAMiSSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS00108 PROTEIN_KINASE_ST, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q388M1-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MSLNLTDAAD DRSYKEMEKY TVERVAGQGT FGTVQLARDK STGSLVAIKK
    60 70 80 90 100
    VIQDPRFKNR ELQIMQHLAR LRHPNIVMLK NYFYTVGGEG RRNDVYLNVV
    110 120 130 140 150
    MEFVPETLHR TCRNYYRRMT NPPLILVKVF MFQLLRSIAC LHIPVINICH
    160 170 180 190 200
    RDIKPHNVLV DEQTGELKLC DFGSAKRLAA DEPNVAYICS RYYRAPELIF
    210 220 230 240 250
    GNQFYTTAVD IWSVGCIFAE MLLGEPIFCG ENTSGQLREI VKILGKPTKE
    260 270 280 290 300
    ELHKLNGSST EINANAKATP WENVFKQPLP AEVYDLCGKI FKYVPDQRIT
    310 320 330 340 350
    PLDALCHPFF NELREPTTKL PSGNPLPAHL YQFTPDEVEA MTEAQREYLL

    KK
    Length:352
    Mass (Da):40,321
    Last modified:November 22, 2005 - v1
    Checksum:i7613B9C53B119A4B
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CM000208 Genomic DNA Translation: EAN78749.1
    RefSeqiXP_827861.1, XM_822768.1

    Genome annotation databases

    GeneDBiTb927.10.13780:pep
    GeneIDi3661993
    KEGGitbr:Tb10.61.3140

    Similar proteinsi

    Entry informationi

    Entry nameiGSK3B_TRYB2
    AccessioniPrimary (citable) accession number: Q388M1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: November 22, 2005
    Last modified: April 25, 2018
    This is version 80 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health