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Q388M1

- GSK3B_TRYB2

UniProt

Q388M1 - GSK3B_TRYB2

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Protein

Glycogen synthase kinase 3

Gene

GSK3

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

Kineticsi

  1. KM=4.5 µM for ATP1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPBy similarityPROSITE-ProRule annotation
Active sitei152 – 1521Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: GeneDB_Tbrucei
  2. protein serine/threonine kinase activity Source: GeneDB_Tbrucei
  3. tau-protein kinase activity Source: UniProtKB

GO - Biological processi

  1. growth Source: GeneDB_Tbrucei
  2. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase kinase 31 Publication (EC:2.7.11.26)
Short name:
GSK-3 short1 Publication
Gene namesi
Name:GSK31 Publication
ORF Names:Tb927.10.13780
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Glycogen synthase kinase 3PRO_0000393864Add
BLAST

Interactioni

Subunit structurei

Inhibited by cyclin kinase 2 (CDK2) inhibitors, including GW8510.1 Publication

Protein-protein interaction databases

STRINGi5691.Tb10.61.3140.

Structurei

3D structure databases

ProteinModelPortaliQ388M1.
SMRiQ388M1. Positions 18-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 310291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ388M1.
KOiK00870.
OMAiFGNLKLP.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q388M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLNLTDAAD DRSYKEMEKY TVERVAGQGT FGTVQLARDK STGSLVAIKK
60 70 80 90 100
VIQDPRFKNR ELQIMQHLAR LRHPNIVMLK NYFYTVGGEG RRNDVYLNVV
110 120 130 140 150
MEFVPETLHR TCRNYYRRMT NPPLILVKVF MFQLLRSIAC LHIPVINICH
160 170 180 190 200
RDIKPHNVLV DEQTGELKLC DFGSAKRLAA DEPNVAYICS RYYRAPELIF
210 220 230 240 250
GNQFYTTAVD IWSVGCIFAE MLLGEPIFCG ENTSGQLREI VKILGKPTKE
260 270 280 290 300
ELHKLNGSST EINANAKATP WENVFKQPLP AEVYDLCGKI FKYVPDQRIT
310 320 330 340 350
PLDALCHPFF NELREPTTKL PSGNPLPAHL YQFTPDEVEA MTEAQREYLL

KK
Length:352
Mass (Da):40,321
Last modified:November 22, 2005 - v1
Checksum:i7613B9C53B119A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN78749.1.
RefSeqiXP_827861.1. XM_822768.1.

Genome annotation databases

GeneIDi3661993.
KEGGitbr:Tb10.61.3140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000208 Genomic DNA. Translation: EAN78749.1 .
RefSeqi XP_827861.1. XM_822768.1.

3D structure databases

ProteinModelPortali Q388M1.
SMRi Q388M1. Positions 18-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5691.Tb10.61.3140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3661993.
KEGGi tbr:Tb10.61.3140.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q388M1.
KOi K00870.
OMAi FGNLKLP.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1.
  2. Cited for: CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INHIBITION BY DRUGS, IDENTIFICATION AS A DRUG TARGET.
    Strain: 427.

Entry informationi

Entry nameiGSK3B_TRYB2
AccessioniPrimary (citable) accession number: Q388M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Was identified as a drug target for the treatment of African sleeping sickness. RNA interference leads to growth arrest and altered parasite morphology, demonstrating requirement for cell survival.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3