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Protein

Homeobox protein BEL1 homolog

Gene

BEL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules (PubMed:22786869).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi391 – 453HomeoboxPROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BEL1 homolog
Gene namesi
Name:BEL1
Synonyms:BELL1
Ordered Locus Names:At5g41410
ORF Names:MYC6.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G41410
TAIRilocus:2177856 AT5G41410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003154561 – 611Homeobox protein BEL1 homologAdd BLAST611

Proteomic databases

PaxDbiQ38897

PTM databases

iPTMnetiQ38897

Expressioni

Tissue specificityi

Expressed in both floral and vegetative tissues.1 Publication

Developmental stagei

Early expression is detected in the inflorescence apex of developing flowers and also in the ovule primordium and the integuments.1 Publication

Gene expression databases

ExpressionAtlasiQ38897 baseline and differential
GenevisibleiQ38897 AT

Interactioni

Subunit structurei

May form heterodimeric complexes with TALE/KNOX proteins STM, KNAT1/BP, KNAT2 and KNAT5 (PubMed:17873098). Interacts with AG-SEP1 and AG-SEP3 dimers (PubMed:17693535). Interacts with KNATM, isoform KNATM-B (PubMed:18398054).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi19394, 18 interactors
IntActiQ38897, 31 interactors
STRINGi3702.AT5G41410.1

Structurei

3D structure databases

ProteinModelPortaliQ38897
SMRiQ38897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 213SR/KY domainAdd BLAST17
Regioni269 – 340BELL domainAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi275 – 290Bipartite nuclear localizationSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 77His-richAdd BLAST69
Compositional biasi144 – 149Poly-Gln6
Compositional biasi167 – 172Poly-Met6
Compositional biasi178 – 183Poly-Asn6

Domaini

The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.

Sequence similaritiesi

Belongs to the TALE/BELL homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOGENOMiHOG000239679
InParanoidiQ38897
OMAiGHYREQM
OrthoDBiEOG093609BS
PhylomeDBiQ38897

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR006563 POX_dom
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF07526 POX, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00574 POX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q38897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDQFYGHN NHHHQEQQHQ MINQIQGFDE TNQNPTDHHH YNHQIFGSNS
60 70 80 90 100
NMGMMIDFSK QQQIRMTSGS DHHHHHHQTS GGTDQNQLLE DSSSAMRLCN
110 120 130 140 150
VNNDFPSEVN DERPPQRPSQ GLSLSLSSSN PTSISLQSFE LRPQQQQQQG
160 170 180 190 200
YSGNKSTQHQ NLQHTQMMMM MMNSHHQNNN NNNHQHHNHH QFQIGSSKYL
210 220 230 240 250
SPAQELLSEF CSLGVKESDE EVMMMKHKKK QKGKQQEEWD TSHHSNNDQH
260 270 280 290 300
DQSATTSSKK HVPPLHSLEF MELQKRKAKL LSMLEELKRR YGHYREQMRV
310 320 330 340 350
AAAAFEAAVG LGGAEIYTAL ASRAMSRHFR CLKDGLVGQI QATSQALGER
360 370 380 390 400
EEDNRAVSIA ARGETPRLRL LDQALRQQKS YRQMTLVDAH PWRPQRGLPE
410 420 430 440 450
RAVTTLRAWL FEHFLHPYPS DVDKHILARQ TGLSRSQVSN WFINARVRLW
460 470 480 490 500
KPMIEEMYCE ETRSEQMEIT NPMMIDTKPD PDQLIRVEPE SLSSIVTNPT
510 520 530 540 550
SKSGHNSTHG TMSLGSTFDF SLYGNQAVTY AGEGGPRGDV SLTLGLQRND
560 570 580 590 600
GNGGVSLALS PVTAQGGQLF YGRDHIEEGP VQYSASMLDD DQVQNLPYRN
610
LMGAQLLHDI V
Length:611
Mass (Da):69,493
Last modified:June 1, 2003 - v2
Checksum:i6C885F0B366739AD
GO

Sequence cautioni

The sequence AAK96704 differs from that shown. Reason: Frameshift at position 513.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113R → G in AAK96704 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39944 mRNA Translation: AAB05099.2
AB006707 Genomic DNA Translation: BAB08513.1
CP002688 Genomic DNA Translation: AED94676.1
AY049237 mRNA Translation: AAK83580.1
AY054513 mRNA Translation: AAK96704.1 Frameshift.
BT002637 mRNA Translation: AAO11553.1
PIRiA57632
RefSeqiNP_198957.1, NM_123506.3
UniGeneiAt.24568

Genome annotation databases

EnsemblPlantsiAT5G41410.1; AT5G41410.1; AT5G41410
GeneIDi834143
GrameneiAT5G41410.1; AT5G41410.1; AT5G41410
KEGGiath:AT5G41410

Similar proteinsi

Entry informationi

Entry nameiBEL1_ARATH
AccessioniPrimary (citable) accession number: Q38897
Secondary accession number(s): Q93Y33, Q9FN59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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