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Protein

Homeobox protein BEL1 homolog

Gene

BEL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules (PubMed:22786869).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi391 – 453HomeoboxPROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BEL1 homolog
Gene namesi
Name:BEL1
Synonyms:BELL1
Ordered Locus Names:At5g41410
ORF Names:MYC6.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G41410.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nucleus Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003154561 – 611Homeobox protein BEL1 homologAdd BLAST611

Proteomic databases

PaxDbiQ38897.

PTM databases

iPTMnetiQ38897.

Expressioni

Tissue specificityi

Expressed in both floral and vegetative tissues.1 Publication

Developmental stagei

Early expression is detected in the inflorescence apex of developing flowers and also in the ovule primordium and the integuments.1 Publication

Gene expression databases

GenevisibleiQ38897. AT.

Interactioni

Subunit structurei

May form heterodimeric complexes with TALE/KNOX proteins STM, KNAT1/BP, KNAT2 and KNAT5 (PubMed:17873098). Interacts with AG-SEP1 and AG-SEP3 dimers (PubMed:17693535). Interacts with KNATM, isoform KNATM-B (PubMed:18398054).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KNAT1P466396EBI-1153783,EBI-530486
KNAT2P466403EBI-1153783,EBI-1153809
KNAT3P480003EBI-1153783,EBI-1153908
KNAT5P480023EBI-1153783,EBI-1153922
STMQ388746EBI-1153783,EBI-530523

Protein-protein interaction databases

BioGridi19394. 18 interactors.
IntActiQ38897. 18 interactors.
STRINGi3702.AT5G41410.1.

Structurei

3D structure databases

ProteinModelPortaliQ38897.
SMRiQ38897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 213SR/KY domainAdd BLAST17
Regioni269 – 340BELL domainAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi275 – 290Bipartite nuclear localizationSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 77His-richAdd BLAST69
Compositional biasi144 – 149Poly-Gln6
Compositional biasi167 – 172Poly-Met6
Compositional biasi178 – 183Poly-Asn6

Domaini

The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.

Sequence similaritiesi

Belongs to the TALE/BELL homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000239679.
InParanoidiQ38897.
OMAiMEITNPM.
OrthoDBiEOG093609BS.
PhylomeDBiQ38897.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDQFYGHN NHHHQEQQHQ MINQIQGFDE TNQNPTDHHH YNHQIFGSNS
60 70 80 90 100
NMGMMIDFSK QQQIRMTSGS DHHHHHHQTS GGTDQNQLLE DSSSAMRLCN
110 120 130 140 150
VNNDFPSEVN DERPPQRPSQ GLSLSLSSSN PTSISLQSFE LRPQQQQQQG
160 170 180 190 200
YSGNKSTQHQ NLQHTQMMMM MMNSHHQNNN NNNHQHHNHH QFQIGSSKYL
210 220 230 240 250
SPAQELLSEF CSLGVKESDE EVMMMKHKKK QKGKQQEEWD TSHHSNNDQH
260 270 280 290 300
DQSATTSSKK HVPPLHSLEF MELQKRKAKL LSMLEELKRR YGHYREQMRV
310 320 330 340 350
AAAAFEAAVG LGGAEIYTAL ASRAMSRHFR CLKDGLVGQI QATSQALGER
360 370 380 390 400
EEDNRAVSIA ARGETPRLRL LDQALRQQKS YRQMTLVDAH PWRPQRGLPE
410 420 430 440 450
RAVTTLRAWL FEHFLHPYPS DVDKHILARQ TGLSRSQVSN WFINARVRLW
460 470 480 490 500
KPMIEEMYCE ETRSEQMEIT NPMMIDTKPD PDQLIRVEPE SLSSIVTNPT
510 520 530 540 550
SKSGHNSTHG TMSLGSTFDF SLYGNQAVTY AGEGGPRGDV SLTLGLQRND
560 570 580 590 600
GNGGVSLALS PVTAQGGQLF YGRDHIEEGP VQYSASMLDD DQVQNLPYRN
610
LMGAQLLHDI V
Length:611
Mass (Da):69,493
Last modified:June 1, 2003 - v2
Checksum:i6C885F0B366739AD
GO

Sequence cautioni

The sequence AAK96704 differs from that shown. Reason: Frameshift at position 513.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113R → G in AAK96704 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39944 mRNA. Translation: AAB05099.2.
AB006707 Genomic DNA. Translation: BAB08513.1.
CP002688 Genomic DNA. Translation: AED94676.1.
AY049237 mRNA. Translation: AAK83580.1.
AY054513 mRNA. Translation: AAK96704.1. Frameshift.
BT002637 mRNA. Translation: AAO11553.1.
PIRiA57632.
RefSeqiNP_198957.1. NM_123506.3.
UniGeneiAt.24568.

Genome annotation databases

EnsemblPlantsiAT5G41410.1; AT5G41410.1; AT5G41410.
GeneIDi834143.
GrameneiAT5G41410.1; AT5G41410.1; AT5G41410.
KEGGiath:AT5G41410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39944 mRNA. Translation: AAB05099.2.
AB006707 Genomic DNA. Translation: BAB08513.1.
CP002688 Genomic DNA. Translation: AED94676.1.
AY049237 mRNA. Translation: AAK83580.1.
AY054513 mRNA. Translation: AAK96704.1. Frameshift.
BT002637 mRNA. Translation: AAO11553.1.
PIRiA57632.
RefSeqiNP_198957.1. NM_123506.3.
UniGeneiAt.24568.

3D structure databases

ProteinModelPortaliQ38897.
SMRiQ38897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi19394. 18 interactors.
IntActiQ38897. 18 interactors.
STRINGi3702.AT5G41410.1.

PTM databases

iPTMnetiQ38897.

Proteomic databases

PaxDbiQ38897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G41410.1; AT5G41410.1; AT5G41410.
GeneIDi834143.
GrameneiAT5G41410.1; AT5G41410.1; AT5G41410.
KEGGiath:AT5G41410.

Organism-specific databases

TAIRiAT5G41410.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000239679.
InParanoidiQ38897.
OMAiMEITNPM.
OrthoDBiEOG093609BS.
PhylomeDBiQ38897.

Miscellaneous databases

PROiQ38897.

Gene expression databases

GenevisibleiQ38897. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBEL1_ARATH
AccessioniPrimary (citable) accession number: Q38897
Secondary accession number(s): Q93Y33, Q9FN59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.