Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional regulator SUPERMAN

Gene

SUP

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator considered as cadastral protein that acts indirectly to prevent the B class homeotic proteins APETALA3 and perhaps PISTILLATA from acting in the gynoecial whorl. Principal function is to balance cell proliferation in the third and fourth whorls of developing flowers thereby maintaining the boundary between stamens and carpels. May fulfill this role by repressing genes implicated in cell division. Plays equally a role in the determinacy of the floral meristem. Is also required for normal ovule development.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: TAIR
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • flower development Source: TAIR
  • formation of plant organ boundary Source: TAIR
  • hormone-mediated signaling pathway Source: TAIR
  • regulation of cell proliferation Source: TAIR
  • regulation of cell size Source: TAIR
  • specification of floral organ identity Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Flowering, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator SUPERMAN
Gene namesi
Name:SUP
Synonyms:FLO10
Ordered Locus Names:At3g23130
ORF Names:K14B15.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G23130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63G → D in sup-3. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000478391 – 204Transcriptional regulator SUPERMANAdd BLAST204

Proteomic databases

PaxDbiQ38895.

Expressioni

Tissue specificityi

Expressed early in the third whorl, and later becomes localized at the boundary between the stamen and carpel whorls. Also detected in developing ovule primordia.

Inductioni

Repressed by KRYPTONITE/SUVH4, member of the histone H3-K9 methyltransferase family that contributes with other factors to the CpNpG methylation of the SUP gene resulting in its silencing. The alternative epigenetic states of the SUPERMAN locus have been called Clark Kent alleles. Positively regulated at an early stage of development by LEAFY and by B class homeotic proteins APETALA3 and PISTILLATA. Later expression is maintained by both the B class homeotic proteins and the C class homeotic protein AGAMOUS. These two steps of regulation require the intervention of additional factors.1 Publication

Gene expression databases

ExpressionAtlasiQ38895. baseline and differential.
GenevisibleiQ38895. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G23130.1.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 48Combined sources5
Turni50 – 52Combined sources3
Beta strandi55 – 58Combined sources4
Helixi59 – 67Combined sources9
Turni74 – 77Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NJQNMR-A42-78[»]
2L1ONMR-A42-78[»]
ProteinModelPortaliQ38895.
SMRiQ38895.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ38895.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 204Leucine-zipper-likeAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi195 – 199EAR-like (transcriptional repression)5

Domaini

Contains two overlapping leucine-zipper-like motifs at the C-terminal region, which might serve as a site for protein-protein interaction. In this domain, a slightly degenerated ERF-associated amphiphilic repression (EAR) motif seems to be involved in the activity of transcriptional repression.

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J435. Eukaryota.
ENOG410Z0H6. LUCA.
HOGENOMiHOG000240643.
InParanoidiQ38895.
OMAiSHEMKNG.
OrthoDBiEOG09360UDE.
PhylomeDBiQ38895.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSNSIELR NSFYGRARTS PWSYGDYDNC QQDHDYLLGF SWPPRSYTCS
60 70 80 90 100
FCKREFRSAQ ALGGHMNVHR RDRARLRLQQ SPSSSSTPSP PYPNPNYSYS
110 120 130 140 150
TMANSPPPHH SPLTLFPTLS PPSSPRYRAG LIRSLSPKSK HTPENACKTK
160 170 180 190 200
KSSLLVEAGE ATRFTSKDAC KILRNDEIIS LELEIGLINE SEQDLDLELR

LGFA
Length:204
Mass (Da):23,084
Last modified:November 1, 1996 - v1
Checksum:i2CF36E29A821F76E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38946 Genomic DNA. Translation: AAC49116.1.
AB025608 Genomic DNA. Translation: BAA95724.1.
CP002686 Genomic DNA. Translation: AEE76721.1.
DQ056605 mRNA. Translation: AAY78753.1.
PIRiS60325.
RefSeqiNP_188954.1. NM_113214.2.
UniGeneiAt.53448.

Genome annotation databases

EnsemblPlantsiAT3G23130.1; AT3G23130.1; AT3G23130.
GeneIDi821888.
GrameneiAT3G23130.1; AT3G23130.1; AT3G23130.
KEGGiath:AT3G23130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38946 Genomic DNA. Translation: AAC49116.1.
AB025608 Genomic DNA. Translation: BAA95724.1.
CP002686 Genomic DNA. Translation: AEE76721.1.
DQ056605 mRNA. Translation: AAY78753.1.
PIRiS60325.
RefSeqiNP_188954.1. NM_113214.2.
UniGeneiAt.53448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NJQNMR-A42-78[»]
2L1ONMR-A42-78[»]
ProteinModelPortaliQ38895.
SMRiQ38895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G23130.1.

Proteomic databases

PaxDbiQ38895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G23130.1; AT3G23130.1; AT3G23130.
GeneIDi821888.
GrameneiAT3G23130.1; AT3G23130.1; AT3G23130.
KEGGiath:AT3G23130.

Organism-specific databases

TAIRiAT3G23130.

Phylogenomic databases

eggNOGiENOG410J435. Eukaryota.
ENOG410Z0H6. LUCA.
HOGENOMiHOG000240643.
InParanoidiQ38895.
OMAiSHEMKNG.
OrthoDBiEOG09360UDE.
PhylomeDBiQ38895.

Miscellaneous databases

EvolutionaryTraceiQ38895.
PROiQ38895.

Gene expression databases

ExpressionAtlasiQ38895. baseline and differential.
GenevisibleiQ38895. AT.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUP_ARATH
AccessioniPrimary (citable) accession number: Q38895
Secondary accession number(s): Q4PSN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutations in SUP cause the ectopic expression of APETALA3 leading to the development of extra stamens at the expense of the central carpels of the flower.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.