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Protein

Transcriptional regulator SUPERMAN

Gene

SUP

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator considered as cadastral protein that acts indirectly to prevent the B class homeotic proteins APETALA3 and perhaps PISTILLATA from acting in the gynoecial whorl. Principal function is to balance cell proliferation in the third and fourth whorls of developing flowers thereby maintaining the boundary between stamens and carpels. May fulfill this role by repressing genes implicated in cell division. Plays equally a role in the determinacy of the floral meristem. Is also required for normal ovule development.5 Publications

Miscellaneous

Mutations in SUP cause the ectopic expression of APETALA3 leading to the development of extra stamens at the expense of the central carpels of the flower.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • flower development Source: TAIR
  • formation of plant organ boundary Source: TAIR
  • hormone-mediated signaling pathway Source: TAIR
  • regulation of cell proliferation Source: TAIR
  • regulation of cell size Source: TAIR
  • specification of floral organ identity Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Flowering, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator SUPERMAN
Gene namesi
Name:SUP
Synonyms:FLO10
Ordered Locus Names:At3g23130
ORF Names:K14B15.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G23130
TAIRilocus:2086268 AT3G23130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63G → D in sup-3. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000478391 – 204Transcriptional regulator SUPERMANAdd BLAST204

Proteomic databases

PaxDbiQ38895

Expressioni

Tissue specificityi

Expressed early in the third whorl, and later becomes localized at the boundary between the stamen and carpel whorls. Also detected in developing ovule primordia.

Inductioni

Repressed by KRYPTONITE/SUVH4, member of the histone H3-K9 methyltransferase family that contributes with other factors to the CpNpG methylation of the SUP gene resulting in its silencing. The alternative epigenetic states of the SUPERMAN locus have been called Clark Kent alleles. Positively regulated at an early stage of development by LEAFY and by B class homeotic proteins APETALA3 and PISTILLATA. Later expression is maintained by both the B class homeotic proteins and the C class homeotic protein AGAMOUS. These two steps of regulation require the intervention of additional factors.1 Publication

Gene expression databases

ExpressionAtlasiQ38895 baseline and differential
GenevisibleiQ38895 AT

Interactioni

Protein-protein interaction databases

IntActiQ38895, 10 interactors
STRINGi3702.AT3G23130.1

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 48Combined sources5
Turni50 – 52Combined sources3
Beta strandi55 – 58Combined sources4
Helixi59 – 67Combined sources9
Turni74 – 77Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NJQNMR-A42-78[»]
2L1ONMR-A42-78[»]
ProteinModelPortaliQ38895
SMRiQ38895
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ38895

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 204Leucine-zipper-likeAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi195 – 199EAR-like (transcriptional repression)5

Domaini

Contains two overlapping leucine-zipper-like motifs at the C-terminal region, which might serve as a site for protein-protein interaction. In this domain, a slightly degenerated ERF-associated amphiphilic repression (EAR) motif seems to be involved in the activity of transcriptional repression.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J435 Eukaryota
ENOG410Z0H6 LUCA
HOGENOMiHOG000240643
InParanoidiQ38895
OMAiPENTCET
OrthoDBiEOG09360UDE
PhylomeDBiQ38895

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q38895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSNSIELR NSFYGRARTS PWSYGDYDNC QQDHDYLLGF SWPPRSYTCS
60 70 80 90 100
FCKREFRSAQ ALGGHMNVHR RDRARLRLQQ SPSSSSTPSP PYPNPNYSYS
110 120 130 140 150
TMANSPPPHH SPLTLFPTLS PPSSPRYRAG LIRSLSPKSK HTPENACKTK
160 170 180 190 200
KSSLLVEAGE ATRFTSKDAC KILRNDEIIS LELEIGLINE SEQDLDLELR

LGFA
Length:204
Mass (Da):23,084
Last modified:November 1, 1996 - v1
Checksum:i2CF36E29A821F76E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38946 Genomic DNA Translation: AAC49116.1
AB025608 Genomic DNA Translation: BAA95724.1
CP002686 Genomic DNA Translation: AEE76721.1
DQ056605 mRNA Translation: AAY78753.1
PIRiS60325
RefSeqiNP_188954.1, NM_113214.2
UniGeneiAt.53448

Genome annotation databases

EnsemblPlantsiAT3G23130.1; AT3G23130.1; AT3G23130
GeneIDi821888
GrameneiAT3G23130.1; AT3G23130.1; AT3G23130
KEGGiath:AT3G23130

Similar proteinsi

Entry informationi

Entry nameiSUP_ARATH
AccessioniPrimary (citable) accession number: Q38895
Secondary accession number(s): Q4PSN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health