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Protein

Eukaryotic translation initiation factor 3 subunit I

Gene

TIF3I1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • response to cadmium ion Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-ATH-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-ATH-72689 Formation of a pool of free 40S subunits
R-ATH-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-ATH-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit IUniRule annotation
Short name:
eIF3iUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 2UniRule annotation
TGF-beta receptor-interacting protein 1
Short name:
TRIP-1
eIF-3-betaUniRule annotation
eIF3 p36UniRule annotation
Gene namesi
Name:TIF3I1
Ordered Locus Names:At2g46280
ORF Names:T3F17.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G46280
TAIRilocus:2063009 AT2G46280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510391 – 328Eukaryotic translation initiation factor 3 subunit IAdd BLAST328

Proteomic databases

PaxDbiQ38884
PRIDEiQ38884

PTM databases

iPTMnetiQ38884

Expressioni

Gene expression databases

ExpressionAtlasiQ38884 baseline and differential
GenevisibleiQ38884 AT

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

BioGridi45715 interactors.
IntActiQ38884 2 interactors.
STRINGi3702.AT2G46280.1

Structurei

3D structure databases

ProteinModelPortaliQ38884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 49WD 1Add BLAST42
Repeati50 – 89WD 2Add BLAST40
Repeati146 – 185WD 3Add BLAST40
Repeati191 – 230WD 4Add BLAST40
Repeati288 – 327WD 5Add BLAST40

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0643 Eukaryota
ENOG410XQ3E LUCA
HOGENOMiHOG000231322
InParanoidiQ38884
KOiK03246
OMAiFETRFWH
OrthoDBiEOG09360FYR
PhylomeDBiQ38884

Family and domain databases

Gene3Di2.130.10.101 hit
HAMAPiMF_03008 eIF3i, 1 hit
InterProiView protein in InterPro
IPR027525 eIF3i
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19877 PTHR19877, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q38884-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPILMKGHE RPLTFLRYNR EGDLLFSCAK DHTPTLWFAD NGERLGTYRG
60 70 80 90 100
HNGAVWCCDV SRDSSRLITG SADQTAKLWD VKSGKELFTF KFNAPTRSVD
110 120 130 140 150
FAVGDRLAVI TTDHFVDRTA AIHVKRIAED PEEQDAESVL VLHCPDGKKR
160 170 180 190 200
INRAVWGPLN QTIVSGGEDK VIRIWDAETG KLLKQSDEEV GHKKDITSLC
210 220 230 240 250
KAADDSHFLT GSLDKTAKLW DMRTLTLLKT YTTVVPVNAV SLSPLLNHVV
260 270 280 290 300
LGGGQDASAV TTTDHRAGKF EAKFYDKILQ EEIGGVKGHF GPINALAFNP
310 320
DGKSFSSGGE DGYVRLHHFD SDYFNIKI
Length:328
Mass (Da):36,388
Last modified:September 19, 2002 - v2
Checksum:i4ABFE9866A09CFAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21 – 23EGD → QPH in AAG53616 (PubMed:11042177).Curated3
Sequence conflicti107L → F in AAG53616 (PubMed:11042177).Curated1
Sequence conflicti126 – 128RIA → AYC in AAC49079 (PubMed:7566156).Curated3
Sequence conflicti166G → C in AAC49079 (PubMed:7566156).Curated1
Sequence conflicti255Q → E in AAC49079 (PubMed:7566156).Curated1
Sequence conflicti275Y → C in AAC49079 (PubMed:7566156).Curated1
Sequence conflicti304S → G in AAK43862 (PubMed:14593172).Curated1
Sequence conflicti304S → G in AAL47346 (PubMed:14593172).Curated1
Sequence conflicti311D → G in AAC49079 (PubMed:7566156).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36765 mRNA Translation: AAC49079.1
AF285835 mRNA Translation: AAG53616.1
AC005397 Genomic DNA Translation: AAC62878.1
CP002685 Genomic DNA Translation: AEC10670.1
CP002685 Genomic DNA Translation: AEC10671.1
AF370485 mRNA Translation: AAK43862.1
AY064633 mRNA Translation: AAL47346.1
PIRiH84900
S60256
RefSeqiNP_182151.1, NM_130191.6 [Q38884-1]
NP_850450.1, NM_180119.3 [Q38884-1]
UniGeneiAt.21646

Genome annotation databases

EnsemblPlantsiAT2G46280.1; AT2G46280.1; AT2G46280 [Q38884-1]
AT2G46280.2; AT2G46280.2; AT2G46280 [Q38884-1]
GeneIDi819236
GrameneiAT2G46280.1; AT2G46280.1; AT2G46280 [Q38884-1]
AT2G46280.2; AT2G46280.2; AT2G46280 [Q38884-1]
KEGGiath:AT2G46280

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEIF3I_ARATH
AccessioniPrimary (citable) accession number: Q38884
Secondary accession number(s): O82342, Q94K09, Q9C5Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: April 25, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome