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Protein

Thioredoxin H2

Gene

TRX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei53Deprotonates C-terminal active site CysBy similarity1
Active sitei59NucleophileBy similarity1
Sitei60Contributes to redox potential valueBy similarity1
Sitei61Contributes to redox potential valueBy similarity1
Active sitei62NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciARA:AT5G39950-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H2
Short name:
AtTrxh2
Alternative name(s):
Thioredoxin 2
Short name:
AtTRX2
Gene namesi
Name:TRX2
Ordered Locus Names:At5g39950
ORF Names:MYH19.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G39950
TAIRilocus:2178007 AT5G39950

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200471 – 133Thioredoxin H2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 62Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ38879
PRIDEiQ38879

Expressioni

Gene expression databases

ExpressionAtlasiQ38879 baseline and differential
GenevisibleiQ38879 AT

Interactioni

Protein-protein interaction databases

IntActiQ38879, 6 interactors
STRINGi3702.AT5G39950.1

Structurei

3D structure databases

ProteinModelPortaliQ38879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 133ThioredoxinPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
InParanoidiQ38879
KOiK03671
OMAiFIAMSAK
OrthoDBiEOG09360XJ5
PhylomeDBiQ38879

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q38879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGALSTVFG SGEDATAAGT ESEPSRVLKF SSSARWQLHF NEIKESNKLL
60 70 80 90 100
VVDFSASWCG PCRMIEPAIH AMADKFNDVD FVKLDVDELP DVAKEFNVTA
110 120 130
MPTFVLVKRG KEIERIIGAK KDELEKKVSK LRA
Length:133
Mass (Da):14,676
Last modified:November 2, 2001 - v2
Checksum:iBC034E2BCD4D3CA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7T → I in AAC49353 (PubMed:8642611).Curated1
Sequence conflicti22S → SS in AAC49353 (PubMed:8642611).Curated1
Sequence conflicti127K → Q in AAC49353 (PubMed:8642611).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35475 mRNA Translation: CAA84612.1
U35826 Genomic DNA Translation: AAC49353.1
AB010077 Genomic DNA Translation: BAB10219.1
CP002688 Genomic DNA Translation: AED94495.1
AY048235 mRNA Translation: AAK82498.1
AY113052 mRNA Translation: AAM47360.1
PIRiS58123
RefSeqiNP_198811.1, NM_123358.4
UniGeneiAt.10806
At.27173
At.30316
At.70939

Genome annotation databases

EnsemblPlantsiAT5G39950.1; AT5G39950.1; AT5G39950
GeneIDi833992
GrameneiAT5G39950.1; AT5G39950.1; AT5G39950
KEGGiath:AT5G39950

Similar proteinsi

Entry informationi

Entry nameiTRXH2_ARATH
AccessioniPrimary (citable) accession number: Q38879
Secondary accession number(s): Q39240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: April 25, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health