Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin H2

Gene

TRX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei53 – 531Deprotonates C-terminal active site CysBy similarity
Active sitei59 – 591NucleophileBy similarity
Sitei60 – 601Contributes to redox potential valueBy similarity
Sitei61 – 611Contributes to redox potential valueBy similarity
Active sitei62 – 621NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciARA:AT5G39950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H2
Short name:
AtTrxh2
Alternative name(s):
Thioredoxin 2
Short name:
AtTRX2
Gene namesi
Name:TRX2
Ordered Locus Names:At5g39950
ORF Names:MYH19.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G39950.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Thioredoxin H2PRO_0000120047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 62Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ38879.
PRIDEiQ38879.

Expressioni

Gene expression databases

GenevisibleiQ38879. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G39950.1.

Structurei

3D structure databases

ProteinModelPortaliQ38879.
SMRiQ38879. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 133128ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
InParanoidiQ38879.
KOiK03671.
OMAiLHFNEIK.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ38879.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGALSTVFG SGEDATAAGT ESEPSRVLKF SSSARWQLHF NEIKESNKLL
60 70 80 90 100
VVDFSASWCG PCRMIEPAIH AMADKFNDVD FVKLDVDELP DVAKEFNVTA
110 120 130
MPTFVLVKRG KEIERIIGAK KDELEKKVSK LRA
Length:133
Mass (Da):14,676
Last modified:November 2, 2001 - v2
Checksum:iBC034E2BCD4D3CA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71T → I in AAC49353 (PubMed:8642611).Curated
Sequence conflicti22 – 221S → SS in AAC49353 (PubMed:8642611).Curated
Sequence conflicti127 – 1271K → Q in AAC49353 (PubMed:8642611).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35475 mRNA. Translation: CAA84612.1.
U35826 Genomic DNA. Translation: AAC49353.1.
AB010077 Genomic DNA. Translation: BAB10219.1.
CP002688 Genomic DNA. Translation: AED94495.1.
AY048235 mRNA. Translation: AAK82498.1.
AY113052 mRNA. Translation: AAM47360.1.
PIRiS58123.
RefSeqiNP_198811.1. NM_123358.3.
UniGeneiAt.10806.
At.27173.
At.30316.
At.70939.

Genome annotation databases

EnsemblPlantsiAT5G39950.1; AT5G39950.1; AT5G39950.
GeneIDi833992.
GrameneiAT5G39950.1; AT5G39950.1; AT5G39950.
KEGGiath:AT5G39950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35475 mRNA. Translation: CAA84612.1.
U35826 Genomic DNA. Translation: AAC49353.1.
AB010077 Genomic DNA. Translation: BAB10219.1.
CP002688 Genomic DNA. Translation: AED94495.1.
AY048235 mRNA. Translation: AAK82498.1.
AY113052 mRNA. Translation: AAM47360.1.
PIRiS58123.
RefSeqiNP_198811.1. NM_123358.3.
UniGeneiAt.10806.
At.27173.
At.30316.
At.70939.

3D structure databases

ProteinModelPortaliQ38879.
SMRiQ38879. Positions 47-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G39950.1.

Proteomic databases

PaxDbiQ38879.
PRIDEiQ38879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G39950.1; AT5G39950.1; AT5G39950.
GeneIDi833992.
GrameneiAT5G39950.1; AT5G39950.1; AT5G39950.
KEGGiath:AT5G39950.

Organism-specific databases

TAIRiAT5G39950.

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
InParanoidiQ38879.
KOiK03671.
OMAiLHFNEIK.
OrthoDBiEOG09360XJ5.
PhylomeDBiQ38879.

Enzyme and pathway databases

BioCyciARA:AT5G39950-MONOMER.

Miscellaneous databases

PROiQ38879.

Gene expression databases

GenevisibleiQ38879. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXH2_ARATH
AccessioniPrimary (citable) accession number: Q38879
Secondary accession number(s): Q39240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.