Agamous-like MADS-box protein AGL8 - Arabidopsis thaliana (Mouse-ear cress)

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Reviewed, UniProtKB/Swiss-Prot Q38876 (AGL8_ARATH)

Last modified June 16, 2009. Version 79. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Agamous-like MADS-box protein AGL8
Alternative name(s):
    Floral homeotic protein AGL8
    Transcription factor FRUITFULL

Gene names

Name:	AGL8
Synonyms:	FUL
Ordered Locus Names:	At5g60910
ORF Names:	MSL3.3

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1 and CAULIFLOWER. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1 and CAULIFLOWER in the up-regulation of LEAFY. Is also required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique. Probably not required for fruit elongation but instead is required to prevent ectopic activity of IND. Ref.4 Ref.5 Ref.6
Subunit structure	Homodimer capable of binding to CArG-box sequences By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Vascular tissue of cauline leaves, floral shoot apex and valves of carpels and fruits. Ref.4
Induction	Dramatically up-regulated upon the transition from vegetative to reproductive development.
Sequence similarities	Contains 1 K-box domain. Contains 1 MADS-box domain.

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Ontologies

Keywords
Biological process	Differentiation Flowering Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW flower development Inferred from electronic annotation. Source: UniProtKB-KW fruit development Ref.4 Inferred from mutant phenotype. Source: TAIR positive regulation of flower development Traceable author statement. Source: TAIR regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q2V412	1	EBI-621912,EBI-1238781
AG	P17839	1	EBI-621912,EBI-592365
AGL14	Q38838	1	EBI-621912,EBI-622067
AGL21	Q9SZJ6	1	EBI-621912,EBI-621986
AGL24	O82794	1	EBI-621912,EBI-592083
AGL3	P29383	1	EBI-621912,EBI-622036
AGL6	P29386	1	EBI-621912,EBI-621968
CALM	P62157	1	EBI-621912,EBI-397403	From a different organism.
CAM1	P25854	1	EBI-621912,EBI-1235664
CML8	O23320	1	EBI-621912,EBI-1237764
SEP1	Q5XXN7	1	EBI-621912,EBI-621940
SEP3	O22456	1	EBI-621912,EBI-592020
SOC1	O64645	1	EBI-621912,EBI-592041

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Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q38876-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 242

242

Agamous-like MADS-box protein AGL8

PRO_0000199461

Regions

Domain

3 – 57

MADS-box

Domain

88 – 178

K-box

Coiled coil

89 – 178

Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 516499731EADB2D2
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FASTA

242

27,536

        10         20         30         40         50         60 
MGRGRVQLKR IENKINRQVT FSKRRSGLLK KAHEISVLCD AEVALIVFSS KGKLFEYSTD 

        70         80         90        100        110        120 
SCMERILERY DRYLYSDKQL VGRDVSQSEN WVLEHAKLKA RVEVLEKNKR NFMGEDLDSL 

       130        140        150        160        170        180 
SLKELQSLEH QLDAAIKSIR SRKNQAMFES ISALQKKDKA LQDHNNSLLK KIKEREKKTG 

       190        200        210        220        230        240 
QQEGQLVQCS NSSSVLLPQY CVTSSRDGFV ERVGGENGGA SSLTEPNSLL PAWMLRPTTT 


NE

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Arabidopsis AGL8 MADS box gene is expressed in inflorescence meristems and is negatively regulated by APETALA1." Mandel M.A., Yanofsky M.F. Plant Cell 7:1763-1771(1995) [PubMed: 8535133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones." Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S. DNA Res. 4:401-414(1997) [PubMed: 9501997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development." Gu Q., Ferrandiz C., Yanofsky M.F., Martienssen R. Development 125:1509-1517(1998) [PubMed: 9502732] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. Strain: cv. Landsberg erecta.
[5]	"Redundant regulation of meristem identity and plant architecture by FRUITFULL, APETALA1 and CAULIFLOWER." Ferrandiz C., Gu Q., Martienssen R., Yanofsky M.F. Development 127:725-734(2000) [PubMed: 10648231] [Abstract] Cited for: FUNCTION.
[6]	"Control of fruit patterning in Arabidopsis by INDEHISCENT." Liljegren S.J., Roeder A.H.K., Kempin S.A., Gremski K., Ostergaard L., Guimil S., Reyes D.K., Yanofsky M.F. Cell 116:843-853(2004) [PubMed: 15035986] [Abstract] Cited for: FUNCTION.

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Cross-references

Sequence databases
	U33473 mRNA. Translation: AAA97403.1. AB008269 Genomic DNA. Translation: BAB10640.1. AF386929 mRNA. Translation: AAK62374.1. AY072463 mRNA. Translation: AAL66878.1.
IPI	IPI00522952.
PIR	S71208.
RefSeq	NP_568929.1.
UniGene	At.5426
3D structure databases
HSSP	HSSP built from PDB template 1EGW based on UniProtKB Q02078.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q38876. 13 interactions.
Genome annotation databases
GeneID	836212.
GenomeReviews	Gene locus AT5G60910 in contig BA000015_GR.
NMPDR	fig\|3702.1.peg.28106.
Organism-specific databases
GeneFarm	3484. 348.
TAIR	At5g60910.
Phylogenomic databases
OMA	Q38876. GILERYQ.
Gene expression databases
ArrayExpress	Q38876.
GermOnline	AT5G60910. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002487. TF_Kbox. IPR002100. TF_MADSbox. [Graphical view]
Pfam	PF01486. K-box. 1 hit. PF00319. SRF-TF. 1 hit. [Graphical view]
PRINTS	PR00404. MADSDOMAIN.
SMART	SM00432. MADS. 1 hit. [Graphical view]
PROSITE	PS51297. K_BOX. 1 hit. PS00350. MADS_BOX_1. 1 hit. PS50066. MADS_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

AGL8_ARATH

Accession

Primary (citable) accession number: Q38876

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents