Reviewed,
UniProtKB/Swiss-Prot Q38876 (AGL8_ARATH)
Last modified
June 16, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Agamous-like MADS-box protein AGL8 Alternative name(s): Floral homeotic protein AGL8 Transcription factor FRUITFULL | ||||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1 and CAULIFLOWER. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1 and CAULIFLOWER in the up-regulation of LEAFY. Is also required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique. Probably not required for fruit elongation but instead is required to prevent ectopic activity of IND. Ref.4 Ref.5 Ref.6 |
| Subunit structure | Homodimer capable of binding to CArG-box sequences By similarity. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Vascular tissue of cauline leaves, floral shoot apex and valves of carpels and fruits. Ref.4 |
| Induction | Dramatically up-regulated upon the transition from vegetative to reproductive development. |
| Sequence similarities | Contains 1 K-box domain. Contains 1 MADS-box domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Q2V412 | 1 | EBI-621912,EBI-1238781 | ||
| AG | P17839 | 1 | EBI-621912,EBI-592365 | |
| AGL14 | Q38838 | 1 | EBI-621912,EBI-622067 | |
| AGL21 | Q9SZJ6 | 1 | EBI-621912,EBI-621986 | |
| AGL24 | O82794 | 1 | EBI-621912,EBI-592083 | |
| AGL3 | P29383 | 1 | EBI-621912,EBI-622036 | |
| AGL6 | P29386 | 1 | EBI-621912,EBI-621968 | |
| CALM | P62157 | 1 | EBI-621912,EBI-397403 | From a different organism. |
| CAM1 | P25854 | 1 | EBI-621912,EBI-1235664 | |
| CML8 | O23320 | 1 | EBI-621912,EBI-1237764 | |
| SEP1 | Q5XXN7 | 1 | EBI-621912,EBI-621940 | |
| SEP3 | O22456 | 1 | EBI-621912,EBI-592020 | |
| SOC1 | O64645 | 1 | EBI-621912,EBI-592041 |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q38876-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Arabidopsis AGL8 MADS box gene is expressed in inflorescence meristems and is negatively regulated by APETALA1." Mandel M.A., Yanofsky M.F. Plant Cell 7:1763-1771(1995) [PubMed: 8535133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. |
| [2] | "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones." Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S. DNA Res. 4:401-414(1997) [PubMed: 9501997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [4] | "The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development." Gu Q., Ferrandiz C., Yanofsky M.F., Martienssen R. Development 125:1509-1517(1998) [PubMed: 9502732] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. Strain: cv. Landsberg erecta. |
| [5] | "Redundant regulation of meristem identity and plant architecture by FRUITFULL, APETALA1 and CAULIFLOWER." Ferrandiz C., Gu Q., Martienssen R., Yanofsky M.F. Development 127:725-734(2000) [PubMed: 10648231] [Abstract] Cited for: FUNCTION. |
| [6] | "Control of fruit patterning in Arabidopsis by INDEHISCENT." Liljegren S.J., Roeder A.H.K., Kempin S.A., Gremski K., Ostergaard L., Guimil S., Reyes D.K., Yanofsky M.F. Cell 116:843-853(2004) [PubMed: 15035986] [Abstract] Cited for: FUNCTION. |
Cross-references
Sequence databases | |
|---|---|
| U33473 mRNA. Translation: AAA97403.1. AB008269 Genomic DNA. Translation: BAB10640.1. AF386929 mRNA. Translation: AAK62374.1. AY072463 mRNA. Translation: AAL66878.1. | |
| IPI | IPI00522952. |
| PIR | S71208. |
| RefSeq | NP_568929.1. |
| UniGene | At.5426 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EGW based on UniProtKB Q02078. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q38876. 13 interactions. |
Genome annotation databases | |
| GeneID | 836212. |
| GenomeReviews | Gene locus AT5G60910 in contig BA000015_GR. |
| NMPDR | fig|3702.1.peg.28106. |
Organism-specific databases | |
| GeneFarm | 3484. 348. |
| TAIR | At5g60910. |
Phylogenomic databases | |
| OMA | Q38876. GILERYQ. |
Gene expression databases | |
| ArrayExpress | Q38876. |
| GermOnline | AT5G60910. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR002487. TF_Kbox. IPR002100. TF_MADSbox. [Graphical view] |
| Pfam | PF01486. K-box. 1 hit. PF00319. SRF-TF. 1 hit. [Graphical view] |
| PRINTS | PR00404. MADSDOMAIN. |
| SMART | SM00432. MADS. 1 hit. [Graphical view] |
| PROSITE | PS51297. K_BOX. 1 hit. PS00350. MADS_BOX_1. 1 hit. PS50066. MADS_BOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AGL8_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q38876 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


