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Protein

Peptidyl-prolyl cis-trans isomerase CYP19-3

Gene

CYP19-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity).By similarity

GO - Molecular functioni

  • cyclosporin A binding Source: TAIR
  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • response to cadmium ion Source: TAIR
  • signal transduction Source: TAIR

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP19-3 (EC:5.2.1.8)
Short name:
PPIase CYP19-3
Alternative name(s):
Cyclophilin of 19 kDa 3
Cyclophilin-4
Rotamase cyclophilin-2
Gene namesi
Name:CYP19-3
Synonyms:CYP4, ROC2
Ordered Locus Names:At3g56070
ORF Names:F18O21.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G56070.
TAIRilocus:2078451. AT3G56070.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641371 – 176Peptidyl-prolyl cis-trans isomerase CYP19-3Add BLAST176

Proteomic databases

PaxDbiQ38867.
PRIDEiQ38867.

PTM databases

SwissPalmiQ38867.

Expressioni

Tissue specificityi

Ubiquitous, with highest levels in flowers and lowest levels in roots.2 Publications

Inductioni

By wounding, and slightly by light.1 Publication

Gene expression databases

ExpressionAtlasiQ38867. baseline and differential.
GenevisibleiQ38867. AT.

Interactioni

Protein-protein interaction databases

BioGridi10089. 1 interactor.
IntActiQ38867. 4 interactors.
STRINGi3702.AT3G56070.1.

Structurei

3D structure databases

ProteinModelPortaliQ38867.
SMRiQ38867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 170PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ38867.
KOiK01802.
OMAiFFINFKD.
OrthoDBiEOG09360PV0.
PhylomeDBiQ38867.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom_sf.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPKVFFDI LIGKMKAGRV VMELFADVTP RTANNFRALC TGENGIGKAG
60 70 80 90 100
KALHYKGSAF HRIIPGFMCQ GGDFTRGNGT GGESIYGSKF EDENFKLKHT
110 120 130 140 150
GPGILSMANS GPNTNGSQFF ICTEKTSWLD GKHVVFGKVV DGYNVVKAME
160 170
DVGSDMGNPS ERVVIEDCGE LKNPSS
Length:176
Mass (Da):18,921
Last modified:December 20, 2005 - v2
Checksum:i24C2031B6CB4DD90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155D → Y in AAA74096 (Ref. 2) Curated1
Sequence conflicti172K → N in AAB96833 (PubMed:9426607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40400 Genomic DNA. Translation: AAB96833.1.
U31370 Genomic DNA. Translation: AAA74096.1.
AL163763 Genomic DNA. Translation: CAB87406.1.
CP002686 Genomic DNA. Translation: AEE79473.1.
CP002686 Genomic DNA. Translation: AEE79474.1.
AY072128 mRNA. Translation: AAL59950.1.
AY096697 mRNA. Translation: AAM20331.1.
PIRiT47724.
T50767.
RefSeqiNP_001319764.1. NM_001339763.1.
NP_191166.1. NM_115465.5.
UniGeneiAt.34965.

Genome annotation databases

EnsemblPlantsiAT3G56070.1; AT3G56070.1; AT3G56070.
AT3G56070.2; AT3G56070.2; AT3G56070.
GeneIDi824773.
GrameneiAT3G56070.1; AT3G56070.1; AT3G56070.
AT3G56070.2; AT3G56070.2; AT3G56070.
KEGGiath:AT3G56070.

Similar proteinsi

Entry informationi

Entry nameiCP19C_ARATH
AccessioniPrimary (citable) accession number: Q38867
Secondary accession number(s): Q38901, Q9LYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 22, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families