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Protein

Ethylene response sensor 1

Gene

ERS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65CopperBy similarity1
Metal bindingi69CopperBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ethylene binding Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • phosphorelay sensor kinase activity Source: InterPro
  • protein histidine kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processEthylene signaling pathway, Two-component regulatory system
LigandATP-binding, Copper, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene response sensor 1 (EC:2.7.11.-, EC:2.7.13.3)
Short name:
AtERS1
Alternative name(s):
Protein ERS1
Gene namesi
Name:ERS1
Synonyms:ERS
Ordered Locus Names:At2g40940
ORF Names:T20B5.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G40940
TAIRilocus:2058500 AT2G40940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype in ethylene response; due to the redundancy with ETR1. Ers1 and etr1 double mutants display a constitutive ethylene-response phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003781421 – 613Ethylene response sensor 1Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4InterchainBy similarity
Disulfide bondi6InterchainBy similarity
Modified residuei353Phosphohistidine; by autocatalysisPROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Autophosphorylated on both His and Ser residues in the presence of manganese. Loss of His autophosphorylation in the presence of both manganese and magnesium.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ38846

Expressioni

Tissue specificityi

Expressed in etiolated seedlings, leaves, stems, roots, flowers, embryos, anthers, carpels and ovules.1 Publication

Inductioni

By ethylene.2 Publications

Gene expression databases

ExpressionAtlasiQ38846 baseline and differential
GenevisibleiQ38846 AT

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heteromer with ETR1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4030, 6 interactors
IntActiQ38846, 5 interactors
STRINGi3702.AT2G40940.1

Structurei

Secondary structure

1613
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi309 – 370Combined sources62
Helixi376 – 403Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MT8X-ray1.90A/B308-407[»]
4MTXX-ray2.15A/B/C/D308-407[»]
ProteinModelPortaliQ38846
SMRiQ38846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 307GAFAdd BLAST150
Domaini350 – 589Histidine kinasePROSITE-ProRule annotationAdd BLAST240

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi592 – 597Poly-Ser6

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRCC Eukaryota
ENOG410ZCWX LUCA
HOGENOMiHOG000240343
InParanoidiQ38846
KOiK14509
OMAiIWQQTVD
OrthoDBiEOG093605FG
PhylomeDBiQ38846

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.450.40, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF01590 GAF, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q38846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESCDCFETH VNQDDLLVKY QYISDALIAL AYFSIPLELI YFVQKSAFFP
60 70 80 90 100
YKWVLMQFGA FIILCGATHF INLWMFFMHS KAVAIVMTIA KVSCAVVSCA
110 120 130 140 150
TALMLVHIIP DLLSVKNREL FLKKKADELD REMGLILTQE ETGRHVRMLT
160 170 180 190 200
HGIRRTLDRH TILRTTLVEL GKTLCLEECA LWMPSQSGLY LQLSHTLSHK
210 220 230 240 250
IQVGSSVPIN LPIINELFNS AQAMHIPHSC PLAKIGPPVG RYSPPEVVSV
260 270 280 290 300
RVPLLHLSNF QGSDWSDLSG KGYAIMVLIL PTDGARKWRD HELELVENVA
310 320 330 340 350
DQVAVALSHA AILEESMHAR DQLMEQNFAL DKARQEAEMA VHARNDFLAV
360 370 380 390 400
MNHEMRTPMH AIISLSSLLL ETELSPEQRV MIETILKSSN LVATLISDVL
410 420 430 440 450
DLSRLEDGSL LLENEPFSLQ AIFEEVISLI KPIASVKKLS TNLILSADLP
460 470 480 490 500
TYAIGDEKRL MQTILNIMGN AVKFTKEGYI SIIASIMKPE SLQELPSPEF
510 520 530 540 550
FPVLSDSHFY LCVQVKDTGC GIHTQDIPLL FTKFVQPRTG TQRNHSGGGL
560 570 580 590 600
GLALCKRFVG LMGGYMWIES EGLEKGCTAS FIIRLGICNG PSSSSGSMAL
610
HLAAKSQTRP WNW
Length:613
Mass (Da):68,333
Last modified:November 1, 1996 - v1
Checksum:iE4F5DB384E6727B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21952 Genomic DNA Translation: AAC49090.1
AC002409 Genomic DNA Translation: AAB86454.1
CP002685 Genomic DNA Translation: AEC09904.1
AY054532 mRNA Translation: AAK96723.1
BT000159 mRNA Translation: AAN15478.1
PIRiT00758
RefSeqiNP_181626.1, NM_129658.4
UniGeneiAt.21783
At.66415

Genome annotation databases

EnsemblPlantsiAT2G40940.1; AT2G40940.1; AT2G40940
GeneIDi818693
GrameneiAT2G40940.1; AT2G40940.1; AT2G40940
KEGGiath:AT2G40940

Similar proteinsi

Entry informationi

Entry nameiERS1_ARATH
AccessioniPrimary (citable) accession number: Q38846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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