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Protein

Agamous-like MADS-box protein AGL12

Gene

AGL12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription activator that regulates root development by controlling cell proliferation in root meristem. May mediate responses to auxin in the root. May act as promoter of the flowering transition through up-regulation of SOC, FT and LFY.1 Publication

GO - Molecular functioni

GO - Biological processi

  • flower development Source: UniProtKB-KW
  • MAPK cascade Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  • regulation of growth Source: UniProtKB-KW
  • root development Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • vegetative to reproductive phase transition of meristem Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Flowering, Growth regulation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Agamous-like MADS-box protein AGL12Curated
Alternative name(s):
Protein XAANTAL 11 Publication
Gene namesi
Name:AGL121 Publication
Synonyms:XAL11 Publication
Ordered Locus Names:At1g71692Imported
ORF Names:F14O23.5, F26A9.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G71692.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Retarded root growth, and altered root meristem size and stem-cell patterning. Late flowering phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994711 – 211Agamous-like MADS-box protein AGL12Add BLAST211

Proteomic databases

PaxDbiQ38841.

Expressioni

Tissue specificityi

Preferentially expressed in roots (PubMed:7549482). In root meristem, expressed in external cells of columella, lateral root cap and atrichoblasts. In mature root, expressed in the central cylinder (PubMed:11855641). Expressed in leaf vasculature, young floral meristems and nectaries (PubMed:18203871).3 Publications

Developmental stagei

During embryo development, expressed in a punctate pattern from the globular stage to the torpedo stage.1 Publication

Inductioni

By auxin in root phloem.1 Publication

Gene expression databases

ExpressionAtlasiQ38841. baseline and differential.
GenevisibleiQ38841. AT.

Interactioni

Protein-protein interaction databases

BioGridi28717. 5 interactors.
DIPiDIP-33766N.
IntActiQ38841. 5 interactors.
STRINGi3702.AT1G71692.1.

Structurei

3D structure databases

ProteinModelPortaliQ38841.
SMRiQ38841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55
Domaini95 – 185K-boxPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 K-box domain.PROSITE-ProRule annotation
Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ38841.
OMAiLEYWISQ.
OrthoDBiEOG09360MH2.
PhylomeDBiQ38841.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKIQLKR IENPVHRQVT FCKRRTGLLK KAKELSVLCD AEIGVVIFSP
60 70 80 90 100
QGKLFELATK GTMEGMIDKY MKCTGGGRGS SSATFTAQEQ LQPPNLDPKD
110 120 130 140 150
EINVLKQEIE MLQKGISYMF GGGDGAMNLE ELLLLEKHLE YWISQIRSAK
160 170 180 190 200
MDVMLQEIQS LRNKEGVLKN TNKYLLEKIE ENNNSILDAN FAVMETNYSY
210
PLTMPSEIFQ F
Length:211
Mass (Da):23,919
Last modified:January 11, 2001 - v2
Checksum:iB606BD2622043D5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177E → D in AAC49085 (PubMed:7549482).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20193 mRNA. Translation: AAC49085.1.
AC012654 Genomic DNA. Translation: AAF43220.1.
AC016163 Genomic DNA. Translation: AAG51837.1.
CP002684 Genomic DNA. Translation: AEE35216.1.
BT006157 mRNA. Translation: AAP04142.1.
BT008332 mRNA. Translation: AAP37691.1.
BT008524 mRNA. Translation: AAP40351.1.
AK228190 mRNA. Translation: BAF00144.1.
PIRiH96738.
RefSeqiNP_565022.1. NM_105825.3.
UniGeneiAt.19719.

Genome annotation databases

EnsemblPlantsiAT1G71692.1; AT1G71692.1; AT1G71692.
GeneIDi843497.
GrameneiAT1G71692.1; AT1G71692.1; AT1G71692.
KEGGiath:AT1G71692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20193 mRNA. Translation: AAC49085.1.
AC012654 Genomic DNA. Translation: AAF43220.1.
AC016163 Genomic DNA. Translation: AAG51837.1.
CP002684 Genomic DNA. Translation: AEE35216.1.
BT006157 mRNA. Translation: AAP04142.1.
BT008332 mRNA. Translation: AAP37691.1.
BT008524 mRNA. Translation: AAP40351.1.
AK228190 mRNA. Translation: BAF00144.1.
PIRiH96738.
RefSeqiNP_565022.1. NM_105825.3.
UniGeneiAt.19719.

3D structure databases

ProteinModelPortaliQ38841.
SMRiQ38841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28717. 5 interactors.
DIPiDIP-33766N.
IntActiQ38841. 5 interactors.
STRINGi3702.AT1G71692.1.

Proteomic databases

PaxDbiQ38841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G71692.1; AT1G71692.1; AT1G71692.
GeneIDi843497.
GrameneiAT1G71692.1; AT1G71692.1; AT1G71692.
KEGGiath:AT1G71692.

Organism-specific databases

TAIRiAT1G71692.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ38841.
OMAiLEYWISQ.
OrthoDBiEOG09360MH2.
PhylomeDBiQ38841.

Miscellaneous databases

PROiQ38841.

Gene expression databases

ExpressionAtlasiQ38841. baseline and differential.
GenevisibleiQ38841. AT.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGL12_ARATH
AccessioniPrimary (citable) accession number: Q38841
Secondary accession number(s): Q0WRV5, Q9SF79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

XAANTAL is the Mayan word for "go slower" in recognition of the retarded root growth phenotypes of xaantal mutants.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.