Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Agamous-like MADS-box protein AGL14

Gene

AGL14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates root development by controlling meristem size and patterning of the root apical meristem. Regulates auxin transport and gradients in the root meristematic cells via direct regulation of the auxin efflux carrier PIN1 and PIN4 gene expression. Binds specifically to the CArG-box DNA sequences in the promoter regions of PIN1 and PIN4 genes (PubMed:24121311). Involved in the regulation of shoot apical meristem (SAM) cell identities and transitions. Promotes flowering transition and participates in flower meristem maintenance and determinacy. Positively regulates TFL1 and WUS expression. Binds directly to the TFL1 regulatory sequences (PubMed:25636918).1 Publication

GO - Molecular functioni

GO - Biological processi

  • flower development Source: UniProtKB-KW
  • maintenance of floral meristem identity Source: UniProtKB
  • MAPK cascade Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  • regulation of auxin polar transport Source: UniProtKB
  • regulation of root meristem growth Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • vegetative to reproductive phase transition of meristem Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Flowering, Growth regulation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Agamous-like MADS-box protein AGL14Curated
Alternative name(s):
Protein XAANTAL 21 Publication
Gene namesi
Name:AGL141 Publication
Synonyms:XAL21 Publication
Ordered Locus Names:At4g11880Imported
ORF Names:T26M18.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G11880.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Retarded root growth, and altered root meristem size and stem-cell patterning (PubMed:24121311). Late flowering phenotype (PubMed:25636918).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994731 – 221Agamous-like MADS-box protein AGL14Add BLAST221

Proteomic databases

PaxDbiQ38838.

Expressioni

Tissue specificityi

Preferentially expressed in roots (PubMed:7549482). Expressed in lateral root cap, root epidermis, root endodermis, columella of the root meristematic region, the vascular cylinder in differentiated zones of the primary root and in emerged lateral root primordia (PubMed:24121311). Expressed in pollen (PubMed:12949148).3 Publications

Developmental stagei

During floral transition, expressed very early at the flanks of the inflorescence meristem in the anlagens upon the transition to flowering Subsequently, expression levels increase in the first and second stages of the floral meristem and at stage 3, expression is restricted to the L1 and L2 layers. Later on, expressed in the gynoecium and stamen primordia at stage 6.1 Publication

Inductioni

By auxin.1 Publication

Gene expression databases

ExpressionAtlasiQ38838. baseline and differential.
GenevisibleiQ38838. AT.

Interactioni

Subunit structurei

Interacts with AGL16.1 Publication

Protein-protein interaction databases

BioGridi12093. 4 interactors.
DIPiDIP-33798N.
IntActiQ38838. 13 interactors.
STRINGi3702.AT4G11880.1.

Structurei

3D structure databases

ProteinModelPortaliQ38838.
SMRiQ38838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55
Domaini87 – 177K-boxPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 K-box domain.PROSITE-ProRule annotation
Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ38838.
OMAiEISTRKM.
OrthoDBiEOG0936106C.
PhylomeDBiQ38838.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRGKTEMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVALIIFSP
60 70 80 90 100
RGKLYEFSSS SSIPKTVERY QKRIQDLGSN HKRNDNSQQS KDETYGLARK
110 120 130 140 150
IEHLEISTRK MMGEGLDASS IEELQQLENQ LDRSLMKIRA KKYQLLREET
160 170 180 190 200
EKLKEKERNL IAENKMLMEK CEMQGRGIIG RISSSSSTSE LDIDDNEMEV
210 220
VTDLFIGPPE TRHFKKFPPS N
Length:221
Mass (Da):25,492
Last modified:January 11, 2001 - v2
Checksum:iE876DAEA049B125E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103H → D in AAC49082 (PubMed:7549482).Curated1
Sequence conflicti187 – 188ST → TS in AAC49082 (PubMed:7549482).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078606 Genomic DNA. Translation: CAB44326.1.
AL161532 Genomic DNA. Translation: CAB78231.1.
CP002687 Genomic DNA. Translation: AEE83062.1.
AK230464 mRNA. Translation: BAF02258.1.
U20184 mRNA. Translation: AAC49082.1.
PIRiT09347.
RefSeqiNP_192925.1. NM_117258.5.
UniGeneiAt.42992.

Genome annotation databases

EnsemblPlantsiAT4G11880.1; AT4G11880.1; AT4G11880.
GeneIDi826795.
GrameneiAT4G11880.1; AT4G11880.1; AT4G11880.
KEGGiath:AT4G11880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078606 Genomic DNA. Translation: CAB44326.1.
AL161532 Genomic DNA. Translation: CAB78231.1.
CP002687 Genomic DNA. Translation: AEE83062.1.
AK230464 mRNA. Translation: BAF02258.1.
U20184 mRNA. Translation: AAC49082.1.
PIRiT09347.
RefSeqiNP_192925.1. NM_117258.5.
UniGeneiAt.42992.

3D structure databases

ProteinModelPortaliQ38838.
SMRiQ38838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12093. 4 interactors.
DIPiDIP-33798N.
IntActiQ38838. 13 interactors.
STRINGi3702.AT4G11880.1.

Proteomic databases

PaxDbiQ38838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G11880.1; AT4G11880.1; AT4G11880.
GeneIDi826795.
GrameneiAT4G11880.1; AT4G11880.1; AT4G11880.
KEGGiath:AT4G11880.

Organism-specific databases

TAIRiAT4G11880.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ38838.
OMAiEISTRKM.
OrthoDBiEOG0936106C.
PhylomeDBiQ38838.

Miscellaneous databases

PROiQ38838.

Gene expression databases

ExpressionAtlasiQ38838. baseline and differential.
GenevisibleiQ38838. AT.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGL14_ARATH
AccessioniPrimary (citable) accession number: Q38838
Secondary accession number(s): Q0WKU9, Q9T056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

XAANTAL is the Mayan word for "go slower" in recognition of the retarded root growth phenotypes of xaantal mutants.1 Publication
Plants over-expressing AGL14/XAL2 show early flowering phenotype and flowers have vegetative traits.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.