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Protein

Auxin-responsive protein IAA7

Gene

IAA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.1 Publication

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • auxin-activated signaling pathway Source: UniProtKB-KW
  • gravitropism Source: TAIR
  • response to auxin Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to water deprivation Source: TAIR
  • response to wounding Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processAuxin signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin-responsive protein IAA7
Alternative name(s):
Auxin resistant 2
Indoleacetic acid-induced protein 7
Gene namesi
Name:IAA7
Synonyms:AXR2
Ordered Locus Names:At3g23050
ORF Names:MXC7.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G23050.
TAIRilocus:2094598. AT3G23050.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87P → S in axr2-1; gain of function. Affects auxin-related developmental processes. Affects photomorphogenesis. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128381 – 243Auxin-responsive protein IAA7Add BLAST243

Proteomic databases

PaxDbiQ38825.

Expressioni

Tissue specificityi

Highly expressed in stems and flowers.1 Publication

Inductioni

By auxin.1 Publication

Gene expression databases

ExpressionAtlasiQ38825. baseline and differential.
GenevisibleiQ38825. AT.

Interactioni

Subunit structurei

Homodimers and heterodimers.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi7211. 40 interactors.
DIPiDIP-33345N.
IntActiQ38825. 37 interactors.
STRINGi3702.AT3G23050.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P1NX-ray2.50C/F82-94[»]
2P1OX-ray1.90C82-94[»]
2P1QX-ray1.91C82-94[»]
ProteinModelPortaliQ38825.
SMRiQ38825.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ38825.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 224PB1PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 17EAR-like (transcriptional repression)5

Domaini

The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.

Sequence similaritiesi

Belongs to the Aux/IAA family.Curated

Phylogenomic databases

eggNOGiENOG410IK8Z. Eukaryota.
ENOG410YEC3. LUCA.
HOGENOMiHOG000238261.
InParanoidiQ38825.
KOiK14484.
OMAiRIMKGAE.
OrthoDBiEOG09360QD8.
PhylomeDBiQ38825.

Family and domain databases

InterProiView protein in InterPro
IPR033389. AUX/IAA_dom.
IPR003311. AUX_IAA.
IPR000270. PB1_dom.
PANTHERiPTHR31734. PTHR31734. 1 hit.
PfamiView protein in Pfam
PF02309. AUX_IAA. 1 hit.
PROSITEiView protein in PROSITE
PS51745. PB1. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q38825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIGQLMNLKA TELCLGLPGG AEAVESPAKS AVGSKRGFSE TVDLMLNLQS
60 70 80 90 100
NKEGSVDLKN VSAVPKEKTT LKDPSKPPAK AQVVGWPPVR NYRKNMMTQQ
110 120 130 140 150
KTSSGAEEAS SEKAGNFGGG AAGAGLVKVS MDGAPYLRKV DLKMYKSYQD
160 170 180 190 200
LSDALAKMFS SFTMGNYGAQ GMIDFMNESK LMNLLNSSEY VPSYEDKDGD
210 220 230 240
WMLVGDVPWE MFVESCKRLR IMKGSEAVGL APRAMEKYCK NRS
Length:243
Mass (Da):26,381
Last modified:November 1, 1996 - v1
Checksum:i830E9B9EA2C2B5D0
GO

Sequence cautioni

The sequence AAM65301 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228V → I in AAM65301 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18409 mRNA. Translation: AAC49048.1.
AB026655 Genomic DNA. Translation: BAB02096.1.
CP002686 Genomic DNA. Translation: AEE76710.1.
AF332395 mRNA. Translation: AAG48759.1.
AY054651 mRNA. Translation: AAK96842.1.
AY072461 mRNA. Translation: AAL66876.1.
AY087765 mRNA. Translation: AAM65301.1. Different initiation.
PIRiS58494.
RefSeqiNP_188945.1. NM_113205.3. [Q38825-1]
UniGeneiAt.22260.
At.67783.

Genome annotation databases

EnsemblPlantsiAT3G23050.1; AT3G23050.1; AT3G23050. [Q38825-1]
GeneIDi821879.
GrameneiAT3G23050.1; AT3G23050.1; AT3G23050. [Q38825-1]
KEGGiath:AT3G23050.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIAA7_ARATH
AccessioniPrimary (citable) accession number: Q38825
Secondary accession number(s): Q8LAK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families