Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Auxin-responsive protein IAA7

Gene

IAA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.1 Publication

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • auxin-activated signaling pathway Source: UniProtKB-KW
  • gravitropism Source: TAIR
  • response to auxin Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to water deprivation Source: TAIR
  • response to wounding Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processAuxin signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin-responsive protein IAA7
Alternative name(s):
Auxin resistant 2
Indoleacetic acid-induced protein 7
Gene namesi
Name:IAA7
Synonyms:AXR2
Ordered Locus Names:At3g23050
ORF Names:MXC7.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G23050
TAIRilocus:2094598 AT3G23050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87P → S in axr2-1; gain of function. Affects auxin-related developmental processes. Affects photomorphogenesis. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128381 – 243Auxin-responsive protein IAA7Add BLAST243

Proteomic databases

PaxDbiQ38825

Expressioni

Tissue specificityi

Highly expressed in stems and flowers.1 Publication

Inductioni

By auxin.1 Publication

Gene expression databases

ExpressionAtlasiQ38825 baseline and differential
GenevisibleiQ38825 AT

Interactioni

Subunit structurei

Homodimers and heterodimers.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi7211, 40 interactors
DIPiDIP-33345N
ELMiQ38825
IntActiQ38825, 42 interactors
STRINGi3702.AT3G23050.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P1NX-ray2.50C/F82-94[»]
2P1OX-ray1.90C82-94[»]
2P1QX-ray1.91C82-94[»]
ProteinModelPortaliQ38825
SMRiQ38825
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ38825

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 224PB1PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 17EAR-like (transcriptional repression)5

Domaini

The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.

Sequence similaritiesi

Belongs to the Aux/IAA family.Curated

Phylogenomic databases

eggNOGiENOG410IK8Z Eukaryota
ENOG410YEC3 LUCA
HOGENOMiHOG000238261
InParanoidiQ38825
KOiK14484
OMAiWEMFVNS
OrthoDBiEOG09360QD8
PhylomeDBiQ38825

Family and domain databases

InterProiView protein in InterPro
IPR033389 AUX/IAA_dom
IPR003311 AUX_IAA
IPR000270 PB1_dom
PANTHERiPTHR31734 PTHR31734, 1 hit
PfamiView protein in Pfam
PF02309 AUX_IAA, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q38825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIGQLMNLKA TELCLGLPGG AEAVESPAKS AVGSKRGFSE TVDLMLNLQS
60 70 80 90 100
NKEGSVDLKN VSAVPKEKTT LKDPSKPPAK AQVVGWPPVR NYRKNMMTQQ
110 120 130 140 150
KTSSGAEEAS SEKAGNFGGG AAGAGLVKVS MDGAPYLRKV DLKMYKSYQD
160 170 180 190 200
LSDALAKMFS SFTMGNYGAQ GMIDFMNESK LMNLLNSSEY VPSYEDKDGD
210 220 230 240
WMLVGDVPWE MFVESCKRLR IMKGSEAVGL APRAMEKYCK NRS
Length:243
Mass (Da):26,381
Last modified:November 1, 1996 - v1
Checksum:i830E9B9EA2C2B5D0
GO

Sequence cautioni

The sequence AAM65301 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228V → I in AAM65301 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18409 mRNA Translation: AAC49048.1
AB026655 Genomic DNA Translation: BAB02096.1
CP002686 Genomic DNA Translation: AEE76710.1
AF332395 mRNA Translation: AAG48759.1
AY054651 mRNA Translation: AAK96842.1
AY072461 mRNA Translation: AAL66876.1
AY087765 mRNA Translation: AAM65301.1 Different initiation.
PIRiS58494
RefSeqiNP_188945.1, NM_113205.3 [Q38825-1]
UniGeneiAt.22260
At.67783

Genome annotation databases

EnsemblPlantsiAT3G23050.1; AT3G23050.1; AT3G23050 [Q38825-1]
GeneIDi821879
GrameneiAT3G23050.1; AT3G23050.1; AT3G23050 [Q38825-1]
KEGGiath:AT3G23050

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIAA7_ARATH
AccessioniPrimary (citable) accession number: Q38825
Secondary accession number(s): Q8LAK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health