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Protein

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

PP2AB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Short name:
AtB alpha
Short name:
PP2A, subunit B, alpha isoform
Gene namesi
Name:PP2AB1
Ordered Locus Names:At1g51690
ORF Names:F19C24.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G51690.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPRO_0000071438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38821.
PRIDEiQ38821.

PTM databases

iPTMnetiQ38821.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasiQ38821. baseline and differential.
GenevisibleiQ38821. AT.

Interactioni

Subunit structurei

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).By similarity

Protein-protein interaction databases

BioGridi26819. 3 interactions.
STRINGi3702.AT1G51690.3.

Structurei

3D structure databases

ProteinModelPortaliQ38821.
SMRiQ38821. Positions 18-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 7540WD 1Add
BLAST
Repeati112 – 15342WD 2Add
BLAST
Repeati232 – 27039WD 3Add
BLAST
Repeati281 – 32141WD 4Add
BLAST
Repeati340 – 37839WD 5Add
BLAST
Repeati483 – 51331WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ38821.
KOiK04354.
PhylomeDBiQ38821.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDEVVAA SADPSLPLEW RFSQVFGERS AGEEVQEVDI ISAIEFDNSG
60 70 80 90 100
NHLATGDRGG RVVLFERTDT NNSSGTRREL EEADYPLRHP EFRYKTEFQS
110 120 130 140 150
HDPEFDYLKS LEIEEKINKI RWCQTANGAL FLLSTNDKTI KFWKVQDKKI
160 170 180 190 200
KKICDMNSDP SRTVGNGTVA SSSNSNITNS CLVNGGVSEV NNSLCNDFSL
210 220 230 240 250
PAGGISSLRL PVVVTSHESS PVARCRRVYA HAHDYHINSI SNNSDGETFI
260 270 280 290 300
SADDLRINLW NLEISNQSFN IVDVKPAKME DLSEVITSAE FHPTHCNMLA
310 320 330 340 350
YSSSKGSIRL IDLRQSALCD SHSKLFEEPE QAGPKSFFTE IIASVSDIKF
360 370 380 390 400
AKEGRYLLSR DYMTLKLWDI NMDAGPVATF QVHEYLKPKL CDLYENDSIF
410 420 430 440 450
DKFECCISGN GLRAATGSYS NLFRVFGVAP GSTETATLEA SRNPMRRHVP
460 470 480 490 500
IPSRPSRALS SITRVVSRGS ESPGVDGNTN ALDYTTKLLH LAWHPNENSI
510
ACAAANSLYM YYA
Length:513
Mass (Da):56,935
Last modified:January 24, 2006 - v2
Checksum:i2AF84BE214172D19
GO
Isoform 2 (identifier: Q38821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-214: Missing.

Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:512
Mass (Da):56,835
Checksum:iAEEDB6C986451503
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651G → R in AAA86695 (PubMed:7599311).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei214 – 2141Missing in isoform 2. CuratedVSP_025610

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18129 mRNA. Translation: AAA86695.1.
AC025294 Genomic DNA. Translation: AAG50878.1.
CP002684 Genomic DNA. Translation: AEE32701.1.
CP002684 Genomic DNA. Translation: AEE32702.1.
AY120756 mRNA. Translation: AAM53314.1.
BT000109 mRNA. Translation: AAN15428.1.
AK230310 mRNA. Translation: BAF02111.1.
PIRiG96555.
S55889.
RefSeqiNP_564595.1. NM_104047.3. [Q38821-1]
NP_974003.1. NM_202274.2. [Q38821-2]
UniGeneiAt.1589.

Genome annotation databases

EnsemblPlantsiAT1G51690.1; AT1G51690.1; AT1G51690. [Q38821-1]
GeneIDi841594.
KEGGiath:AT1G51690.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18129 mRNA. Translation: AAA86695.1.
AC025294 Genomic DNA. Translation: AAG50878.1.
CP002684 Genomic DNA. Translation: AEE32701.1.
CP002684 Genomic DNA. Translation: AEE32702.1.
AY120756 mRNA. Translation: AAM53314.1.
BT000109 mRNA. Translation: AAN15428.1.
AK230310 mRNA. Translation: BAF02111.1.
PIRiG96555.
S55889.
RefSeqiNP_564595.1. NM_104047.3. [Q38821-1]
NP_974003.1. NM_202274.2. [Q38821-2]
UniGeneiAt.1589.

3D structure databases

ProteinModelPortaliQ38821.
SMRiQ38821. Positions 18-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26819. 3 interactions.
STRINGi3702.AT1G51690.3.

PTM databases

iPTMnetiQ38821.

Proteomic databases

PaxDbiQ38821.
PRIDEiQ38821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G51690.1; AT1G51690.1; AT1G51690. [Q38821-1]
GeneIDi841594.
KEGGiath:AT1G51690.

Organism-specific databases

TAIRiAT1G51690.

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
HOGENOMiHOG000089745.
InParanoidiQ38821.
KOiK04354.
PhylomeDBiQ38821.

Enzyme and pathway databases

ReactomeiR-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ38821.

Gene expression databases

ExpressionAtlasiQ38821. baseline and differential.
GenevisibleiQ38821. AT.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PfamiPF00400. WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cDNA encoding the 55 kDa B regulatory subunit of Arabidopsis protein phosphatase 2A."
    Rundle S.J., Hartung A.J., Corum J.W. III, O'Neill M.
    Plant Mol. Biol. 28:257-266(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  6. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
    Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
    J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: cv. Columbia.

Entry informationi

Entry namei2ABA_ARATH
AccessioniPrimary (citable) accession number: Q38821
Secondary accession number(s): Q0WL96
, Q27GN0, Q8L842, Q9C8H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.