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Protein

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

PP2AB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-ATH-69231 Cyclin D associated events in G1
R-ATH-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-ATH-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Short name:
AtB alpha
Short name:
PP2A, subunit B, alpha isoform
Gene namesi
Name:PP2AB1
Ordered Locus Names:At1g51690
ORF Names:F19C24.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G51690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714381 – 513Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38821
PRIDEiQ38821

PTM databases

iPTMnetiQ38821

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

ExpressionAtlasiQ38821 baseline and differential
GenevisibleiQ38821 AT

Interactioni

Subunit structurei

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) (By similarity). Interacts with SIC/RON3 (PubMed:26888284).By similarity1 Publication

Protein-protein interaction databases

BioGridi26819, 3 interactors
STRINGi3702.AT1G51690.3

Structurei

3D structure databases

ProteinModelPortaliQ38821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati112 – 153WD 2Add BLAST42
Repeati232 – 270WD 3Add BLAST39
Repeati281 – 321WD 4Add BLAST41
Repeati340 – 378WD 5Add BLAST39
Repeati483 – 513WD 6Add BLAST31

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
HOGENOMiHOG000089745
InParanoidiQ38821
KOiK04354
PhylomeDBiQ38821

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGDEVVAA SADPSLPLEW RFSQVFGERS AGEEVQEVDI ISAIEFDNSG
60 70 80 90 100
NHLATGDRGG RVVLFERTDT NNSSGTRREL EEADYPLRHP EFRYKTEFQS
110 120 130 140 150
HDPEFDYLKS LEIEEKINKI RWCQTANGAL FLLSTNDKTI KFWKVQDKKI
160 170 180 190 200
KKICDMNSDP SRTVGNGTVA SSSNSNITNS CLVNGGVSEV NNSLCNDFSL
210 220 230 240 250
PAGGISSLRL PVVVTSHESS PVARCRRVYA HAHDYHINSI SNNSDGETFI
260 270 280 290 300
SADDLRINLW NLEISNQSFN IVDVKPAKME DLSEVITSAE FHPTHCNMLA
310 320 330 340 350
YSSSKGSIRL IDLRQSALCD SHSKLFEEPE QAGPKSFFTE IIASVSDIKF
360 370 380 390 400
AKEGRYLLSR DYMTLKLWDI NMDAGPVATF QVHEYLKPKL CDLYENDSIF
410 420 430 440 450
DKFECCISGN GLRAATGSYS NLFRVFGVAP GSTETATLEA SRNPMRRHVP
460 470 480 490 500
IPSRPSRALS SITRVVSRGS ESPGVDGNTN ALDYTTKLLH LAWHPNENSI
510
ACAAANSLYM YYA
Length:513
Mass (Da):56,935
Last modified:January 24, 2006 - v2
Checksum:i2AF84BE214172D19
GO
Isoform 2 (identifier: Q38821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-214: Missing.

Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:512
Mass (Da):56,835
Checksum:iAEEDB6C986451503
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165G → R in AAA86695 (PubMed:7599311).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025610214Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18129 mRNA Translation: AAA86695.1
AC025294 Genomic DNA Translation: AAG50878.1
CP002684 Genomic DNA Translation: AEE32701.1
CP002684 Genomic DNA Translation: AEE32702.1
CP002684 Genomic DNA Translation: ANM60211.1
AY120756 mRNA Translation: AAM53314.1
BT000109 mRNA Translation: AAN15428.1
AK230310 mRNA Translation: BAF02111.1
PIRiG96555
S55889
RefSeqiNP_001322512.1, NM_001333494.1 [Q38821-1]
NP_564595.1, NM_104047.4 [Q38821-1]
NP_974003.1, NM_202274.2 [Q38821-2]
UniGeneiAt.1589

Genome annotation databases

EnsemblPlantsiAT1G51690.1; AT1G51690.1; AT1G51690 [Q38821-1]
AT1G51690.2; AT1G51690.2; AT1G51690 [Q38821-2]
AT1G51690.4; AT1G51690.4; AT1G51690 [Q38821-1]
GeneIDi841594
GrameneiAT1G51690.1; AT1G51690.1; AT1G51690 [Q38821-1]
AT1G51690.2; AT1G51690.2; AT1G51690 [Q38821-2]
AT1G51690.4; AT1G51690.4; AT1G51690 [Q38821-1]
KEGGiath:AT1G51690

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei2ABA_ARATH
AccessioniPrimary (citable) accession number: Q38821
Secondary accession number(s): Q0WL96
, Q27GN0, Q8L842, Q9C8H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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