Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q38821 (2ABA_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Short name=AtB alpha
Short name=PP2A, subunit B, alpha isoform
Gene names
Name:PP2AB1
Ordered Locus Names:At1g51690
ORF Names:F19C24.10
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

Subunit structure

PP2A consists of a common heteromeric enzyme, composed of a catalytic subunit (subunits C), a constant regulatory subunit (subunit A), and a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) By similarity.

Tissue specificity

Expressed ubiquitously. Ref.1

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 6 WD repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentprotein phosphatase type 2A complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein phosphatase type 2A regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q38821-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q38821-2)

The sequence of this isoform differs from the canonical sequence as follows:
     214-214: Missing.
Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PRO_0000071438

Regions

Repeat36 – 7540WD 1
Repeat112 – 15342WD 2
Repeat232 – 27039WD 3
Repeat281 – 32141WD 4
Repeat340 – 37839WD 5
Repeat483 – 51331WD 6

Amino acid modifications

Modified residue4601Phosphoserine Ref.6

Natural variations

Alternative sequence2141Missing in isoform 2.
VSP_025610

Experimental info

Sequence conflict1651G → R in AAA86695. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 24, 2006. Version 2.
Checksum: 2AF84BE214172D19

FASTA51356,935
        10         20         30         40         50         60 
MNGGDEVVAA SADPSLPLEW RFSQVFGERS AGEEVQEVDI ISAIEFDNSG NHLATGDRGG 

        70         80         90        100        110        120 
RVVLFERTDT NNSSGTRREL EEADYPLRHP EFRYKTEFQS HDPEFDYLKS LEIEEKINKI 

       130        140        150        160        170        180 
RWCQTANGAL FLLSTNDKTI KFWKVQDKKI KKICDMNSDP SRTVGNGTVA SSSNSNITNS 

       190        200        210        220        230        240 
CLVNGGVSEV NNSLCNDFSL PAGGISSLRL PVVVTSHESS PVARCRRVYA HAHDYHINSI 

       250        260        270        280        290        300 
SNNSDGETFI SADDLRINLW NLEISNQSFN IVDVKPAKME DLSEVITSAE FHPTHCNMLA 

       310        320        330        340        350        360 
YSSSKGSIRL IDLRQSALCD SHSKLFEEPE QAGPKSFFTE IIASVSDIKF AKEGRYLLSR 

       370        380        390        400        410        420 
DYMTLKLWDI NMDAGPVATF QVHEYLKPKL CDLYENDSIF DKFECCISGN GLRAATGSYS 

       430        440        450        460        470        480 
NLFRVFGVAP GSTETATLEA SRNPMRRHVP IPSRPSRALS SITRVVSRGS ESPGVDGNTN 

       490        500        510 
ALDYTTKLLH LAWHPNENSI ACAAANSLYM YYA

« Hide

Isoform 2 [UniParc].

Checksum: AEEDB6C986451503
Show »

FASTA51256,835

References

« Hide 'large scale' references
[1]"Characterization of a cDNA encoding the 55 kDa B regulatory subunit of Arabidopsis protein phosphatase 2A."
Rundle S.J., Hartung A.J., Corum J.W. III, O'Neill M.
Plant Mol. Biol. 28:257-266(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[5]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[6]"Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, MASS SPECTROMETRY.
Strain: cv. Columbia.
Tissue: Seedling.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18129 mRNA. Translation: AAA86695.1.
AC025294 Genomic DNA. Translation: AAG50878.1.
CP002684 Genomic DNA. Translation: AEE32701.1.
CP002684 Genomic DNA. Translation: AEE32702.1.
AY120756 mRNA. Translation: AAM53314.1.
BT000109 mRNA. Translation: AAN15428.1.
AK230310 mRNA. Translation: BAF02111.1.
IPIIPI00528047.
IPI00543832.
PIRG96555.
S55889.
RefSeqNP_564595.1. NM_104047.3.
NP_974003.1. NM_202274.2.
UniGeneAt.1589.

3D structure databases

ProteinModelPortalQ38821.
SMRQ38821. Positions 18-511.
ModBaseSearch...

Protein-protein interaction databases

STRING3702.AT1G51690.1-P.

Proteomic databases

PaxDbQ38821.
PRIDEQ38821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G51690.1; AT1G51690.1; AT1G51690.
GeneID841594.
KEGGath:AT1G51690.

Organism-specific databases

GeneFarm3008. 267.
TAIRAt1g51690.

Phylogenomic databases

eggNOGCOG5170.
HOGENOMHOG000089745.
InParanoidQ38821.
KOK04354.
PhylomeDBQ38821.
ProtClustDBCLSN2687843.

Gene expression databases

ArrayExpressQ38821.
GenevestigatorQ38821.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR11871. PTHR11871. 1 hit.
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name2ABA_ARATH
AccessionPrimary (citable) accession number: Q38821
Secondary accession number(s): Q0WL96 expand/collapse secondary AC list , Q27GN0, Q8L842, Q9C8H8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents