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Protein

Cyclin-A2-3

Gene

CYCA2-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication (PubMed:16415207). Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division (PubMed:24687979).2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: TAIR
  • DNA endoreduplication Source: TAIR
  • guard mother cell differentiation Source: UniProtKB
  • lateral root formation Source: TAIR
  • positive regulation of stomatal complex development Source: TAIR
  • regulation of G2/M transition of mitotic cell cycle Source: TAIR

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-1538133 G0 and Early G1
R-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-ATH-5689880 Ub-specific processing proteases
R-ATH-5693607 Processing of DNA double-strand break ends
R-ATH-68911 G2 Phase
R-ATH-68949 Orc1 removal from chromatin
R-ATH-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-ATH-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2-3
Alternative name(s):
Cyc3c-At
Cyclin-3c
G2/mitotic-specific cyclin-A2-3
Short name:
CycA2;3
Gene namesi
Name:CYCA2-3
Synonyms:CYC3C
Ordered Locus Names:At1g15570
ORF Names:T16N11.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G15570
TAIRilocus:2196563 AT1G15570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869951 – 450Cyclin-A2-3Add BLAST450

Proteomic databases

PaxDbiQ38819

Expressioni

Inductioni

Repressed by MYB88 and MYB124 in newly formed guard cells.1 Publication

Gene expression databases

ExpressionAtlasiQ38819 baseline and differential
GenevisibleiQ38819 AT

Interactioni

Subunit structurei

Interacts with CDKA-1 (PubMed:16415207). Interacts with SAMBA (PubMed:22869741).2 Publications

Protein-protein interaction databases

BioGridi23367, 32 interactors
IntActiQ38819, 25 interactors
STRINGi3702.AT1G15570.1

Structurei

3D structure databases

ProteinModelPortaliQ38819
SMRiQ38819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
HOGENOMiHOG000167672
InParanoidiQ38819
KOiK06627
OMAiPRRELEC
OrthoDBiEOG09360C5F
PhylomeDBiQ38819

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequencei

Sequence statusi: Complete.

Q38819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKENAVSRP FTRSLASALR ASEVTSTTQN QQRVNTKRPA LEDTRATGPN
60 70 80 90 100
KRKKRAVLGE ITNVNSNTAI LEAKNSKQIK KGRGHGLAST SQLATSVTSE
110 120 130 140 150
VTDLQSRTDA KVEVASNTAG NLSVSKGTDN TADNCIEIWN SRLPPRPLGR
160 170 180 190 200
SASTAEKSAV IGSSTVPDIP KFVDIDSDDK DPLLCCLYAP EIHYNLRVSE
210 220 230 240 250
LKRRPLPDFM ERIQKDVTQS MRGILVDWLV EVSEEYTLAS DTLYLTVYLI
260 270 280 290 300
DWFLHGNYVQ RQQLQLLGIT CMLIASKYEE ISAPRIEEFC FITDNTYTRD
310 320 330 340 350
QVLEMENQVL KHFSFQIYTP TPKTFLRRFL RAAQASRLSP SLEVEFLASY
360 370 380 390 400
LTELTLIDYH FLKFLPSVVA ASAVFLAKWT MDQSNHPWNP TLEHYTTYKA
410 420 430 440 450
SDLKASVHAL QDLQLNTKGC PLSAIRMKYR QEKYKSVAVL TSPKLLDTLF
Length:450
Mass (Da):50,642
Last modified:May 15, 2007 - v2
Checksum:i8EF3B638843CD478
GO

Sequence cautioni

The sequence AAF71982 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299R → E in AAA90946 (Ref. 4) Curated1
Sequence conflicti325F → S in AAA90946 (Ref. 4) Curated1
Sequence conflicti343E → G in AAA90946 (Ref. 4) Curated1
Sequence conflicti355T → A in AAA90946 (Ref. 4) Curated1
Sequence conflicti359Y → C in AAA90946 (Ref. 4) Curated1
Sequence conflicti385N → T in AAA90946 (Ref. 4) Curated1
Sequence conflicti393E → D in AAA90946 (Ref. 4) Curated1
Sequence conflicti400A → P in AAA90946 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA Translation: AAF71982.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29336.1
AY072105 mRNA Translation: AAL59927.1
AY096733 mRNA Translation: AAM20367.1
U17890 mRNA Translation: AAA90946.1
PIRiF86289
S71193
RefSeqiNP_173010.1, NM_101426.5
UniGeneiAt.1679

Genome annotation databases

EnsemblPlantsiAT1G15570.1; AT1G15570.1; AT1G15570
GeneIDi838127
GrameneiAT1G15570.1; AT1G15570.1; AT1G15570
KEGGiath:AT1G15570

Similar proteinsi

Entry informationi

Entry nameiCCA23_ARATH
AccessioniPrimary (citable) accession number: Q38819
Secondary accession number(s): Q8VYG1, Q9M9D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health