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Protein

Cyclin-A2-3

Gene

CYCA2-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication (PubMed:16415207). Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division (PubMed:24687979).2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: TAIR
  • DNA endoreduplication Source: TAIR
  • guard mother cell differentiation Source: UniProtKB
  • lateral root formation Source: TAIR
  • positive regulation of stomatal complex development Source: TAIR
  • regulation of G2/M transition of mitotic cell cycle Source: TAIR

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-5689880. Ub-specific processing proteases.
R-ATH-5693607. Processing of DNA double-strand break ends.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2-3
Alternative name(s):
Cyc3c-At
Cyclin-3c
G2/mitotic-specific cyclin-A2-3
Short name:
CycA2;3
Gene namesi
Name:CYCA2-3
Synonyms:CYC3C
Ordered Locus Names:At1g15570
ORF Names:T16N11.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRilocus:2196563. AT1G15570.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869951 – 450Cyclin-A2-3Add BLAST450

Proteomic databases

PaxDbiQ38819.

Expressioni

Inductioni

Repressed by MYB88 and MYB124 in newly formed guard cells.1 Publication

Gene expression databases

ExpressionAtlasiQ38819. baseline and differential.
GenevisibleiQ38819. AT.

Interactioni

Subunit structurei

Interacts with CDKA-1.1 Publication

Protein-protein interaction databases

BioGridi23367. 32 interactors.
IntActiQ38819. 25 interactors.
STRINGi3702.AT1G15570.1.

Structurei

3D structure databases

ProteinModelPortaliQ38819.
SMRiQ38819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ38819.
KOiK06627.
OMAiLAKWTMD.
OrthoDBiEOG09360C5F.
PhylomeDBiQ38819.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

Q38819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKENAVSRP FTRSLASALR ASEVTSTTQN QQRVNTKRPA LEDTRATGPN
60 70 80 90 100
KRKKRAVLGE ITNVNSNTAI LEAKNSKQIK KGRGHGLAST SQLATSVTSE
110 120 130 140 150
VTDLQSRTDA KVEVASNTAG NLSVSKGTDN TADNCIEIWN SRLPPRPLGR
160 170 180 190 200
SASTAEKSAV IGSSTVPDIP KFVDIDSDDK DPLLCCLYAP EIHYNLRVSE
210 220 230 240 250
LKRRPLPDFM ERIQKDVTQS MRGILVDWLV EVSEEYTLAS DTLYLTVYLI
260 270 280 290 300
DWFLHGNYVQ RQQLQLLGIT CMLIASKYEE ISAPRIEEFC FITDNTYTRD
310 320 330 340 350
QVLEMENQVL KHFSFQIYTP TPKTFLRRFL RAAQASRLSP SLEVEFLASY
360 370 380 390 400
LTELTLIDYH FLKFLPSVVA ASAVFLAKWT MDQSNHPWNP TLEHYTTYKA
410 420 430 440 450
SDLKASVHAL QDLQLNTKGC PLSAIRMKYR QEKYKSVAVL TSPKLLDTLF
Length:450
Mass (Da):50,642
Last modified:May 15, 2007 - v2
Checksum:i8EF3B638843CD478
GO

Sequence cautioni

The sequence AAF71982 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299R → E in AAA90946 (Ref. 4) Curated1
Sequence conflicti325F → S in AAA90946 (Ref. 4) Curated1
Sequence conflicti343E → G in AAA90946 (Ref. 4) Curated1
Sequence conflicti355T → A in AAA90946 (Ref. 4) Curated1
Sequence conflicti359Y → C in AAA90946 (Ref. 4) Curated1
Sequence conflicti385N → T in AAA90946 (Ref. 4) Curated1
Sequence conflicti393E → D in AAA90946 (Ref. 4) Curated1
Sequence conflicti400A → P in AAA90946 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA. Translation: AAF71982.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29336.1.
AY072105 mRNA. Translation: AAL59927.1.
AY096733 mRNA. Translation: AAM20367.1.
U17890 mRNA. Translation: AAA90946.1.
PIRiF86289.
S71193.
RefSeqiNP_173010.1. NM_101426.5.
UniGeneiAt.1679.

Genome annotation databases

EnsemblPlantsiAT1G15570.1; AT1G15570.1; AT1G15570.
GeneIDi838127.
GrameneiAT1G15570.1; AT1G15570.1; AT1G15570.
KEGGiath:AT1G15570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA. Translation: AAF71982.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29336.1.
AY072105 mRNA. Translation: AAL59927.1.
AY096733 mRNA. Translation: AAM20367.1.
U17890 mRNA. Translation: AAA90946.1.
PIRiF86289.
S71193.
RefSeqiNP_173010.1. NM_101426.5.
UniGeneiAt.1679.

3D structure databases

ProteinModelPortaliQ38819.
SMRiQ38819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23367. 32 interactors.
IntActiQ38819. 25 interactors.
STRINGi3702.AT1G15570.1.

Proteomic databases

PaxDbiQ38819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G15570.1; AT1G15570.1; AT1G15570.
GeneIDi838127.
GrameneiAT1G15570.1; AT1G15570.1; AT1G15570.
KEGGiath:AT1G15570.

Organism-specific databases

AraportiAT1G15570.
TAIRilocus:2196563. AT1G15570.

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ38819.
KOiK06627.
OMAiLAKWTMD.
OrthoDBiEOG09360C5F.
PhylomeDBiQ38819.

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-5689880. Ub-specific processing proteases.
R-ATH-5693607. Processing of DNA double-strand break ends.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Miscellaneous databases

PROiQ38819.

Gene expression databases

ExpressionAtlasiQ38819. baseline and differential.
GenevisibleiQ38819. AT.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCA23_ARATH
AccessioniPrimary (citable) accession number: Q38819
Secondary accession number(s): Q8VYG1, Q9M9D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 15, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.