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Protein

Metallothionein-like protein 2B

Gene

MT2B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Functions cooperatively with the phytochelatin synthase PCS1 to protect plants from Cu and cadmium toxicity (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746).Curated2 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 2B
Short name:
MT-2B
Gene namesi
Name:MT2B
Ordered Locus Names:At5g02380
ORF Names:T1E22_140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G02380.
TAIRilocus:2180132. AT5G02380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973871 – 77Metallothionein-like protein 2BAdd BLAST77

Proteomic databases

PaxDbiQ38805.

Expressioni

Tissue specificityi

Expressed in vascular tissues of all organs. Expressed in root and leaf phloem, pollen and root hairs.1 Publication

Gene expression databases

GenevisibleiQ38805. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G02380.1.

Structurei

3D structure databases

ProteinModelPortaliQ38805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
HOGENOMiHOG000220916.
InParanoidiQ38805.
OMAiHLAGSEM.
OrthoDBiEOG0936118M.
PhylomeDBiQ38805.

Family and domain databases

InterProiView protein in InterPro
IPR000347. Metalthion_15p.
PfamiView protein in Pfam
PF01439. Metallothio_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCCGGSCGC GSACKCGNGC GGCKRYPDLE NTATETLVLG VAPAMNSQYE
60 70
ASGETFVAEN DACKCGSDCK CNPCTCK
Length:77
Mass (Da):7,766
Last modified:November 1, 1996 - v1
Checksum:iB67CB2277F8EFFB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27P → S in AAM62956 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11256 Genomic DNA. Translation: AAA82212.1.
AL162874 Genomic DNA. Translation: CAB85543.1.
CP002688 Genomic DNA. Translation: AED90465.1.
AF324665 mRNA. Translation: AAG40016.1.
AF339712 mRNA. Translation: AAK00394.1.
BT004570 mRNA. Translation: AAO42816.1.
AK227568 mRNA. Translation: BAE99562.1.
AY085738 mRNA. Translation: AAM62956.1.
PIRiS57862.
RefSeqiNP_195858.1. NM_120316.2.
UniGeneiAt.20086.
At.20468.
At.20592.
At.26254.
At.48845.
At.48973.
At.73025.

Genome annotation databases

EnsemblPlantsiAT5G02380.1; AT5G02380.1; AT5G02380.
GeneIDi831816.
GrameneiAT5G02380.1; AT5G02380.1; AT5G02380.
KEGGiath:AT5G02380.

Similar proteinsi

Entry informationi

Entry nameiMT2B_ARATH
AccessioniPrimary (citable) accession number: Q38805
Secondary accession number(s): Q0WTI6, Q8LDX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families