ID   MT1C_ARATH              Reviewed;          45 AA.
AC   Q38804;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=Metallothionein-like protein 1C;
DE            Short=MT-1C;
GN   Name=MT1C; OrderedLocusNames=At1g07610; ORFNames=F22G5_34, F24B9.33;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=7565594; DOI=10.1007/bf02191599;
RA   Zhou J., Goldsbrough P.B.;
RT   "Structure, organization and expression of the metallothionein gene family
RT   in Arabidopsis.";
RL   Mol. Gen. Genet. 248:318-328(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION.
RX   PubMed=16240177; DOI=10.1007/s11103-005-8268-3;
RA   Zimeri A.M., Dhankher O.P., McCaig B., Meagher R.B.;
RT   "The plant MT1 metallothioneins are stabilized by binding cadmiums and are
RT   required for cadmium tolerance and accumulation.";
RL   Plant Mol. Biol. 58:839-855(2005).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=22014117; DOI=10.1111/j.1365-3040.2011.02450.x;
RA   Ren Y., Liu Y., Chen H., Li G., Zhang X., Zhao J.;
RT   "Type 4 metallothionein genes are involved in regulating Zn ion
RT   accumulation in late embryo and in controlling early seedling growth in
RT   Arabidopsis.";
RL   Plant Cell Environ. 35:770-789(2012).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC       that bind various heavy metals (Probable). Confers tolerance to cadmium
CC       (Cd) and plays a role in Cd and zinc (Zn) homeostasis
CC       (PubMed:16240177). {ECO:0000269|PubMed:16240177, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Widely expressed at low levels.
CC       {ECO:0000269|PubMed:22014117}.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 15 family.
CC       {ECO:0000305}.
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DR   EMBL; U11255; AAA82211.1; -; Genomic_DNA.
DR   EMBL; AC007583; AAF75097.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE28148.1; -; Genomic_DNA.
DR   EMBL; AF375400; AAK52984.1; -; mRNA.
DR   EMBL; AY142056; AAM98320.1; -; mRNA.
DR   EMBL; AY085074; AAM61630.1; -; mRNA.
DR   PIR; S57860; S57860.
DR   RefSeq; NP_172240.1; NM_100634.2.
DR   AlphaFoldDB; Q38804; -.
DR   STRING; 3702.Q38804; -.
DR   EnsemblPlants; AT1G07610.1; AT1G07610.1; AT1G07610.
DR   GeneID; 837274; -.
DR   Gramene; AT1G07610.1; AT1G07610.1; AT1G07610.
DR   KEGG; ath:AT1G07610; -.
DR   Araport; AT1G07610; -.
DR   TAIR; AT1G07610; MT1C.
DR   eggNOG; KOG4738; Eukaryota.
DR   HOGENOM; CLU_3208289_0_0_1; -.
DR   InParanoid; Q38804; -.
DR   PRO; PR:Q38804; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q38804; baseline and differential.
DR   GO; GO:0022626; C:cytosolic ribosome; HDA:TAIR.
DR   GO; GO:0005507; F:copper ion binding; ISS:TAIR.
DR   GO; GO:0046688; P:response to copper ion; ISS:TAIR.
DR   Genevisible; Q38804; AT.
PE   2: Evidence at transcript level;
KW   Metal-binding; Metal-thiolate cluster; Reference proteome.
FT   CHAIN           1..45
FT                   /note="Metallothionein-like protein 1C"
FT                   /id="PRO_0000197421"
SQ   SEQUENCE   45 AA;  4495 MW;  B8AD2F783C3C25D2 CRC64;
     MAGSNCGCGS SCKCGDSCSC EKNYNKECDN CSCGSNCSCG SSCNC
//