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Protein

Cell division control protein 2 homolog D

Gene

CDC2D

Organism
Antirrhinum majus (Garden snapdragon)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATPPROSITE-ProRule annotation1
Active sitei145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 376.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog D (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CDC2D
OrganismiAntirrhinum majus (Garden snapdragon)
Taxonomic identifieri4151 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857481 – 312Cell division control protein 2 homolog DAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphothreonineBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei179Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Expression specific to the G2 and M phases.

Structurei

3D structure databases

ProteinModelPortaliQ38775.
SMRiQ38775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKSKSSA MDAFVKLEKV GEGTYGKVYR AMEKSTGKIV ALKKTRLHED
60 70 80 90 100
EEGVPPTTLR EVSLLRMLSR DPHVVRLLDV KQGQNKEGKT VLYLVFEYMD
110 120 130 140 150
TDLKKYIRSF KQTGESIAPM NVKSLMYQLC KGVAFCHGHG VLHRDLKPHN
160 170 180 190 200
LLMDRKTMML KIADLGLARA YTLPIKKYTH EILTLWYRAP EVLLGATHYS
210 220 230 240 250
PAVDMWSVAC IFAELVTQKA LFPGDSELQQ LLHIFRLLGT PNEEIWPGVS
260 270 280 290 300
TLVDWHEYPQ WTAQPISSAV PGLDEKGLNL LSEMLHYEPS RRISAKKAME
310
HPYFDELDKS GL
Length:312
Mass (Da):35,503
Last modified:November 1, 1996 - v1
Checksum:iA38D2177EBF70210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97640 mRNA. Translation: CAA66236.1.
PIRiT17118.

Similar proteinsi

Entry informationi

Entry nameiCDC2D_ANTMA
AccessioniPrimary (citable) accession number: Q38775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families