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Q38775

- CDC2D_ANTMA

UniProt

Q38775 - CDC2D_ANTMA

Protein

Cell division control protein 2 homolog D

Gene

CDC2D

Organism
Antirrhinum majus (Garden snapdragon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPPROSITE-ProRule annotation
    Active sitei145 – 1451Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 376.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 2 homolog D (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:CDC2D
    OrganismiAntirrhinum majus (Garden snapdragon)
    Taxonomic identifieri4151 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Cell division control protein 2 homolog DPRO_0000085748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphothreonineBy similarity
    Modified residuei25 – 251PhosphotyrosineBy similarity
    Modified residuei179 – 1791Phosphothreonine; by CAKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Developmental stagei

    Expression specific to the G2 and M phases.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 304291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q38775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEEKSKSSA MDAFVKLEKV GEGTYGKVYR AMEKSTGKIV ALKKTRLHED    50
    EEGVPPTTLR EVSLLRMLSR DPHVVRLLDV KQGQNKEGKT VLYLVFEYMD 100
    TDLKKYIRSF KQTGESIAPM NVKSLMYQLC KGVAFCHGHG VLHRDLKPHN 150
    LLMDRKTMML KIADLGLARA YTLPIKKYTH EILTLWYRAP EVLLGATHYS 200
    PAVDMWSVAC IFAELVTQKA LFPGDSELQQ LLHIFRLLGT PNEEIWPGVS 250
    TLVDWHEYPQ WTAQPISSAV PGLDEKGLNL LSEMLHYEPS RRISAKKAME 300
    HPYFDELDKS GL 312
    Length:312
    Mass (Da):35,503
    Last modified:November 1, 1996 - v1
    Checksum:iA38D2177EBF70210
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97640 mRNA. Translation: CAA66236.1.
    PIRiT17118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97640 mRNA. Translation: CAA66236.1 .
    PIRi T17118.

    3D structure databases

    ProteinModelPortali Q38775.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 376.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants."
      Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H.
      Plant Cell 8:1465-1476(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Flower.

    Entry informationi

    Entry nameiCDC2D_ANTMA
    AccessioniPrimary (citable) accession number: Q38775
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3