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Protein

Cell division control protein 2 homolog C

Gene

CDC2C

Organism
Antirrhinum majus (Garden snapdragon)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei138Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 376.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog C (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CDC2C
OrganismiAntirrhinum majus (Garden snapdragon)
Taxonomic identifieri4151 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857471 – 305Cell division control protein 2 homolog CAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei172Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

CDC2C transcripts accumulate during S phase as well as during the G2 and M transition.

Structurei

3D structure databases

ProteinModelPortaliQ38774.
SMRiQ38774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYEKLEKV GEGTYGKVYK ALEKSTGQVV ALKKTRLEMD EEGVPPTALR
60 70 80 90 100
EVSLLQMLSQ SLYVVRLLSV EHVDCAKNGK PLLYLVFEYL DTDLKKFIDS
110 120 130 140 150
HRKGPNPRPL PPQQIQSFLF QLCKGVSHCH AHGVLHRDLK PQNLLLDKDK
160 170 180 190 200
GVLKIADLGL ARAFTVPLKS YTHEIVTLSY RAPEVLLGSS HYSTAVDMSS
210 220 230 240 250
VGCIFAEMVR RQALFPGDSE FQQLLHIFRL LGTPSDEQWP GVSSLRDWHV
260 270 280 290 300
YPQWEPQNSA PAVPSLGPDG LDLLTKTLKY DPADRISAKA ALDHPYFDTL

DKSQF
Length:305
Mass (Da):34,298
Last modified:November 1, 1996 - v1
Checksum:iA8F577FB6DE72CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97639 mRNA. Translation: CAA66235.1.
PIRiT17117.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDC2C_ANTMA
AccessioniPrimary (citable) accession number: Q38774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families