Q38774 (CDC2C_ANTMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division control protein 2 homolog C
EC=2.7.11.22
EC=2.7.11.23

Gene names

Name:

CDC2C

Organism

Antirrhinum majus (Garden snapdragon)

Taxonomic identifier

4151 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Plantaginaceae › Antirrhineae › Antirrhinum

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in the control of the eukaryotic cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Developmental stage	CDC2C transcripts accumulate during S phase as well as during the G2 and M transition.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Cell division control protein 2 homolog C		PRO_0000085747
Regions
	Domain	4 – 297	294	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Amino acid modifications
	Modified residue	14	1	Phosphothreonine By similarity
	Modified residue	15	1	Phosphotyrosine By similarity
	Modified residue	172	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q38774 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A8F577FB6DE72CE7	FASTA	305	34,298
	10 20 30 40 50 60 MEKYEKLEKV GEGTYGKVYK ALEKSTGQVV ALKKTRLEMD EEGVPPTALR EVSLLQMLSQ 70 80 90 100 110 120 SLYVVRLLSV EHVDCAKNGK PLLYLVFEYL DTDLKKFIDS HRKGPNPRPL PPQQIQSFLF 130 140 150 160 170 180 QLCKGVSHCH AHGVLHRDLK PQNLLLDKDK GVLKIADLGL ARAFTVPLKS YTHEIVTLSY 190 200 210 220 230 240 RAPEVLLGSS HYSTAVDMSS VGCIFAEMVR RQALFPGDSE FQQLLHIFRL LGTPSDEQWP 250 260 270 280 290 300 GVSSLRDWHV YPQWEPQNSA PAVPSLGPDG LDLLTKTLKY DPADRISAKA ALDHPYFDTL DKSQF

References

[1]	"Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants." Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H. Plant Cell 8:1465-1476(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Flower.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97639 mRNA. Translation: CAA66235.1.
PIR	T17117.
3D structure databases
ProteinModelPortal	Q38774.
SMR	Q38774. Positions 1-303.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 376.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDC2C_ANTMA

Accession

Primary (citable) accession number: Q38774

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program