Q38773 (CDC2B_ANTMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division control protein 2 homolog B
EC=2.7.11.22
EC=2.7.11.23

Gene names

Name:

CDC2B

Organism

Antirrhinum majus (Garden snapdragon)

Taxonomic identifier

4151 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Plantaginaceae › Antirrhineae › Antirrhinum

Protein attributes

Sequence length	280 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in the control of the eukaryotic cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Enzyme regulation	Phosphorylation at Tyr-2 inactivates the enzyme, while phosphorylation at Thr-148 activates it By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 280	›280	Cell division control protein 2 homolog B		PRO_0000085746
Regions
	Domain	‹1 – 274	›274	Protein kinase
	Nucleotide binding	‹1 – 5	›5	ATP By similarity
Sites
	Active site	114	1	Proton acceptor By similarity
	Binding site	20	1	ATP By similarity
Amino acid modifications
	Modified residue	2	1	Phosphotyrosine By similarity
	Modified residue	148	1	Phosphothreonine; by CAK By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q38773 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB4F3715A4FFE6CC	FASTA	280	32,167
	10 20 30 40 50 60 AYGVVYKARD IETNEDIALK KIRLEQEDEG VPSTAIREIS LLKEMHHENI VNLKDVVHRE 70 80 90 100 110 120 KRLYLVFEYL DLDLKKHMDS CPEFSQDLHM VKMFLCQILR GVAYCHSHRV LHRDLKPQNL 130 140 150 160 170 180 LIDRGSNTIK LADFGLARAF GIPVRTFTHE VVTLWYRAPE VLLGSRHYST PVDVWSVGCI 190 200 210 220 230 240 FAEMVNQKPL FPGDSEIDEL HKIFRIIGTP NEDIWPGVTS LPDFKSSFPK WPPKELATIV 250 260 270 280 PNLGATGLDL LCKMLQLDPS KRITAKKALE HEYFKDIVLP

References

[1]	"Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants." Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H. Plant Cell 8:1465-1476(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Flower.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97638 mRNA. Translation: CAA66234.1.
PIR	T17116.
3D structure databases
ProteinModelPortal	Q38773.
SMR	Q38773. Positions 2-280.
ModBase	Search...
Proteomic databases
PRIDE	Q38773.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDC2B_ANTMA

Accession

Primary (citable) accession number: Q38773

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program