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Q38773

- CDC2B_ANTMA

UniProt

Q38773 - CDC2B_ANTMA

Protein

Cell division control protein 2 homolog B

Gene

CDC2B

Organism
Antirrhinum majus (Garden snapdragon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Enzyme regulationi

    Phosphorylation at Tyr-2 inactivates the enzyme, while phosphorylation at Thr-148 activates it.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201ATPPROSITE-ProRule annotation
    Active sitei114 – 1141Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi‹1 – 5›5ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 2 homolog B (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:CDC2B
    OrganismiAntirrhinum majus (Garden snapdragon)
    Taxonomic identifieri4151 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 280›280Cell division control protein 2 homolog BPRO_0000085746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21PhosphotyrosineBy similarity
    Modified residuei148 – 1481Phosphothreonine; by CAKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ38773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38773.
    SMRiQ38773. Positions 2-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 274›274Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q38773-1 [UniParc]FASTAAdd to Basket

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    AYGVVYKARD IETNEDIALK KIRLEQEDEG VPSTAIREIS LLKEMHHENI    50
    VNLKDVVHRE KRLYLVFEYL DLDLKKHMDS CPEFSQDLHM VKMFLCQILR 100
    GVAYCHSHRV LHRDLKPQNL LIDRGSNTIK LADFGLARAF GIPVRTFTHE 150
    VVTLWYRAPE VLLGSRHYST PVDVWSVGCI FAEMVNQKPL FPGDSEIDEL 200
    HKIFRIIGTP NEDIWPGVTS LPDFKSSFPK WPPKELATIV PNLGATGLDL 250
    LCKMLQLDPS KRITAKKALE HEYFKDIVLP 280
    Length:280
    Mass (Da):32,167
    Last modified:November 1, 1996 - v1
    Checksum:iEB4F3715A4FFE6CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97638 mRNA. Translation: CAA66234.1.
    PIRiT17116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97638 mRNA. Translation: CAA66234.1 .
    PIRi T17116.

    3D structure databases

    ProteinModelPortali Q38773.
    SMRi Q38773. Positions 2-280.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q38773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants."
      Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H.
      Plant Cell 8:1465-1476(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Flower.

    Entry informationi

    Entry nameiCDC2B_ANTMA
    AccessioniPrimary (citable) accession number: Q38773
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3