Reviewed, UniProtKB/Swiss-Prot Q38772 (CDC2A_ANTMA)

Names and origin

Protein names

Recommended name:
    Cell division control protein 2 homolog A
    EC=2.7.11.22
    EC=2.7.11.23

Gene names

Name:

CDC2A

Organism

Antirrhinum majus (Garden snapdragon)

Taxonomic identifier

4151 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Plantaginaceae › Antirrhineae › Antirrhinum

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a key role in the control of the eukaryotic cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Enzyme regulation	Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Cell division control protein 2 homolog A		PRO_0000085745
Regions
	Domain	4 – 287	284	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Amino acid modifications
	Modified residue	14	1	Phosphothreonine By similarity
	Modified residue	15	1	Phosphotyrosine By similarity
	Modified residue	161	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q38772-1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 0DD450ECD6FA166C	FASTA	294	33,912
	10 20 30 40 50 60 MEQYEKVEKI GEGTYGVVYK ARDRVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 70 80 90 100 110 120 GNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSCPEFSQD PRLVKMFLYQ ILRGIAYCHS 130 140 150 160 170 180 HRVLHRDLKP QNLLIDRRTN ALKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSRH 190 200 210 220 230 240 YSTPVDVWSV GCIFAEMVNQ RPLFPGDSEI DELFKIFRVM GTPNEETWPG VTSLPDFKSA 250 260 270 280 290 FPKWPAKELA AVVPNLDASG LDLLDKMLRL DPSKRITARN ALQHEYFKDI GFVP

References

[1]	"Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants." Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H. Plant Cell 8:1465-1476(1996) [PubMed: 8837502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97637 mRNA. Translation: CAA66233.1. Different initiation.
PIR	T17115.
3D structure databases
SMR	Q38772. Positions 1-290.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 189180. 2.7.11.23. 189180.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDC2A_ANTMA

Accession

Primary (citable) accession number: Q38772

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	January 19, 2010
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)