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Q38772

- CDC2A_ANTMA

UniProt

Q38772 - CDC2A_ANTMA

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Protein
Cell division control protein 2 homolog A
Gene
CDC2A
Organism
Antirrhinum majus (Garden snapdragon)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 376.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog A (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CDC2A
OrganismiAntirrhinum majus (Garden snapdragon)
Taxonomic identifieri4151 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cell division control protein 2 homolog A
PRO_0000085745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei161 – 1611Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ38772.

Structurei

3D structure databases

ProteinModelPortaliQ38772.
SMRiQ38772. Positions 1-290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinase
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q38772-1 [UniParc]FASTAAdd to Basket

« Hide

MEQYEKVEKI GEGTYGVVYK ARDRVTNETI ALKKIRLEQE DEGVPSTAIR    50
EISLLKEMQH GNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSCPEFSQD 100
PRLVKMFLYQ ILRGIAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA 150
RAFGIPVRTF THEVVTLWYR APEILLGSRH YSTPVDVWSV GCIFAEMVNQ 200
RPLFPGDSEI DELFKIFRVM GTPNEETWPG VTSLPDFKSA FPKWPAKELA 250
AVVPNLDASG LDLLDKMLRL DPSKRITARN ALQHEYFKDI GFVP 294
Length:294
Mass (Da):33,912
Last modified:July 15, 1999 - v2
Checksum:i0DD450ECD6FA166C
GO

Sequence cautioni

The sequence CAA66233.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97637 mRNA. Translation: CAA66233.1. Different initiation.
PIRiT17115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97637 mRNA. Translation: CAA66233.1 . Different initiation.
PIRi T17115.

3D structure databases

ProteinModelPortali Q38772.
SMRi Q38772. Positions 1-290.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q38772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.11.22. 376.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants."
    Fobert P.R., Gaudin V., Lunness P., Coen E.S., Doonan J.H.
    Plant Cell 8:1465-1476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCDC2A_ANTMA
AccessioniPrimary (citable) accession number: Q38772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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