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Protein
Submitted name:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Gene

Tb11.02.0120

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
UDP-N-acetylglucosamine pyrophosphorylase, putativeImported (EC:2.7.7.23Imported)
Gene namesi
ORF Names:Tb11.02.0120Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 11 Scaffold 1

Interactioni

Protein-protein interaction databases

STRINGi5691.Tb11.02.0120.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQHX-ray1.75A1-545[»]
ProteinModelPortaliQ386Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000186273.
InParanoidiQ386Q8.
KOiK00972.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q386Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRDVCIQR LTGANQDHIL TALEHGSEAE RASLTAQITN ELAGVDFRHF
60 70 80 90 100
NDVLRESLEI SKNCSTASLA EPPAKDSFFD ISSVDRRRGQ AKRIKNLEAV
110 120 130 140 150
GYKAIQKGQI AFLILAGGSG TRLGFDKPKG FFTCDGLQQR KSLFMMHCEK
160 170 180 190 200
IRRRQEIAES ISGSGRKARV QLLVMTSGQN DAETQRFFEE NSYFGLEREQ
210 220 230 240 250
VHFFAQSSVP CYDENTGRII MENRGRICAA PGGNGAVFAA LAAPRATKDK
260 270 280 290 300
DGTLQVKESL LQHLRKLGIA YVQIGNIDNL LANVADPVFI GYAIEEEAHV
310 320 330 340 350
VVKTCPKRGP DERVGVFVRA SGKWGVVEYT EIGDRAKEID DATGELKFNC
360 370 380 390 400
ANISSNLCSL HFMSLAAERM KSFTQYHAAR KKIPTIKGPV MGIKLEAFLF
410 420 430 440 450
DLFRFVDECD HPPKDSGAFR IMQVDRDDEF GPVKNADGAA SDTPADAVRL
460 470 480 490 500
LLSQHTRWLI TALETAAMSD EQESIRGGVD VTEAKEAVAV MRSCSIKAEI
510 520 530 540
SPLVSVGGEG LRQHLPRVIH QLLRNPPPVI FIRRDDEVVS ESSNM
Length:545
Mass (Da):60,161
Last modified:November 22, 2005 - v1
Checksum:iA1D267D18879D614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1.
RefSeqiXP_828335.1. XM_823242.1.

Genome annotation databases

GeneIDi3664265.
KEGGitbr:Tb11.02.0120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1.
RefSeqiXP_828335.1. XM_823242.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQHX-ray1.75A1-545[»]
ProteinModelPortaliQ386Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.Tb11.02.0120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3664265.
KEGGitbr:Tb11.02.0120.

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000186273.
InParanoidiQ386Q8.
KOiK00972.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  2. "A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei."
    Urbaniak M.D., Collie I.T., Fang W., Aristotelous T., Eskilsson S., Raimi O.G., Harrison J., Navratilova I.H., Frearson J.A., van Aalten D.M., Ferguson M.A.
    ACS Chem. Biol. 8:1981-1987(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), ACTIVE SITE.

Entry informationi

Entry nameiQ386Q8_TRYB2
AccessioniPrimary (citable) accession number: Q386Q8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.