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Q386Q8

- Q386Q8_TRYB2

UniProt

Q386Q8 - Q386Q8_TRYB2

Protein
Submitted name:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Gene

Tb11.02.0120

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei202 – 2021Sulfate 1Imported
    Binding sitei245 – 2451Sulfate 1Imported
    Binding sitei263 – 2631Sulfate 1Imported

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    NucleotidyltransferaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    UDP-N-acetylglucosamine pyrophosphorylase, putativeImported (EC:2.7.7.23Imported)
    Gene namesi
    ORF Names:Tb11.02.0120Imported
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
    Taxonomic identifieri999953 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    ProteomesiUP000008524: Chromosome 11 Scaffold 1

    Interactioni

    Protein-protein interaction databases

    STRINGi5691.Tb11.02.0120.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BQHX-ray1.75A1-545[»]
    ProteinModelPortaliQ386Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni510 – 5123Sulfate 2 bindingImported

    Phylogenomic databases

    eggNOGiCOG4284.
    HOGENOMiHOG000186273.
    KOiK00972.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q386Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRDVCIQR LTGANQDHIL TALEHGSEAE RASLTAQITN ELAGVDFRHF    50
    NDVLRESLEI SKNCSTASLA EPPAKDSFFD ISSVDRRRGQ AKRIKNLEAV 100
    GYKAIQKGQI AFLILAGGSG TRLGFDKPKG FFTCDGLQQR KSLFMMHCEK 150
    IRRRQEIAES ISGSGRKARV QLLVMTSGQN DAETQRFFEE NSYFGLEREQ 200
    VHFFAQSSVP CYDENTGRII MENRGRICAA PGGNGAVFAA LAAPRATKDK 250
    DGTLQVKESL LQHLRKLGIA YVQIGNIDNL LANVADPVFI GYAIEEEAHV 300
    VVKTCPKRGP DERVGVFVRA SGKWGVVEYT EIGDRAKEID DATGELKFNC 350
    ANISSNLCSL HFMSLAAERM KSFTQYHAAR KKIPTIKGPV MGIKLEAFLF 400
    DLFRFVDECD HPPKDSGAFR IMQVDRDDEF GPVKNADGAA SDTPADAVRL 450
    LLSQHTRWLI TALETAAMSD EQESIRGGVD VTEAKEAVAV MRSCSIKAEI 500
    SPLVSVGGEG LRQHLPRVIH QLLRNPPPVI FIRRDDEVVS ESSNM 545
    Length:545
    Mass (Da):60,161
    Last modified:November 22, 2005 - v1
    Checksum:iA1D267D18879D614
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH464491 Genomic DNA. Translation: EAN79223.1.
    RefSeqiXP_828335.1. XM_823242.1.

    Genome annotation databases

    EnsemblProtistsiEAN79223; EAN79223; Tb11.02.0120.
    GeneIDi3664265.
    KEGGitbr:Tb11.02.0120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH464491 Genomic DNA. Translation: EAN79223.1 .
    RefSeqi XP_828335.1. XM_823242.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BQH X-ray 1.75 A 1-545 [» ]
    ProteinModelPortali Q386Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5691.Tb11.02.0120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi EAN79223 ; EAN79223 ; Tb11.02.0120 .
    GeneIDi 3664265.
    KEGGi tbr:Tb11.02.0120.

    Phylogenomic databases

    eggNOGi COG4284.
    HOGENOMi HOG000186273.
    KOi K00972.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the African trypanosome Trypanosoma brucei."
      Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
      , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
      Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 927/4 GUTat10.1Imported.
    2. "A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei."
      Urbaniak M.D., Collie I.T., Fang W., Aristotelous T., Eskilsson S., Raimi O.G., Harrison J., Navratilova I.H., Frearson J.A., van Aalten D.M., Ferguson M.A.
      ACS Chem. Biol. 8:1981-1987(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).

    Entry informationi

    Entry nameiQ386Q8_TRYB2
    AccessioniPrimary (citable) accession number: Q386Q8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3