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Q386Q8 (Q386Q8_TRYB2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=2.7.7.23 EMBL EAN79223.1
Gene names
ORF Names:Tb11.02.0120 EMBL EAN79223.1
OrganismTrypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]
Taxonomic identifier999953 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region510 – 5123Sulfate 2 binding PDB 4BQH

Sites

Binding site2021Sulfate 1 PDB 4BQH
Binding site2451Sulfate 1 PDB 4BQH
Binding site2631Sulfate 1 PDB 4BQH

Sequences

Sequence LengthMass (Da)Tools
Q386Q8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: A1D267D18879D614

FASTA54560,161
        10         20         30         40         50         60 
MSDRDVCIQR LTGANQDHIL TALEHGSEAE RASLTAQITN ELAGVDFRHF NDVLRESLEI 

        70         80         90        100        110        120 
SKNCSTASLA EPPAKDSFFD ISSVDRRRGQ AKRIKNLEAV GYKAIQKGQI AFLILAGGSG 

       130        140        150        160        170        180 
TRLGFDKPKG FFTCDGLQQR KSLFMMHCEK IRRRQEIAES ISGSGRKARV QLLVMTSGQN 

       190        200        210        220        230        240 
DAETQRFFEE NSYFGLEREQ VHFFAQSSVP CYDENTGRII MENRGRICAA PGGNGAVFAA 

       250        260        270        280        290        300 
LAAPRATKDK DGTLQVKESL LQHLRKLGIA YVQIGNIDNL LANVADPVFI GYAIEEEAHV 

       310        320        330        340        350        360 
VVKTCPKRGP DERVGVFVRA SGKWGVVEYT EIGDRAKEID DATGELKFNC ANISSNLCSL 

       370        380        390        400        410        420 
HFMSLAAERM KSFTQYHAAR KKIPTIKGPV MGIKLEAFLF DLFRFVDECD HPPKDSGAFR 

       430        440        450        460        470        480 
IMQVDRDDEF GPVKNADGAA SDTPADAVRL LLSQHTRWLI TALETAAMSD EQESIRGGVD 

       490        500        510        520        530        540 
VTEAKEAVAV MRSCSIKAEI SPLVSVGGEG LRQHLPRVIH QLLRNPPPVI FIRRDDEVVS 


ESSNM 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the African trypanosome Trypanosoma brucei."
Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. expand/collapse author list , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 927/4 GUTat10.1 EMBL EAN79223.1.
[2]"A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei."
Urbaniak M.D., Collie I.T., Fang W., Aristotelous T., Eskilsson S., Raimi O.G., Harrison J., Navratilova I.H., Frearson J.A., van Aalten D.M., Ferguson M.A.
ACS Chem. Biol. 8:1981-1987(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH464491 Genomic DNA. Translation: EAN79223.1.
RefSeqXP_828335.1. XM_823242.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQHX-ray1.75A1-545[»]
ProteinModelPortalQ386Q8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5691.Tb11.02.0120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAN79223; EAN79223; Tb11.02.0120.
GeneID3664265.
KEGGtbr:Tb11.02.0120.

Phylogenomic databases

eggNOGCOG4284.
HOGENOMHOG000186273.
KOK00972.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans.
[Graphical view]
PANTHERPTHR11952. PTHR11952. 1 hit.
PfamPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ386Q8_TRYB2
AccessionPrimary (citable) accession number: Q386Q8
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)