SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q386Q8

- Q386Q8_TRYB2

UniProt

Q386Q8 - Q386Q8_TRYB2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: UDP-N-acetylglucosamine pyrophosphorylase, putative
Gene
Tb11.02.0120
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei202 – 2021Sulfate 1Imported
Binding sitei245 – 2451Sulfate 1Imported
Binding sitei263 – 2631Sulfate 1Imported

GO - Molecular functioni

  1. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
UDP-N-acetylglucosamine pyrophosphorylase, putativeImported (EC:2.7.7.23Imported)
Gene namesi
ORF Names:Tb11.02.0120Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
Taxonomic identifieri999953 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 11 Scaffold 1

Interactioni

Protein-protein interaction databases

STRINGi5691.Tb11.02.0120.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQHX-ray1.75A1-545[»]
ProteinModelPortaliQ386Q8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni510 – 5123Sulfate 2 bindingImported

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000186273.
KOiK00972.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q386Q8-1 [UniParc]FASTAAdd to Basket

« Hide

MSDRDVCIQR LTGANQDHIL TALEHGSEAE RASLTAQITN ELAGVDFRHF    50
NDVLRESLEI SKNCSTASLA EPPAKDSFFD ISSVDRRRGQ AKRIKNLEAV 100
GYKAIQKGQI AFLILAGGSG TRLGFDKPKG FFTCDGLQQR KSLFMMHCEK 150
IRRRQEIAES ISGSGRKARV QLLVMTSGQN DAETQRFFEE NSYFGLEREQ 200
VHFFAQSSVP CYDENTGRII MENRGRICAA PGGNGAVFAA LAAPRATKDK 250
DGTLQVKESL LQHLRKLGIA YVQIGNIDNL LANVADPVFI GYAIEEEAHV 300
VVKTCPKRGP DERVGVFVRA SGKWGVVEYT EIGDRAKEID DATGELKFNC 350
ANISSNLCSL HFMSLAAERM KSFTQYHAAR KKIPTIKGPV MGIKLEAFLF 400
DLFRFVDECD HPPKDSGAFR IMQVDRDDEF GPVKNADGAA SDTPADAVRL 450
LLSQHTRWLI TALETAAMSD EQESIRGGVD VTEAKEAVAV MRSCSIKAEI 500
SPLVSVGGEG LRQHLPRVIH QLLRNPPPVI FIRRDDEVVS ESSNM 545
Length:545
Mass (Da):60,161
Last modified:November 22, 2005 - v1
Checksum:iA1D267D18879D614
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1.
RefSeqiXP_828335.1. XM_823242.1.

Genome annotation databases

EnsemblProtistsiEAN79223; EAN79223; Tb11.02.0120.
GeneIDi3664265.
KEGGitbr:Tb11.02.0120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1 .
RefSeqi XP_828335.1. XM_823242.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BQH X-ray 1.75 A 1-545 [» ]
ProteinModelPortali Q386Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5691.Tb11.02.0120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAN79223 ; EAN79223 ; Tb11.02.0120 .
GeneIDi 3664265.
KEGGi tbr:Tb11.02.0120.

Phylogenomic databases

eggNOGi COG4284.
HOGENOMi HOG000186273.
KOi K00972.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  2. "A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei."
    Urbaniak M.D., Collie I.T., Fang W., Aristotelous T., Eskilsson S., Raimi O.G., Harrison J., Navratilova I.H., Frearson J.A., van Aalten D.M., Ferguson M.A.
    ACS Chem. Biol. 8:1981-1987(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).

Entry informationi

Entry nameiQ386Q8_TRYB2
AccessioniPrimary (citable) accession number: Q386Q8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi