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Q386Q8

- Q386Q8_TRYB2

UniProt

Q386Q8 - Q386Q8_TRYB2

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Protein
Submitted name:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Gene

Tb11.02.0120

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei202 – 2021Sulfate 1Imported
Binding sitei245 – 2451Sulfate 1Imported
Binding sitei263 – 2631Sulfate 1Imported

GO - Molecular functioni

  1. UDP-N-acetylglucosamine diphosphorylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
UDP-N-acetylglucosamine pyrophosphorylase, putativeImported (EC:2.7.7.23Imported)
Gene namesi
ORF Names:Tb11.02.0120Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 11 Scaffold 1

Interactioni

Protein-protein interaction databases

STRINGi5691.Tb11.02.0120.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQHX-ray1.75A1-545[»]
ProteinModelPortaliQ386Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni510 – 5123Sulfate 2 bindingImported

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000186273.
InParanoidiQ386Q8.
KOiK00972.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q386Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRDVCIQR LTGANQDHIL TALEHGSEAE RASLTAQITN ELAGVDFRHF
60 70 80 90 100
NDVLRESLEI SKNCSTASLA EPPAKDSFFD ISSVDRRRGQ AKRIKNLEAV
110 120 130 140 150
GYKAIQKGQI AFLILAGGSG TRLGFDKPKG FFTCDGLQQR KSLFMMHCEK
160 170 180 190 200
IRRRQEIAES ISGSGRKARV QLLVMTSGQN DAETQRFFEE NSYFGLEREQ
210 220 230 240 250
VHFFAQSSVP CYDENTGRII MENRGRICAA PGGNGAVFAA LAAPRATKDK
260 270 280 290 300
DGTLQVKESL LQHLRKLGIA YVQIGNIDNL LANVADPVFI GYAIEEEAHV
310 320 330 340 350
VVKTCPKRGP DERVGVFVRA SGKWGVVEYT EIGDRAKEID DATGELKFNC
360 370 380 390 400
ANISSNLCSL HFMSLAAERM KSFTQYHAAR KKIPTIKGPV MGIKLEAFLF
410 420 430 440 450
DLFRFVDECD HPPKDSGAFR IMQVDRDDEF GPVKNADGAA SDTPADAVRL
460 470 480 490 500
LLSQHTRWLI TALETAAMSD EQESIRGGVD VTEAKEAVAV MRSCSIKAEI
510 520 530 540
SPLVSVGGEG LRQHLPRVIH QLLRNPPPVI FIRRDDEVVS ESSNM
Length:545
Mass (Da):60,161
Last modified:November 22, 2005 - v1
Checksum:iA1D267D18879D614
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1.
RefSeqiXP_828335.1. XM_823242.1.

Genome annotation databases

GeneIDi3664265.
KEGGitbr:Tb11.02.0120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH464491 Genomic DNA. Translation: EAN79223.1 .
RefSeqi XP_828335.1. XM_823242.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BQH X-ray 1.75 A 1-545 [» ]
ProteinModelPortali Q386Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5691.Tb11.02.0120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3664265.
KEGGi tbr:Tb11.02.0120.

Phylogenomic databases

eggNOGi COG4284.
HOGENOMi HOG000186273.
InParanoidi Q386Q8.
KOi K00972.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  2. "A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei."
    Urbaniak M.D., Collie I.T., Fang W., Aristotelous T., Eskilsson S., Raimi O.G., Harrison J., Navratilova I.H., Frearson J.A., van Aalten D.M., Ferguson M.A.
    ACS Chem. Biol. 8:1981-1987(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).

Entry informationi

Entry nameiQ386Q8_TRYB2
AccessioniPrimary (citable) accession number: Q386Q8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3