ID   Q386F2_TRYB2            Unreviewed;       273 AA.
AC   Q386F2;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=40S ribosomal protein S4 {ECO:0000256|PIRNR:PIRNR002116};
GN   ORFNames=Tb11.02.1085 {ECO:0000313|EMBL:EAN79328.1}, Tb11.02.1090
GN   {ECO:0000313|EMBL:EAN79329.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN79329.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79329.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:EAN79329.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79329.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [3] {ECO:0007829|PDB:4V8M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX   PubMed=23395961; DOI=10.1038/nature11872;
RA   Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA   Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA   Madison-Antenucci S., Frank J.;
RT   "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT   brucei ribosome.";
RL   Nature 494:385-389(2013).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC       {ECO:0000256|ARBA:ARBA00007500, ECO:0000256|PIRNR:PIRNR002116}.
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DR   EMBL; CH464491; EAN79328.1; -; Genomic_DNA.
DR   EMBL; CH464491; EAN79329.1; -; Genomic_DNA.
DR   RefSeq; XP_828440.1; XM_823347.1.
DR   RefSeq; XP_828441.1; XM_823348.1.
DR   PDB; 4V8M; EM; 5.57 A; A1=1-273.
DR   PDBsum; 4V8M; -.
DR   AlphaFoldDB; Q386F2; -.
DR   EMDB; EMD-17208; -.
DR   EMDB; EMD-17212; -.
DR   IntAct; Q386F2; 1.
DR   STRING; 185431.Q386F2; -.
DR   PaxDb; 5691-EAN79328; -.
DR   GeneID; 3664994; -.
DR   GeneID; 3664995; -.
DR   KEGG; tbr:Tb11.02.1085; -.
DR   KEGG; tbr:Tb11.02.1090; -.
DR   VEuPathDB; TriTrypDB:Tb11.v5.1059; -.
DR   VEuPathDB; TriTrypDB:Tb927.11.3590; -.
DR   VEuPathDB; TriTrypDB:Tb927.11.3600; -.
DR   eggNOG; KOG0378; Eukaryota.
DR   InParanoid; Q386F2; -.
DR   OrthoDB; 5471107at2759; -.
DR   Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005840; C:ribosome; ISM:GeneDB.
DR   GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR   GO; GO:0003723; F:RNA binding; ISM:GeneDB.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR   GO; GO:0006412; P:translation; ISM:GeneDB.
DR   CDD; cd06087; KOW_RPS4; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.740; -; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   HAMAP; MF_00485; Ribosomal_S4e; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR000876; Ribosomal_eS4.
DR   InterPro; IPR032277; Ribosomal_eS4_C.
DR   InterPro; IPR013845; Ribosomal_eS4_central_region.
DR   InterPro; IPR038237; Ribosomal_eS4_central_sf.
DR   InterPro; IPR041982; Ribosomal_eS4_KOW.
DR   InterPro; IPR013843; Ribosomal_eS4_N.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11581; 30S/40S RIBOSOMAL PROTEIN S4; 1.
DR   PANTHER; PTHR11581:SF0; 40S RIBOSOMAL PROTEIN S4; 1.
DR   Pfam; PF16121; 40S_S4_C; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   Pfam; PF01479; S4; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00363; S4; 1.
DR   PROSITE; PS50889; S4; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4V8M};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|PIRNR:PIRNR002116};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW   ECO:0000256|PIRNR:PIRNR002116};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR002116};
KW   rRNA-binding {ECO:0000256|ARBA:ARBA00022730,
KW   ECO:0000256|PIRNR:PIRNR002116}.
FT   DOMAIN          40..103
FT                   /note="RNA-binding S4"
FT                   /evidence="ECO:0000259|SMART:SM00363"
FT   DOMAIN          171..198
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
SQ   SEQUENCE   273 AA;  30644 MW;  CAAA858CC7C17982 CRC64;
     MAKKHLKRLY APKDWMLSKL TGVFAPRPRA GPHKLRECLS LLIIIRNRLK YALNALEAQM
     ILRQGLVCVD GKPRKDGKYP AGFMDVVEIP KTGDRFRILY DVKGRFALVR VSEAESSIKM
     MKVVNVYTGT GRIPVAVTHD GHRIRYPDPR TSRGDTLVYD VKEKKVLDLI KIGNGKVVMV
     TGGANRGRIG EIVSIERHPG AFDIARLKDA SGHEFATRAT NIFVIGKDMS SVPVTLPKQQ
     GLRINVIQER EEKLIAAETR RTTQAHSKRK TKV
//