Q38653 (ALYS_BPA51) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endolysin
EC=3.5.1.28

Alternative name(s):
N-acetylmuramoyl-L-alanine amidase

Gene names

Name:

PLY511

Organism

Listeria phage A511 (Bacteriophage A511)

Taxonomic identifier

40523 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Spounavirinae › Twortlikevirus

Virus host

Listeria monocytogenes [TaxID: 1639]

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Subcellular location	Secreted Potential.
Developmental stage	Expressed at about 20 minutes after infection.
Sequence similarities	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Secreted
Domain	Repeat
Molecular function	Antimicrobial Bacteriolytic enzyme Hydrolase
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Endolysin		PRO_0000164405

Sequences

	Sequence		Length	Mass (Da)
	Q38653 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 86C40B73F0FD8547	FASTA	341	36,477
	10 20 30 40 50 60 MVKYTVENKI IAGLPKGKLK GANFVIAHET ANSKSTIDNE VSYMTRNWKN AFVTHFVGGG 70 80 90 100 110 120 GRVVQVANVN YVSWGAGQYA NSYSYAQVEL CRTSNATTFK KDYEVYCQLL VDLAKKAGIP 130 140 150 160 170 180 ITLDSGSKTS DKGIKSHKWV ADKLGGTTHQ DPYAYLSSWG ISKAQFASDL AKVSGGGNTG 190 200 210 220 230 240 TAPAKPSTPA PKPSTPSTNL DKLGLVDYMN AKKMDSSYSN RDKLAKQYGI ANYSGTASQN 250 260 270 280 290 300 TTLLSKIKGG APKPSTPAPK PSTSTAKKIY FPPNKGNWSV YPTNKAPVKA NAIGAINPTK 310 320 330 340 FGGLTYTIQK DRGNGVYEIQ TDQFGRVQVY GAPSTGAVIK K

References

[1]

"Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes." Loessner M.J., Wendlinger G., Scherer S. Mol. Microbiol. 16:1231-1241(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85010 Genomic DNA. Translation: CAA59368.1.
PIR	S69802.
RefSeq	YP_001468459.1. NC_009811.2.
3D structure databases
ProteinModelPortal	Q38653.
ModBase	Search...
Protein family/group databases
MEROPS	M15.950.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5601499.
Phylogenomic databases
ProtClustDB	CLSP2743618.
Family and domain databases
Gene3D	3.40.80.10. 1 hit.
InterPro	IPR002502. Amidase_domain. [Graphical view]
Pfam	PF01510. Amidase_2. 1 hit. [Graphical view]
SMART	SM00644. Ami_2. 1 hit. [Graphical view]
SUPFAM	SSF55846. Amidase_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALYS_BPA51

Accession

Primary (citable) accession number: Q38653

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program