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Protein

Endolysin

Gene

PLY511

Organism
Listeria phage A511 (Bacteriophage A511)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

MEROPSiM15.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Endolysin (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:PLY511
OrganismiListeria phage A511 (Bacteriophage A511)
Taxonomic identifieri40523 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeSpounavirinaeTwortlikevirus
Virus hostiListeria monocytogenes [TaxID: 1639]

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341EndolysinPRO_0000164405Add
BLAST

Expressioni

Developmental stagei

Expressed at about 20 minutes after infection.

Structurei

3D structure databases

ProteinModelPortaliQ38653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKYTVENKI IAGLPKGKLK GANFVIAHET ANSKSTIDNE VSYMTRNWKN
60 70 80 90 100
AFVTHFVGGG GRVVQVANVN YVSWGAGQYA NSYSYAQVEL CRTSNATTFK
110 120 130 140 150
KDYEVYCQLL VDLAKKAGIP ITLDSGSKTS DKGIKSHKWV ADKLGGTTHQ
160 170 180 190 200
DPYAYLSSWG ISKAQFASDL AKVSGGGNTG TAPAKPSTPA PKPSTPSTNL
210 220 230 240 250
DKLGLVDYMN AKKMDSSYSN RDKLAKQYGI ANYSGTASQN TTLLSKIKGG
260 270 280 290 300
APKPSTPAPK PSTSTAKKIY FPPNKGNWSV YPTNKAPVKA NAIGAINPTK
310 320 330 340
FGGLTYTIQK DRGNGVYEIQ TDQFGRVQVY GAPSTGAVIK K
Length:341
Mass (Da):36,477
Last modified:November 1, 1996 - v1
Checksum:i86C40B73F0FD8547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85010 Genomic DNA. Translation: CAA59368.1.
PIRiS69802.
RefSeqiYP_001468459.1. NC_009811.2.

Genome annotation databases

GeneIDi5601499.
KEGGivg:5601499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85010 Genomic DNA. Translation: CAA59368.1.
PIRiS69802.
RefSeqiYP_001468459.1. NC_009811.2.

3D structure databases

ProteinModelPortaliQ38653.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM15.950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5601499.
KEGGivg:5601499.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes."
    Loessner M.J., Wendlinger G., Scherer S.
    Mol. Microbiol. 16:1231-1241(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALYS_BPA51
AccessioniPrimary (citable) accession number: Q38653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.