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Q38653

- ALYS_BPA51

UniProt

Q38653 - ALYS_BPA51

Protein

Endolysin

Gene

PLY511

Organism
Listeria phage A511 (Bacteriophage A511)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to bacterium Source: UniProtKB-KW
    3. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Protein family/group databases

    MEROPSiM15.950.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endolysin (EC:3.5.1.28)
    Alternative name(s):
    N-acetylmuramoyl-L-alanine amidase
    Gene namesi
    Name:PLY511
    OrganismiListeria phage A511 (Bacteriophage A511)
    Taxonomic identifieri40523 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeSpounavirinaeTwortlikevirus
    Virus hostiListeria monocytogenes [TaxID: 1639]

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341EndolysinPRO_0000164405Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed at about 20 minutes after infection.

    Structurei

    3D structure databases

    ProteinModelPortaliQ38653.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    [Graphical view]
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    SMARTiSM00644. Ami_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q38653-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKYTVENKI IAGLPKGKLK GANFVIAHET ANSKSTIDNE VSYMTRNWKN    50
    AFVTHFVGGG GRVVQVANVN YVSWGAGQYA NSYSYAQVEL CRTSNATTFK 100
    KDYEVYCQLL VDLAKKAGIP ITLDSGSKTS DKGIKSHKWV ADKLGGTTHQ 150
    DPYAYLSSWG ISKAQFASDL AKVSGGGNTG TAPAKPSTPA PKPSTPSTNL 200
    DKLGLVDYMN AKKMDSSYSN RDKLAKQYGI ANYSGTASQN TTLLSKIKGG 250
    APKPSTPAPK PSTSTAKKIY FPPNKGNWSV YPTNKAPVKA NAIGAINPTK 300
    FGGLTYTIQK DRGNGVYEIQ TDQFGRVQVY GAPSTGAVIK K 341
    Length:341
    Mass (Da):36,477
    Last modified:November 1, 1996 - v1
    Checksum:i86C40B73F0FD8547
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85010 Genomic DNA. Translation: CAA59368.1.
    PIRiS69802.
    RefSeqiYP_001468459.1. NC_009811.2.

    Genome annotation databases

    GeneIDi5601499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85010 Genomic DNA. Translation: CAA59368.1 .
    PIRi S69802.
    RefSeqi YP_001468459.1. NC_009811.2.

    3D structure databases

    ProteinModelPortali Q38653.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M15.950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5601499.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    [Graphical view ]
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes."
      Loessner M.J., Wendlinger G., Scherer S.
      Mol. Microbiol. 16:1231-1241(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiALYS_BPA51
    AccessioniPrimary (citable) accession number: Q38653
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3