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Q38653 (ALYS_BPA51) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endolysin

EC=3.5.1.28
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene names
Name:PLY511
OrganismListeria phage A511 (Bacteriophage A511)
Taxonomic identifier40523 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeSpounavirinaeTwortlikevirus
Virus hostListeria monocytogenes [TaxID: 1639]

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted Potential.

Developmental stage

Expressed at about 20 minutes after infection.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
   Biological processCell wall biogenesis/degradation
   Cellular componentSecreted
   DomainRepeat
   Molecular functionAntimicrobial
Bacteriolytic enzyme
Hydrolase
Gene Ontology (GO)
   Biological_processcytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

defense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

peptidoglycan catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetylmuramoyl-L-alanine amidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Endolysin
PRO_0000164405

Sequences

Sequence LengthMass (Da)Tools
Q38653 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 86C40B73F0FD8547

FASTA34136,477
        10         20         30         40         50         60 
MVKYTVENKI IAGLPKGKLK GANFVIAHET ANSKSTIDNE VSYMTRNWKN AFVTHFVGGG 

        70         80         90        100        110        120 
GRVVQVANVN YVSWGAGQYA NSYSYAQVEL CRTSNATTFK KDYEVYCQLL VDLAKKAGIP 

       130        140        150        160        170        180 
ITLDSGSKTS DKGIKSHKWV ADKLGGTTHQ DPYAYLSSWG ISKAQFASDL AKVSGGGNTG 

       190        200        210        220        230        240 
TAPAKPSTPA PKPSTPSTNL DKLGLVDYMN AKKMDSSYSN RDKLAKQYGI ANYSGTASQN 

       250        260        270        280        290        300 
TTLLSKIKGG APKPSTPAPK PSTSTAKKIY FPPNKGNWSV YPTNKAPVKA NAIGAINPTK 

       310        320        330        340 
FGGLTYTIQK DRGNGVYEIQ TDQFGRVQVY GAPSTGAVIK K 

« Hide

References

[1]"Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes."
Loessner M.J., Wendlinger G., Scherer S.
Mol. Microbiol. 16:1231-1241(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X85010 Genomic DNA. Translation: CAA59368.1.
PIRS69802.
RefSeqYP_001468459.1. NC_009811.2.

3D structure databases

ProteinModelPortalQ38653.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM15.950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5601499.

Phylogenomic databases

ProtClustDBCLSP2743618.

Family and domain databases

Gene3D3.40.80.10. 1 hit.
InterProIPR002502. Amidase_domain.
[Graphical view]
PfamPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMSSF55846. SSF55846. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALYS_BPA51
AccessionPrimary (citable) accession number: Q38653
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families