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Q385E8 (Q385E8_TRYB2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=1.14.13.70 EMBL EAN79583.1
Gene names
ORF Names:Tb11.02.4080 EMBL EAN79583.1
OrganismTrypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]
Taxonomic identifier999953 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding4221Iron (heme axial ligand) PDB 3TIK PDB 2WV2 PDB 2X2N PDB 3P99 PDB 3G1Q PDB 3GW9 PDB 4BJK PDB 4G3J PDB 4G7G

Sequences

Sequence LengthMass (Da)Tools
Q385E8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 10579D3A25BDF6F4

FASTA48154,372
        10         20         30         40         50         60 
MLLEVAIFLL TALALYSFYF VKSFNVTRPT DPPVYPVTVP ILGHIIQFGK SPLGFMQECK 

        70         80         90        100        110        120 
RQLKSGIFTI NIVGKRVTIV GDPHEHSRFF LPRNEVLSPR EVYSFMVPVF GEGVAYAAPY 

       130        140        150        160        170        180 
PRMREQLNFL AEELTIAKFQ NFVPAIQHEV RKFMAANWDK DEGEINLLED CSTMIINTAC 

       190        200        210        220        230        240 
QCLFGEDLRK RLDARRFAQL LAKMESSLIP AAVFLPILLK LPLPQSARCH EARTELQKIL 

       250        260        270        280        290        300 
SEIIIARKEE EVNKDSSTSD LLSGLLSAVY RDGTPMSLHE VCGMIVAAMF AGQHTSSITT 

       310        320        330        340        350        360 
TWSMLHLMHP ANVKHLEALR KEIEEFPAQL NYNNVMDEMP FAERCARESI RRDPPLLMLM 

       370        380        390        400        410        420 
RKVMADVKVG SYVVPKGDII ACSPLLSHHD EEAFPEPRRW DPERDEKVEG AFIGFGAGVH 

       430        440        450        460        470        480 
KCIGQKFGLL QVKTILATAF RSYDFQLLRD EVPDPDYHTM VVGPTASQCR VKYIRRKAAA 


A 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the African trypanosome Trypanosoma brucei."
Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. expand/collapse author list , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 927/4 GUTat10.1 EMBL EAN79583.1.
[2]"Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections."
Lepesheva G.I., Park H.W., Hargrove T.Y., Vanhollebeke B., Wawrzak Z., Harp J.M., Sundaramoorthy M., Nes W.D., Pays E., Chaudhuri M., Villalta F., Waterman M.R.
J. Biol. Chem. 285:1773-1780(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 29-477 IN COMPLEX WITH HEME.
[3]"Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole."
Chen C.K., Leung S.S., Guilbert C., Jacobson M.P., McKerrow J.H., Podust L.M.
PLoS Negl. Trop. Dis. 4:e651-e651(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 22-481 IN COMPLEX WITH HEME.
[4]"Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib."
Buckner F.S., Bahia M.T., Suryadevara P.K., White K.L., Shackleford D.M., Chennamaneni N.K., Hulverson M.A., Laydbak J.U., Chatelain E., Scandale I., Verlinde C.L., Charman S.A., Lepesheva G.I., Gelb M.H.
Antimicrob. Agents Chemother. 56:4914-4921(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 32-481 IN COMPLEX WITH HEME.
[5]"Structural complex of sterol 14?-demethylase (CYP51) with 14?-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol."
Hargrove T.Y., Wawrzak Z., Liu J., Waterman M.R., Nes W.D., Lepesheva G.I.
J. Lipid Res. 53:311-320(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 29-481 IN COMPLEX WITH HEME.
[6]"CYP51 structure-based VNI scaffold development."
Hargrove T.Y., Wawrzak Z., Waterman M.R., Lepesheva G.I.
Submitted (JUL-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 29-476 IN COMPLEX WITH HEME.
[7]"Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents."
Choi J.Y., Calvet C.M., Gunatilleke S.S., Ruiz C., Cameron M.D., McKerrow J.H., Podust L.M., Roush W.R.
J. Med. Chem. 56:7651-7668(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.67 ANGSTROMS) OF 32-481 IN COMPLEX WITH HEME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH464491 Genomic DNA. Translation: EAN79583.1.
RefSeqXP_828695.1. XM_823602.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WV2X-ray2.70A22-481[»]
2X2NX-ray2.60A/B/C/D22-481[»]
3G1QX-ray1.89A/B/C/D29-476[»]
3GW9X-ray1.87A/B/C/D29-477[»]
3P99X-ray3.00A/B/C/D29-481[»]
3TIKX-ray2.05A/B/C/D32-481[»]
4BJKX-ray2.67A/B/C/D32-481[»]
4G3JX-ray1.83A/B/C/D29-476[»]
4G7GX-ray2.05A/B/C/D29-476[»]
ProteinModelPortalQ385E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5691.Tb11.02.4080.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAN79583; EAN79583; Tb11.02.4080.
GeneID3665105.
KEGGtbr:Tb11.02.4080.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000042780.
KOK05917.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00465. EP450IV.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ385E8.

Entry information

Entry nameQ385E8_TRYB2
AccessionPrimary (citable) accession number: Q385E8
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)