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Protein
Submitted name:

Lanosterol 14-alpha-demethylase

Gene

Tb11.02.4080

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi422Iron (heme axial ligand)Combined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, MonooxygenaseUniRule annotation, Oxidoreductase, Transferase

Keywords - Ligandi

HemeUniRule annotationCombined sources, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Lanosterol 14-alpha-demethylaseImported (EC:1.14.13.70Imported)
Gene namesi
ORF Names:Tb11.02.4080Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000008524 Componenti: Chromosome 11 Scaffold 1

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.11.6210.

Interactioni

Chemistry databases

BindingDBiQ385E8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WV2X-ray2.70A22-481[»]
2X2NX-ray2.60A/B/C/D22-481[»]
3G1QX-ray1.89A/B/C/D29-476[»]
3GW9X-ray1.87A/B/C/D29-477[»]
3P99X-ray3.00A/B/C/D29-481[»]
3TIKX-ray2.05A/B/C/D32-481[»]
4BJKX-ray2.67A/B/C/D32-481[»]
4G3JX-ray1.83A/B/C/D29-476[»]
4G7GX-ray2.05A/B/C/D29-476[»]
ProteinModelPortaliQ385E8.
SMRiQ385E8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ385E8.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000042780.
InParanoidiQ385E8.
KOiK05917.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q385E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEVAIFLL TALALYSFYF VKSFNVTRPT DPPVYPVTVP ILGHIIQFGK
60 70 80 90 100
SPLGFMQECK RQLKSGIFTI NIVGKRVTIV GDPHEHSRFF LPRNEVLSPR
110 120 130 140 150
EVYSFMVPVF GEGVAYAAPY PRMREQLNFL AEELTIAKFQ NFVPAIQHEV
160 170 180 190 200
RKFMAANWDK DEGEINLLED CSTMIINTAC QCLFGEDLRK RLDARRFAQL
210 220 230 240 250
LAKMESSLIP AAVFLPILLK LPLPQSARCH EARTELQKIL SEIIIARKEE
260 270 280 290 300
EVNKDSSTSD LLSGLLSAVY RDGTPMSLHE VCGMIVAAMF AGQHTSSITT
310 320 330 340 350
TWSMLHLMHP ANVKHLEALR KEIEEFPAQL NYNNVMDEMP FAERCARESI
360 370 380 390 400
RRDPPLLMLM RKVMADVKVG SYVVPKGDII ACSPLLSHHD EEAFPEPRRW
410 420 430 440 450
DPERDEKVEG AFIGFGAGVH KCIGQKFGLL QVKTILATAF RSYDFQLLRD
460 470 480
EVPDPDYHTM VVGPTASQCR VKYIRRKAAA A
Length:481
Mass (Da):54,372
Last modified:November 22, 2005 - v1
Checksum:i10579D3A25BDF6F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA. Translation: EAN79583.1.
RefSeqiXP_828695.1. XM_823602.1.

Genome annotation databases

EnsemblProtistsiEAN79583; EAN79583; Tb11.02.4080.
GeneDBiTb927.11.6210:pep.
GeneIDi3665105.
KEGGitbr:Tb11.02.4080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA. Translation: EAN79583.1.
RefSeqiXP_828695.1. XM_823602.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WV2X-ray2.70A22-481[»]
2X2NX-ray2.60A/B/C/D22-481[»]
3G1QX-ray1.89A/B/C/D29-476[»]
3GW9X-ray1.87A/B/C/D29-477[»]
3P99X-ray3.00A/B/C/D29-481[»]
3TIKX-ray2.05A/B/C/D32-481[»]
4BJKX-ray2.67A/B/C/D32-481[»]
4G3JX-ray1.83A/B/C/D29-476[»]
4G7GX-ray2.05A/B/C/D29-476[»]
ProteinModelPortaliQ385E8.
SMRiQ385E8.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ385E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAN79583; EAN79583; Tb11.02.4080.
GeneDBiTb927.11.6210:pep.
GeneIDi3665105.
KEGGitbr:Tb11.02.4080.

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.11.6210.

Phylogenomic databases

HOGENOMiHOG000042780.
InParanoidiQ385E8.
KOiK05917.

Miscellaneous databases

EvolutionaryTraceiQ385E8.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ385E8_TRYB2
AccessioniPrimary (citable) accession number: Q385E8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.